Semotivirus

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Semotivirus
Virus classification OOjs UI icon edit-ltr.svg
(unranked): Virus
Realm: Riboviria
Kingdom: Pararnavirae
Phylum: Artverviricota
Class: Revtraviricetes
Order: Ortervirales
Family: Belpaoviridae
Genus:Semotivirus
Species

See text

Semotivirus is the only genus of viruses in the family Belpaoviridae (formerly included in the family Metaviridae ). [1] Species exist as retrotransposons in a eukaryotic host's genome. BEL/pao transposons are only found in animals. Semotivirus is the only genus currently recognized, the genus description corresponds to the family, Belpaoviridae description. [2]

Contents

Classification

The lone genus in the family, Semotivirus, was formerly included in the Metaviridae family but was removed due to its paraphyletic relationship to other Metaviridae genera. There is a good chance that more species and genera will be added to the family Belpaoviridae in the future, given the diversity of belpaovirids that is already recognized. The Pol domain order of the families Belpaoviridae, Metaviridae, and Retroviridae is the same within the order Ortervirales , however the integrase is either lacking in the case of the Caulimoviridae or positioned upstream of the protease domain in the case of the Pseudoviridae . [3]

The genus is made up of long terminal repeat (LTR) retrotransposons, also referred to as metazoan-infecting reverse transcriptase viruses. [4]

Composition

The genomic arrangement of members of the Belpaoviridae family is similar to that of long terminal repeat (LTR) retrotransposons of the Metaviridae family. [5] The entire genome is 4.2–10 kb, and one to three genes (pol, env, and gag) are flanked by LTRs of 0.2–1.2 kb. [6] A non-coding region that represents the initial segment of the reverse-transcribed genome is located downstream of the 5′-LTR. This is followed by an 18 nt primer-binding site that is complementary to a certain area inside the 3′-end of a host tRNAArg or a tRNAGly.

Priming the synthesis of the proviral DNA strand is a polypurine tract of approximately 10 nt located upstream of the 3′-LTR. Gag and Pol polyproteins can be encoded by one continuous gene or by two overlapping genes. [7] These genes encode the capsid and nucleocapsid domains, as well as the protease, reverse transcriptase (RT), ribonuclease H, and integrase domains.

Replication

Few information is known about the virion morphology of belpaovirids. The virion morphology of semotivirus is poorly understood. However, belpaovirids most likely replicate by forming virus-like particles (VLPs), just like retrovirids, metavirids, and pseudovirids do, since they encode a Gag polyprotein with nucleocapsid and capsid protein domains homologous to those of other members of the order Ortervirales. [8] [9] An env-like gene is present in certain belpaovirids, however its exact role is still unknown. [10]

Although the details of replication are not well known, it is thought to resemble that of members of the Metaviridae family, [11] in which RT mediates the conversion of a full transcript into a dsDNA that is incorporated into the host genome by the integrase protein. After the integrated provirus has been transcribed by the host RNA polymerase II, new virus RNAs are created, which the matching host enzymes cap and polyadenylate. Once in the host cell's cytoplasm, these fresh viral RNAs are translated into immature VLPs by Gag and Pol. VLP maturation is the end outcome of the viral protease's proteolytic processing of the polyproteins. The new viral RNAs are then reverse-transcribed by RT into dsDNA molecules, which are then sent back to the nucleus and inserted into fresh locations within the host cell genome. [12]

RT: Reverse Transcripase.

VLPS: Virus-Like Particle.

LTRs: Long Terminal Repeat.

Species

Full-length genome architectures of representative semotiviruses. ORTR.Belpao.Fig1.v5-01.png
Full-length genome architectures of representative semotiviruses.

The genus contains the following species, listed by scientific name and followed by their common names: [13]

