Simplexvirus

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Simplexvirus
HSV-1-EM.png
3D computer reconstruction of a Human alphaherpesvirus 1 capsid
Virus classification OOjs UI icon edit-ltr.svg
(unranked): Virus
Realm: Duplodnaviria
Kingdom: Heunggongvirae
Phylum: Peploviricota
Class: Herviviricetes
Order: Herpesvirales
Family: Orthoherpesviridae
Subfamily: Alphaherpesvirinae
Genus:Simplexvirus
Species

See text

Simplexvirus is a genus of viruses in the order Herpesvirales , in the family Herpesviridae , in the subfamily Alphaherpesvirinae . Humans and mammals serve as natural hosts. Diseases associated with this genus include skin vesicles or mucosal ulcers, rarely encephalitis, and meningitis. [1] [2]

Contents

Species

The following 17 species are assigned to the genus in ICTV 2022: [2]

Structure

Viruses in Simplexvirus are enveloped, with icosahedral, spherical to pleomorphic, and round geometries, and T=16 symmetry. The diameter is around 150-200 nm. Genomes are linear and unsegmented, around 152kb in length. [1]

GenusStructureSymmetryCapsidGenomic arrangementGenomic segmentation
SimplexvirusSpherical pleomorphicT=16EnvelopedLinearMonopartite

Lifecycle

Viral replication is nuclear, and is lysogenic. Entry into the host cell is achieved by attachment of the viral gB, gC, gD, and gH proteins to host receptors, which mediates endocytosis. Replication follows the dsDNA bidirectional replication model. DNA-templated transcription, with some alternative splicing mechanism, is the method of transcription. Translation takes place by leaky scanning. The virus exits the host cell by nuclear egress, budding, and microtubular outwards viral transport. Human and mammals serve as the natural hosts. Transmission routes are sexual, contact, and saliva. [1]

GenusHost detailsTissue tropismEntry detailsRelease detailsReplication siteAssembly siteTransmission
SimplexvirusHumans; mammalsEpithelial mucosaCell receptor endocytosisBuddingNucleusNucleusSaliva

Related Research Articles

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<i>Alphaherpesvirinae</i> Subfamily of viruses

Alphaherpesvirinae is a subfamily of viruses in the family Herpesviridae, primarily distinguished by reproducing more quickly than other subfamilies in the Herpesviridae. In animal virology the most important herpesviruses belong to the Alphaherpesvirinae. Pseudorabies virus is the causative agent of Aujeszky's disease in pigs and Bovine herpesvirus 1 is the causative agent of bovine infectious rhinotracheitis and pustular vulvovaginitis. Mammals serve as natural hosts. There are currently 45 species in this subfamily, divided among 5 genera with one species unassigned to a genus. Diseases associated with this subfamily include: HHV-1 and HHV-2: skin vesicles or mucosal ulcers, rarely encephalitis and meningitis, HHV-3: chickenpox (varicella) and shingles, GaHV-2: Marek's disease.

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<i>Iltovirus</i> Genus of viruses

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<i>Orthohepadnavirus</i> Genus of viruses

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Alphapapillomavirus is a genus of viruses, in the family Papillomaviridae. Human and monkeys serve as natural hosts. There are 14 species in this genus. Diseases associated with this genus include: warts, papilloma, malignant tumours. Genital-type, high-risk of malignancy : HPV-16, 18. Genital-type, low-risk of malignancy : HPV-6, 11.

Betapapillomavirus is a genus of viruses, in the family Papillomaviridae. Human serve as natural hosts. There are six species in this genus. Diseases associated with this genus include warts, papilloma, and malignant tumours.

Etapapillomavirus is a genus of viruses, in the family Papillomaviridae. Birds serve as natural hosts. There is only one species in this genus: Etapapillomavirus 1. Diseases associated with this genus include: causes cutaneous lesions.

Gammapapillomavirus is a genus of viruses, in the family Papillomaviridae. Human serve as natural hosts. There are 27 species in this genus. Diseases associated with this genus include: warts, papilloma.

Macavirus is a genus of viruses in the order Herpesvirales, in the family Herpesviridae, in the subfamily Gammaherpesvirinae. Mammals serve as natural hosts. There are nine species in this genus. Diseases associated with this genus include: inapparent infection in their reservoir hosts, but fatal lymphoproliferative disease when they infect MCF-susceptible hosts, including cattle, deer, bison, water buffalo and pigs.

Nupapillomavirus is a genus of viruses, in the family Papillomaviridae. Humans serve as natural hosts. There is only one species in this genus: Nupapillomavirus 1. Diseases associated with this genus include: facial warts. It has also been detected in some skin carcinomas and premalignant keratoses.

Percavirus is a genus of viruses in the order Herpesvirales, in the family Herpesviridae, in the subfamily Gammaherpesvirinae. Mammals serve as natural hosts. There are six species in this genus. Diseases associated with this genus include: conjunctivitis, immunosuppression in foals, pneumonia, respiratory disease.

Scutavirus is a genus of viruses in the order Herpesvirales, in the family Herpesviridae, in the subfamily Alphaherpesvirinae. Turtles and tortoises serve as natural hosts. Diseases associated with this genus include fibropapillomatosis.

Batravirus is a genus of viruses in the order Herpesvirales, in the family Alloherpesviridae. Frogs serve as natural hosts. There are three species in this genus. Diseases associated with this genus include: raHV-1: Lucké tumor.

References

  1. 1 2 3 "Viral Zone". ExPASy. Retrieved 15 June 2015.
  2. 1 2 "Virus Taxonomy: 2022 Release". International Committee on Taxonomy of Viruses (ICTV). March 2023. Retrieved 16 September 2022.