Frontoparietal network

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The salience network is theorised to mediate switching between the default mode network and frontoparietal network (central executive network). Fnbeh-08-00171-g002.jpg
The salience network is theorised to mediate switching between the default mode network and frontoparietal network (central executive network).

The frontoparietal network (FPN), generally also known as the central executive network (CEN) or, more specifically, the lateral frontoparietal network (L-FPN) (see Nomenclature), is a large-scale brain network primarily composed of the dorsolateral prefrontal cortex and posterior parietal cortex, [4] around the intraparietal sulcus. [5] It is involved in sustained attention, complex problem-solving and working memory. [1]

Contents

The FPN is one of three networks in the so-called triple-network model, along with the salience network and the default mode network (DMN). [6] The salience network facilitates switching between the FPN and DMN. [1] [2]

Anatomy

The FPN is primarily composed of the rostral lateral and dorsolateral prefrontal cortex (especially the middle frontal gyrus) and the anterior inferior parietal lobule. Additional regions include the middle cingulate gyrus and potentially the dorsal precuneus, posterior inferior temporal lobe, dorsomedial thalamus and the head of the caudate nucleus. [7]

Function

The FPN is involved in executive function and goal-oriented, cognitively demanding tasks. [7] It is crucial for rule-based problem solving, actively maintaining and manipulating information in working memory and making decisions in the context of goal-directed behaviour. [1] Based on current cognitive demands, the FPN flexibly divides into two subsystems that connect to other networks: the default mode network for introspective processes and the dorsal attention network for perceptual attention. [8]

Clinical significance

Disruption of the nodes of the FPN has been found in virtually every psychiatric and neurological disorder, from autism, schizophrenia and depression to frontotemporal dementia and Alzheimer's disease. [1]

Nomenclature

The term central executive network (CEN) is generally equivalent to the frontoparietal network in literature, [9] [10] [11] distinguishing it from the dorsal attention network (DAN), with which it has several similarities, [5] though sometimes it has been used to include the DAN. [11]

The FPN has fewer similarities with the salience network (which has also been equated with the cingulo-opercular network or ventral attention network [7] ). Regardless, it has sometimes been grouped together with either the DAN or the salience network (usually the latter [12] ) under the name executive control network (ECN). [5] The term frontoparietal control network (FPCN) has also been used, generally also for a grouping of the FPN and the salience network. [5] [12]

Other names for the FPN have included the multiple-demand system, extrinsic mode network, domain-general system and cognitive control network. [7]

In 2019, Uddin et al. proposed that lateral frontoparietal network (L-FPN) be used as the standard name for this network. [7]

See also

Related Research Articles

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<span class="mw-page-title-main">Cingulate cortex</span> Part of the brain within the cerebral cortex

The cingulate cortex is a part of the brain situated in the medial aspect of the cerebral cortex. The cingulate cortex includes the entire cingulate gyrus, which lies immediately above the corpus callosum, and the continuation of this in the cingulate sulcus. The cingulate cortex is usually considered part of the limbic lobe.

<span class="mw-page-title-main">Anterior cingulate cortex</span> Brain region

In the human brain, the anterior cingulate cortex (ACC) is the frontal part of the cingulate cortex that resembles a "collar" surrounding the frontal part of the corpus callosum. It consists of Brodmann areas 24, 32, and 33.

<span class="mw-page-title-main">Brodmann area 46</span>

Brodmann area 46, or BA46, is part of the frontal cortex in the human brain. It is between BA10 and BA45.

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<span class="mw-page-title-main">Angular gyrus</span> Gyrus of the parietal lobe of the brain

The angular gyrus is a region of the brain lying mainly in the posteroinferior region of the parietal lobe, occupying the posterior part of the inferior parietal lobule. It represents the Brodmann area 39.

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<span class="mw-page-title-main">Posterior cingulate cortex</span> Caudal part of the cingulate cortex of the brain

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The dorsal attention network (DAN), also known anatomically as the dorsal frontoparietal network (D-FPN), is a large-scale brain network of the human brain that is primarily composed of the intraparietal sulcus (IPS) and frontal eye fields (FEF). It is named and most known for its role in voluntary orienting of visuospatial attention.