References

  1. Krupovic, M; Blomberg, J; Coffin, JM; Dasgupta, I; Fan, H; Geering, AD; Gifford, R; Harrach, B; Hull, R; Johnson, W; Kreuze, JF; Lindemann, D; Llorens, C; Lockhart, B; Mayer, J; Muller, E; Olszewski, N; Pappu, HR; Pooggin, M; Richert-Pöggeler, KR; Sabanadzovic, S; Sanfaçon, H; Schoelz, JE; Seal, S; Stavolone, L; Stoye, JP; Teycheney, PY; Tristem, M; Koonin, EV; Kuhn, JH (4 April 2018). "Ortervirales: A new viral order unifying five families of reverse-transcribing viruses". Journal of Virology. 92 (12). doi:10.1128/JVI.00515-18. PMC   5974489 . PMID   29618642.
  2. "Genus: Semotivirus | ICTV". ictv.global. Retrieved 2024-10-13.
  3. Llorens, Carlos; Soriano, Beatriz; Krupovic, Mart; ICTV Report Consortium (2021). "ICTV Virus Taxonomy Profile: Pseudoviridae". Journal of General Virology. 102 (3): 001563. doi:10.1099/jgv.0.001563. ISSN   1465-2099. PMC   8515867 . PMID   33528349.
  4. Soriano, Beatriz; Krupovic, Mart; Llorens, Carlos (2021). "ICTV Virus Taxonomy Profile: Belpaoviridae 2021". Journal of General Virology. 102 (11): 001688. doi:10.1099/jgv.0.001688. ISSN   1465-2099. PMC   8742986 . PMID   34761738.
  5. Llorens, Carlos; Soriano, Beatriz; Krupovic, Mart; ICTV Report Consortium (2020). "ICTV Virus Taxonomy Profile: Metaviridae". Journal of General Virology. 101 (11): 1131–1132. doi:10.1099/jgv.0.001509. ISSN   1465-2099. PMC   7879559 . PMID   33048045.
  6. Llorens, C.; Futami, R.; Covelli, L.; Dominguez-Escriba, L.; Viu, J. M.; Tamarit, D.; Aguilar-Rodriguez, J.; Vicente-Ripolles, M.; Fuster, G.; Bernet, G. P.; Maumus, F.; Munoz-Pomer, A.; Sempere, J. M.; Latorre, A.; Moya, A. (2010-10-29). "The Gypsy Database (GyDB) of mobile genetic elements: release 2.0". Nucleic Acids Research. 39 (Database): D70 –D74. doi:10.1093/nar/gkq1061. ISSN   0305-1048. PMC   3013669 . PMID   21036865.
  7. Massimiliano Marsano, Renè; Caizzi, Ruggiero (2005-09-12). "A genome-wide screening of BEL-Pao like retrotransposons in Anopheles gambiae by the LTR_STRUC program" . Gene. 357 (2): 115–121. doi:10.1016/j.gene.2005.06.010. ISSN   0378-1119. PMID   16102916.
  8. Krupovic, Mart; Blomberg, Jonas; Coffin, John M.; Dasgupta, Indranil; Fan, Hung; Geering, Andrew D.; Gifford, Robert; Harrach, Balázs; Hull, Roger; Johnson, Welkin; Kreuze, Jan F.; Lindemann, Dirk; Llorens, Carlos; Lockhart, Ben; Mayer, Jens (2018-06-15). "Ortervirales: New Virus Order Unifying Five Families of Reverse-Transcribing Viruses". Journal of Virology. 92 (12). doi:10.1128/JVI.00515-18. ISSN   0022-538X. PMC   5974489 . PMID   29618642.
  9. Krupovic, Mart; Koonin, Eugene V. (2017-06-15). "Homologous Capsid Proteins Testify to the Common Ancestry of Retroviruses, Caulimoviruses, Pseudoviruses, and Metaviruses". Journal of Virology. 91 (12). doi:10.1128/JVI.00210-17. ISSN   0022-538X. PMC   5446648 . PMID   28356531.
  10. de la Chaux, Nicole; Wagner, Andreas (2011-06-04). "BEL/Pao retrotransposons in metazoan genomes". BMC Evolutionary Biology. 11 (1): 154. Bibcode:2011BMCEE..11..154D. doi: 10.1186/1471-2148-11-154 . ISSN   1471-2148. PMC   3118150 . PMID   21639932.
  11. Llorens, Carlos; Soriano, Beatriz; Krupovic, Mart; ICTV Report Consortium (2020). "ICTV Virus Taxonomy Profile: Metaviridae". Journal of General Virology. 101 (11): 1131–1132. doi:10.1099/jgv.0.001509. ISSN   1465-2099. PMC   7879559 . PMID   33048045.
  12. Soriano, Beatriz; Krupovic, Mart; Llorens, Carlos (2021). "ICTV Virus Taxonomy Profile: Belpaoviridae 2021". Journal of General Virology. 102 (11). doi:10.1099/jgv.0.001688. PMC   8742986 . PMID   34761738.
  13. "Virus Taxonomy: 2024 Release". International Committee on Taxonomy of Viruses. Retrieved 22 March 2025.