Frontonasal process

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Frontonasal process
Gray44.png
Under surface of the head of a human embryo about twenty-nine days old. (Frontonasal process labeled at center left.)
Details
Precursor Ectoderm
Identifiers
TE process_by_E5.3.0.0.0.0.6 E5.3.0.0.0.0.6
Anatomical terminology

The frontonasal process or frontonasal prominence is one of the five swellings that develop to form the face. The frontonasal process is unpaired, and the others are the paired maxillary prominences, and the paired mandibular prominences. During the fourth week of embryonic development, an area of thickened ectoderm develops, on each side of the frontonasal process called the nasal placodes or olfactory placodes, and appear immediately under the forebrain. [1]

Contents

By invagination these areas are converted into two nasal pits, which indent the frontonasal prominence and divide it into medial and lateral nasal processes. [2]

Nasal processes

Medial and lateral nasal processes shown on embryo. Gray45.png
Medial and lateral nasal processes shown on embryo.

The medial nasal process (nasomedial) on the inner side of each nasal pit merge into the intermaxillary segment and form the upper lip, crest, and tip of the nose. [1] The medial nasal processes merge with the maxillary prominences. The lateral nasal process from each side merge to form the alae of the nose. [1]

Clinical significance

Failure to fuse can cause a cleft lip. [1]

Genetics

There is some evidence that development involves Sonic hedgehog and Fibroblast growth factor 8. [3]

Related Research Articles

<span class="mw-page-title-main">Maxilla</span> Upper jaw bone

In vertebrates, the maxilla is the upper fixed bone of the jaw formed from the fusion of two maxillary bones. In humans, the upper jaw includes the hard palate in the front of the mouth. The two maxillary bones are fused at the intermaxillary suture, forming the anterior nasal spine. This is similar to the mandible, which is also a fusion of two mandibular bones at the mandibular symphysis. The mandible is the movable part of the jaw.

<span class="mw-page-title-main">Sphenoid bone</span> Bone of the neurocranium

The sphenoid bone is an unpaired bone of the neurocranium. It is situated in the middle of the skull towards the front, in front of the basilar part of the occipital bone. The sphenoid bone is one of the seven bones that articulate to form the orbit. Its shape somewhat resembles that of a butterfly or bat with its wings extended.

<span class="mw-page-title-main">Lacrimal bone</span> Smallest and most fragile bone of the human skull and face

The lacrimal bones are two small and fragile bones of the facial skeleton; they are roughly the size of the little fingernail and situated at the front part of the medial wall of the orbit. They each have two surfaces and four borders. Several bony landmarks of the lacrimal bones function in the process of lacrimation. Specifically, the lacrimal bones help form the nasolacrimal canal necessary for tear translocation. A depression on the anterior inferior portion of one bone, the lacrimal fossa, houses the membranous lacrimal sac. Tears, from the lacrimal glands, collect in this sac during excessive lacrimation. The fluid then flows through the nasolacrimal duct and into the nasopharynx. This drainage results in what is commonly referred to a runny nose during excessive crying or tear production. Injury or fracture of the lacrimal bone can result in posttraumatic obstruction of the lacrimal pathways.

<span class="mw-page-title-main">Inferior nasal concha</span> Facial bone

The inferior nasal concha is one of the three paired nasal conchae in the nose. It extends horizontally along the lateral wall of the nasal cavity and consists of a lamina of spongy bone, curled upon itself like a scroll,. The inferior nasal conchae are considered a pair of facial bones. As the air passes through the turbinates, the air is churned against these mucosa-lined bones in order to receive warmth, moisture and cleansing. Superior to inferior nasal concha are the middle nasal concha and superior nasal concha which both arise from the ethmoid bone, of the cranial portion of the skull. Hence, these two are considered as a part of the cranial bones.

<span class="mw-page-title-main">Vomer</span> Unpaired facial bone of the skull

The vomer is one of the unpaired facial bones of the skull. It is located in the midsagittal line, and articulates with the sphenoid, the ethmoid, the left and right palatine bones, and the left and right maxillary bones. The vomer forms the inferior part of the nasal septum in humans, with the superior part formed by the perpendicular plate of the ethmoid bone. The name is derived from the Latin word for a ploughshare and the shape of the bone.

<span class="mw-page-title-main">Nasal cavity</span> Large, air-filled space above and behind the nose in the middle of the face

The nasal cavity is a large, air-filled space above and behind the nose in the middle of the face. The nasal septum divides the cavity into two cavities, also known as fossae. Each cavity is the continuation of one of the two nostrils. The nasal cavity is the uppermost part of the respiratory system and provides the nasal passage for inhaled air from the nostrils to the nasopharynx and rest of the respiratory tract.

<span class="mw-page-title-main">Nasolacrimal duct</span> Carries tears from the lacrimal sac of the eye into the nasal cavity.

The nasolacrimal duct carries tears from the lacrimal sac of the eye into the nasal cavity. The duct begins in the eye socket between the maxillary and lacrimal bones, from where it passes downwards and backwards. The opening of the nasolacrimal duct into the inferior nasal meatus of the nasal cavity is partially covered by a mucosal fold.

<span class="mw-page-title-main">Maxillary sinus</span> Largest of the paranasal sinuses, and drains into the middle meatus of the nose

The pyramid-shaped maxillary sinus is the largest of the paranasal sinuses, located in the maxilla. It drains into the middle meatus of the nose through the semilunar hiatus. It is located to the side of the nasal cavity, and below the orbit.

<span class="mw-page-title-main">Pharyngeal arch</span> Embryonic precursor structures in vertebrates

The pharyngeal arches, also known as visceral arches, are structures seen in the embryonic development of vertebrates that are recognisable precursors for many structures. In fish, the arches are known as the branchial arches, or gill arches.

