Rhadinovirus is a genus of viruses in the order Herpesvirales, in the family Herpesviridae, in the subfamily Gammaherpesvirinae. Humans and other mammals serve as natural hosts. There are 12 species in this genus. Diseases associated with this genus include: Kaposi's sarcoma, primary effusion lymphoma and multicentric Castleman's disease, caused by Human gammaherpesvirus 8 (HHV-8), also known as Kaposi's sarcoma-associated herpesvirus (KSHV). The term rhadino comes from the Latin fragile, referring to the tendency of the viral genome to break apart when it is isolated.
Herpesviridae is a large family of DNA viruses that cause infections and certain diseases in animals, including humans. The members of this family are also known as herpesviruses. The family name is derived from the Greek word ἕρπειν, referring to spreading cutaneous lesions, usually involving blisters, seen in flares of herpes simplex 1, herpes simplex 2 and herpes zoster (shingles). In 1971, the International Committee on the Taxonomy of Viruses (ICTV) established Herpesvirus as a genus with 23 viruses among four groups. As of 2020, 115 species are recognized, all but one of which are in one of the three subfamilies. Herpesviruses can cause both latent and lytic infections.
Equid alphaherpesvirus 3, formerly Equine herpesvirus 3 (EHV-3), is a virus of the family Herpesviridae that affects horses.
Equid alphaherpesvirus 4, formerly Equine herpesvirus 4 (EHV-4) is a virus of the family Herpesviridae that cause rhinopneumonitis in horses. It is the most important viral cause of respiratory infection in foals. Like other herpes viruses, EHV-4 causes a lifelong latent infection in affected animals. These horses are usually the source for new infection for foals over two months old, weanlings, and yearlings. Symptoms include fever, loss of appetite, and discharge from the nose. Most infected animals recover in one to three weeks, but death can occur in environments with overcrowding and other stress factors. There are several vaccines available.
Equid alphaherpesvirus 1, formerly Equine herpesvirus 1 (EHV-1), is a virus of the family Herpesviridae that causes abortion, respiratory disease and occasionally neonatal mortality in horses. Initial spread of EHV-1 by a newly introduced horse through direct and indirect contact can lead to abortion and perinatal infection in up to 70 percent of a previously unexposed herd. Abortion usually occurs in the last four months of gestation, two to four weeks after infection of the mare. Perinatal infection can lead to pneumonia and death. Encephalitis can occur in affected animals, leading to ataxia, paralysis, and death. There is a vaccine available, however its efficacy is questionable. The virus varies in severity from sub-clinical to very severe. Most horses have been infected with EHV-1, but the virus can become latent and persist without ever causing signs of infection. In 2006, an outbreak of EHV-1 among stables in Florida resulted in the institution of quarantine measures. The outbreak was determined to have originated in horses imported from Europe via New York, before being shipped to Florida.
Gammaherpesvirinae is a subfamily of viruses in the order Herpesvirales and in the family Herpesviridae. Viruses in Gammaherpesvirinae are distinguished by reproducing at a more variable rate than other subfamilies of Herpesviridae. Mammals serve as natural hosts. There are 43 species in this subfamily, divided among 7 genera with three species unassigned to a genus. Diseases associated with this subfamily include: HHV-4: infectious mononucleosis. HHV-8: Kaposi's sarcoma.
Lymphocryptovirus is a genus of viruses in the order Herpesvirales, in the family Herpesviridae, in the subfamily Gammaherpesvirinae. This genus includes the human-infecting Human gammaherpesvirus 4, as well as viruses that infect both Old World monkeys and New World monkeys. Other names for the Lymphocryptovirus genus include Lymphocryptoviridae and gamma-1 herpesviruses. There are nine species in this genus. Diseases associated with this genus include: mononucleosis, Burkitt's lymphoma, and nasopharyngeal carcinoma.
The Herpesvirales is an order of dsDNA viruses with animal hosts, characterised by a common morphology consisting of an icosahedral capsid enclosed in a glycoprotein-containing lipid envelope. Common infections in humans caused by members of this order include cold sores, genital herpes, chickenpox, shingles, and glandular fever. Herpesvirales is the sole order in the class Herviviricetes, which is the sole class in the phylum Peploviricota.
Bovine gammaherpesvirus 4 (BoHV-4) is a member of the Herpesviridae family. It is part of the subfamily Gammaherpesvirinae and genus Rhadinovirus. Infection is normally sub-clinical but can cause reproductive disease in cattle such as endometritis, vulvovaginitis and mastitis. Transmission is both vertical and horizontal. It can also be indirectly spread by fomites. Distribution is worldwide and the virus infects a range of ruminants, including bison, buffalo, sheep and goats.
Equine alphaherpesvirus 9 (EHV-9) is a species of virus in the genus Varicellovirus, subfamily Alphaherpesvirinae, family Herpesviridae, and order Herpesvirales. It was first isolated from a case of epizootic encephalitis in a herd of Thomson's gazelle in 1993. Fatal encephalitis was reported from Thomson's gazelle, giraffe, and polar bear in natural infections. The virus was reported in an aborted Persian onager and a polar bear.
Equine multinodular pulmonary fibrosis is a chronic lung disease of horses. There is evidence that the disease is caused by infection with a gammaherpesvirus, equine herpesvirus 5. The disease affects usually adult horses reducing the ability to exercise as a result of the formation of nodular lesions in the lungs.
Equid gammaherpesvirus 5 (EHV-5), formerly Equine herpesvirus 5, is a species of virus in the genus Percavirus, subfamily Gammaherpesvirinae, family Herpesviridae, and order Herpesvirales. It is thought to be the cause of a chronic lung disease of adult horses; equine multinodular pulmonary fibrosis.
Percavirus is a genus of viruses in the order Herpesvirales, in the family Herpesviridae, in the subfamily Gammaherpesvirinae. Mammals serve as natural hosts. There are six species in this genus. Diseases associated with this genus include: conjunctivitis, immunosuppression in foals, pneumonia, respiratory disease.
Macropodid alphaherpesvirus 1 (MaHV-1) is a species of herpesvirus in the genus Simplexvirus. It was officially accepted as a valid species by the International Committee on Taxonomy of Viruses in 2004.
Macropodid alphaherpesvirus 2 (MaHV-2) is a species of herpesvirus in the genus Simplexvirus. It was officially accepted as a valid species by the International Committee on Taxonomy of Viruses in 2004.
Gorilline gammaherpesvirus 1 (GoHV-1), commonly known as herpesvirus gorilla is a species of virus in the genus Lymphocryptovirus, subfamily Gammaherpesvirinae, family Herpesviridae, and order Herpesvirales.
Pongine gammaherpesvirus 2 (PoHV-2), commonly known as orangutan herpesvirus, is a species of virus in the genus Lymphocryptovirus, subfamily Gammaherpesvirinae, family Herpesviridae, and order Herpesvirales.
Ateline gammaherpesvirus 2 (AtHV-2) is a species of virus in the genus Rhadinovirus, subfamily Gammaherpesvirinae, family Herpesviridae, and order Herpesvirales.
Saimiriine gammaherpesvirus 2 (SaHV-2) is a species of virus in the genus Rhadinovirus, subfamily Gammaherpesvirinae, family Herpesviridae, and order Herpesvirales.
Equid gammaherpesvirus 7 (EHV-7) is a species of virus of uncertain generic placement in the subfamily Gammaherpesvirinae, family Herpesviridae, and order Herpesvirales.
