Orthohepadnavirus | |
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TEM micrograph showing Hepatitis B virus virions | |
Virus classification | |
(unranked): | Virus |
Realm: | Riboviria |
Kingdom: | Pararnavirae |
Phylum: | Artverviricota |
Class: | Revtraviricetes |
Order: | Blubervirales |
Family: | Hepadnaviridae |
Genus: | Orthohepadnavirus |
Species | |
See text |
Orthohepadnavirus is a genus of viruses, in the family Hepadnaviridae . [1] Humans and other mammals serve as natural hosts. There are 12 species in this genus. [1] Diseases associated with this genus include: hepatitis, hepatocellular carcinoma (chronic infections), and cirrhosis. [1] [2]
The genus contains the following species: [3]
Viruses in the genus Orthohepadnavirus are enveloped, with spherical geometries, and T=4 symmetry. The diameter is around 42 nm. Genomes are circular, around 3.2kb in length. The genome codes for 7 proteins. [1] [2]
Genus | Structure | Symmetry | Capsid | Genomic arrangement | Genomic segmentation |
---|---|---|---|---|---|
Orthohepadnavirus | Icosahedral | T=4 | Non-enveloped | Circular | Monopartite |
Viral replication is nucleo-cytoplasmic. Replication follows the dsDNA(RT) replication model. DNA-templated transcription, specifically dsDNA(RT) transcription, with some alternative splicing mechanism is the method of transcription. Translation takes place by leaky scanning. The virus exits the host cell by budding, and nuclear pore export. Human and mammals serve as the natural host. Transmission routes are sexual, blood, and contact. [1] [2]
Genus | Host details | Tissue tropism | Entry details | Release details | Replication site | Assembly site | Transmission |
---|---|---|---|---|---|---|---|
Orthohepadnavirus | Humans; mammals | Hepatocytes | Cell receptor endocytosis | Budding | Nucleus | Cytoplasm | Vertical: parental; sex; blood |
Hepadnaviridae is a family of viruses. Humans, apes, and birds serve as natural hosts. There are currently 18 species in this family, divided among 5 genera. Its best-known member is hepatitis B virus. Diseases associated with this family include: liver infections, such as hepatitis, hepatocellular carcinomas, and cirrhosis. It is the sole accepted family in the order Blubervirales.
Rhadinovirus is a genus of viruses in the order Herpesvirales, in the family Herpesviridae, in the subfamily Gammaherpesvirinae. Humans and other mammals serve as natural hosts. There are 12 species in this genus. Diseases associated with this genus include: Kaposi's sarcoma, primary effusion lymphoma and multicentric Castleman's disease, caused by Human gammaherpesvirus 8 (HHV-8), also known as Kaposi's sarcoma-associated herpesvirus (KSHV). The term rhadino comes from the Latin fragile, referring to the tendency of the viral genome to break apart when it is isolated.
Alphaherpesvirinae is a subfamily of viruses in the family Herpesviridae, primarily distinguished by reproducing more quickly than other subfamilies in the Herpesviridae. In animal virology the most important herpesviruses belong to the Alphaherpesvirinae. Pseudorabies virus is the causative agent of Aujeszky's disease in pigs and Bovine herpesvirus 1 is the causative agent of bovine infectious rhinotracheitis and pustular vulvovaginitis. Mammals serve as natural hosts. There are currently 45 species in this subfamily, divided among 5 genera with one species unassigned to a genus. Diseases associated with this subfamily include: HHV-1 and HHV-2: skin vesicles or mucosal ulcers, rarely encephalitis and meningitis, HHV-3: chickenpox (varicella) and shingles, GaHV-2: Marek's disease.
Baltimore classification is a system used to classify viruses based on their manner of messenger RNA (mRNA) synthesis. By organizing viruses based on their manner of mRNA production, it is possible to study viruses that behave similarly as a distinct group. Seven Baltimore groups are described that take into consideration whether the viral genome is made of deoxyribonucleic acid (DNA) or ribonucleic acid (RNA), whether the genome is single- or double-stranded, and whether the sense of a single-stranded RNA genome is positive or negative.