<span class="mw-page-title-main">Pterygopalatine fossa</span> Fossa in the skull

In human anatomy, the pterygopalatine fossa is a fossa in the skull. A human skull contains two pterygopalatine fossae—one on the left side, and another on the right side. Each fossa is a cone-shaped paired depression deep to the infratemporal fossa and posterior to the maxilla on each side of the skull, located between the pterygoid process and the maxillary tuberosity close to the apex of the orbit. It is the indented area medial to the pterygomaxillary fissure leading into the sphenopalatine foramen. It communicates with the nasal and oral cavities, infratemporal fossa, orbit, pharynx, and middle cranial fossa through eight foramina.

<span class="mw-page-title-main">Ethmoidal labyrinth</span>

The ethmoidal labyrinth or lateral mass of the ethmoid bone consists of a number of thin-walled cellular cavities, the ethmoid air cells, arranged in three groups, anterior, middle, and posterior, and interposed between two vertical plates of bone; the lateral plate forms part of the orbit, the medial plate forms part of the nasal cavity. In the disarticulated bone many of these cells are opened into, but when the bones are articulated, they are closed in at every part, except where they open into the nasal cavity.

<span class="mw-page-title-main">Squamous part of the frontal bone</span> Upper two-thirds of the forward skull

The squamous part of the frontal bone is the superior portion when viewed in standard anatomical orientation. There are two surfaces of the squamous part of the frontal bone: the external surface, and the internal surface.

In embryology, Carnegie stages are a standardized system of 23 stages used to provide a unified developmental chronology of the vertebrate embryo.

<span class="mw-page-title-main">Maxillary prominence</span>

Continuous with the dorsal end of the first pharyngeal arch, and growing forward from its cephalic border, is a triangular process, the maxillary prominence, the ventral extremity of which is separated from the mandibular arch by a ">"-shaped notch.

<span class="mw-page-title-main">Ethmoidal infundibulum</span>

The ethmoidal infundibulum is a funnel-shaped/slit-like/curved opening/passage/space/cleft upon the anterosuperior portion of the middle nasal meatus at the hiatus semilunaris. The anterior ethmoidal air cells, and (usually) the frontonasal duct open into the ethmoidal infundibulum. The ethmoidal infundibulum extends anterosuperiorly from its opening into the nasal cavity.

<span class="mw-page-title-main">Human nose</span> Feature of the human face

The human nose is the first organ of the respiratory system. It is also the principal organ in the olfactory system. The shape of the nose is determined by the nasal bones and the nasal cartilages, including the nasal septum, which separates the nostrils and divides the nasal cavity into two.

<span class="mw-page-title-main">Nasal placode</span>

The nasal placode gives rise to the olfactory epithelium of the nose. Two nasal placodes arise as thickened ectoderm from the frontonasal process. They give rise to the nose, the philtrum of the upper lip, and the primary palate.

<span class="mw-page-title-main">Premaxilla</span> Cranial bones at the very tip of the upper jaw of many animals

The premaxilla is one of a pair of small cranial bones at the very tip of the upper jaw of many animals, usually, but not always, bearing teeth. In humans, they are fused with the maxilla. The "premaxilla" of therian mammals has been usually termed as the incisive bone. Other terms used for this structure include premaxillary bone or os premaxillare, intermaxillary bone or os intermaxillare, and Goethe's bone.

<span class="mw-page-title-main">Frontonasal dysplasia</span> Medical condition

Frontonasal dysplasia (FND) is a congenital malformation of the midface. For the diagnosis of FND, a patient should present at least two of the following characteristics: hypertelorism, a wide nasal root, vertical midline cleft of the nose and/or upper lip, cleft of the wings of the nose, malformed nasal tip, encephalocele or V-shaped hair pattern on the forehead. The cause of FND remains unknown. FND seems to be sporadic (random) and multiple environmental factors are suggested as possible causes for the syndrome. However, in some families multiple cases of FND were reported, which suggests a genetic cause of FND.

The face and neck development of the human embryo refers to the development of the structures from the third to eighth week that give rise to the future head and neck. They consist of three layers, the ectoderm, mesoderm and endoderm, which form the mesenchyme, neural crest and neural placodes. The paraxial mesoderm forms structures named somites and somitomeres that contribute to the development of the floor of the brain and voluntary muscles of the craniofacial region. The lateral plate mesoderm consists of the laryngeal cartilages. The three tissue layers give rise to the pharyngeal apparatus, formed by six pairs of pharyngeal arches, a set of pharyngeal pouches and pharyngeal grooves, which are the most typical feature in development of the head and neck. The formation of each region of the face and neck is due to the migration of the neural crest cells which come from the ectoderm. These cells determine the future structure to develop in each pharyngeal arch. Eventually, they also form the neurectoderm, which forms the forebrain, midbrain and hindbrain, cartilage, bone, dentin, tendon, dermis, pia mater and arachnoid mater, sensory neurons, and glandular stroma.

References

PD-icon.svgThis article incorporates text in the public domain from page 67 of the 20th edition of Gray's Anatomy (1918)

  1. 1 2 3 4 Sadler, T (2006). Langman's Medical Embryology. pp. 280–284. ISBN   9780781790697.
  2. Larsen, W (2001). Human embryology. pp. 365–368. ISBN   0443065837.
  3. Abzhanov A, Cordero DR, Sen J, Tabin CJ, Helms JA (December 2007). "Cross-regulatory interactions between Fgf8 and Shh in the avian frontonasal prominence". Congenit Anom (Kyoto). 47 (4): 136–48. doi:10.1111/j.1741-4520.2007.00162.x. PMID   17988255. S2CID   16272570.