Avihepadnavirus is a genus of viruses, in the family Hepadnaviridae. Birds serve as natural hosts. There are three species in this genus. Diseases associated with this genus include: hepatitis, hepatocellular carcinomas, and cirrhosis.
Petuvirus is a genus of viruses, in the family Caulimoviridae order Ortervirales. Plants serve as natural hosts. There is only one species in this genus: Petunia vein clearing virus. Diseases associated with this genus include: plants: chlorotic vein clearing, leaf malformation.
Lymphocryptovirus is a genus of viruses in the order Herpesvirales, in the family Herpesviridae, in the subfamily Gammaherpesvirinae. This genus includes the human-infecting Human gammaherpesvirus 4, as well as viruses that infect both Old World monkeys and New World monkeys. Other names for the Lymphocryptovirus genus include Lymphocryptoviridae and gamma-1 herpesviruses. There are nine species in this genus. Diseases associated with this genus include: mononucleosis, Burkitt's lymphoma, and nasopharyngeal carcinoma.
Simplexvirus is a genus of viruses in the order Herpesvirales, in the family Herpesviridae, in the subfamily Alphaherpesvirinae. Humans and mammals serve as natural hosts. Diseases associated with this genus include skin vesicles or mucosal ulcers, rarely encephalitis, and meningitis.
Mastadenovirus is a genus of viruses in the family Adenoviridae. Humans and other mammals serve as natural hosts. There are 51 species in this genus. The genus as a whole includes many very common causes of human infection, estimated to be responsible for 2 to 5% of all respiratory infections, as well as gastrointestinal and eye infections. Symptoms are usually mild.
Alphapapillomavirus is a genus of viruses, in the family Papillomaviridae. Human and monkeys serve as natural hosts. There are 14 species in this genus. Diseases associated with this genus include: warts, papilloma, malignant tumours. Genital-type, high-risk of malignancy : HPV-16, 18. Genital-type, low-risk of malignancy : HPV-6, 11.
Betapapillomavirus is a genus of viruses, in the family Papillomaviridae. Human serve as natural hosts. There are six species in this genus. Diseases associated with this genus include warts, papilloma, and malignant tumours.
Caulimovirus is a genus of viruses, in the family Caulimoviridae order Ortervirales. Plants serve as natural hosts. There are 12 species in this genus. Diseases associated with this genus include: vein-clearing or banding mosaic.
Cavemovirus is a genus of viruses, in the family Caulimoviridae order Ortervirales. Plants serve as natural hosts. There are three species in this genus. Diseases associated with this genus include: vein-clearing or banding mosaic.
Gammapapillomavirus is a genus of viruses, in the family Papillomaviridae. Human serve as natural hosts. There are 27 species in this genus. Diseases associated with this genus include: warts, papilloma.
Macavirus is a genus of viruses in the order Herpesvirales, in the family Herpesviridae, in the subfamily Gammaherpesvirinae. Mammals serve as natural hosts. There are nine species in this genus. Diseases associated with this genus include: inapparent infection in their reservoir hosts, but fatal lymphoproliferative disease when they infect MCF-susceptible hosts, including cattle, deer, bison, water buffalo and pigs.
Mupapillomavirus is a genus of viruses in the family Papillomaviridae. Humans serve as natural hosts. There are three species in this genus. Diseases associated with this genus include palmoplantar warts.
Nupapillomavirus is a genus of viruses, in the family Papillomaviridae. Humans serve as natural hosts. There is only one species in this genus: Nupapillomavirus 1. Diseases associated with this genus include: facial warts. It has also been detected in some skin carcinomas and premalignant keratoses.
Percavirus is a genus of viruses in the order Herpesvirales, in the family Herpesviridae, in the subfamily Gammaherpesvirinae. Mammals serve as natural hosts. There are six species in this genus. Diseases associated with this genus include: conjunctivitis, immunosuppression in foals, pneumonia, respiratory disease.
Soymovirus is a genus of viruses, in the family Caulimoviridae order Ortervirales. Plants serve as natural hosts. There are four species in this genus.
Solendovirus is a genus of viruses, in the family Caulimoviridae order Ortervirales. Plants serve as natural hosts. There are two species in this genus. Diseases associated with this genus include: TVCV: vein-clearing symptoms in N. edwardsonii.