<span class="mw-page-title-main">Dorsolateral prefrontal cortex</span> Area of the prefrontal cortex of primates

The dorsolateral prefrontal cortex is an area in the prefrontal cortex of the primate brain. It is one of the most recently derived parts of the human brain. It undergoes a prolonged period of maturation which lasts until adulthood. The DLPFC is not an anatomical structure, but rather a functional one. It lies in the middle frontal gyrus of humans. In macaque monkeys, it is around the principal sulcus. Other sources consider that DLPFC is attributed anatomically to BA 9 and 46 and BA 8, 9 and 10.

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In neuroscience, the default mode network (DMN), also known as the default network, default state network, or anatomically the medial frontoparietal network (M-FPN), is a large-scale brain network primarily composed of the dorsal medial prefrontal cortex, posterior cingulate cortex/precuneus and angular gyrus. It is best known for being active when a person is not focused on the outside world and the brain is at wakeful rest, such as during daydreaming and mind-wandering. It can also be active during detailed thoughts related to external task performance. Other times that the DMN is active include when the individual is thinking about others, thinking about themselves, remembering the past, and planning for the future.

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The dorsal nexus is an area within the dorsal medial prefrontal cortex that serves as an intersection point for multiple brain networks. Research suggests it plays a role in the maintenance and manipulation of information, as well as supporting the control of cognitive functions such as behavior, memory, and conflict resolution. Abnormally increased connectivity between these networks through the Dorsal Nexus has been associated with certain types of depression. The activity generated by this abnormally high level of connectivity during a depressive state can be identified through Magnetic resonance imaging (MRI) and Positron emission tomography (PET).

<span class="mw-page-title-main">Ventrolateral prefrontal cortex</span> Part of the prefrontal cortex of the brain

The ventrolateral prefrontal cortex (VLPFC) is a section of the prefrontal cortex located on the inferior frontal gyrus, bounded superiorly by the inferior frontal sulcus and inferiorly by the lateral sulcus. It is attributed to the anatomical structures of Brodmann's area (BA) 47, 45 and 44.

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References

  1. 1 2 3 4 5 Menon, Vinod (1 October 2011). "Large-scale brain networks and psychopathology: a unifying triple network model". Trends in Cognitive Sciences. 15 (10): 483–506. doi:10.1016/j.tics.2011.08.003. ISSN   1364-6613. PMID   21908230. S2CID   26653572.
  2. 1 2 Sridharan, D.; Levitin, D. J.; Menon, V. (22 August 2008). "A critical role for the right fronto-insular cortex in switching between central-executive and default-mode networks". Proceedings of the National Academy of Sciences. 105 (34): 12569–12574. Bibcode:2008PNAS..10512569S. doi: 10.1073/pnas.0800005105 . PMC   2527952 . PMID   18723676.
  3. Nekovarova, Tereza; Fajnerova, Iveta; Horacek, Jiri; Spaniel, Filip (30 May 2014). "Bridging disparate symptoms of schizophrenia: a triple network dysfunction theory". Frontiers in Behavioral Neuroscience. 8: 171. doi: 10.3389/fnbeh.2014.00171 . PMC   4038855 . PMID   24910597.
  4. Gong, Diankun; He, Hui; Ma, Weiyi; Liu, Dongbo; Huang, Mengting; Dong, Li; Gong, Jinnan; Li, Jianfu; Luo, Cheng (14 January 2016). "Functional Integration between Salience and Central Executive Networks: A Role for Action Video Game Experience". Neural Plasticity. 2016: 1–9. doi: 10.1155/2016/9803165 . PMC   4739029 . PMID   26885408.
  5. 1 2 3 4 Gratton, Caterina; Sun, Haoxin; Petersen, Steven E. (2018). "Control networks and hubs". Psychophysiology. 55 (3): e13032. doi:10.1111/psyp.13032. ISSN   1469-8986. PMC   5811327 . PMID   29193146.
  6. van Oort, J.; Tendolkar, I.; Hermans, E. J.; Mulders, P. C.; Beckmann, C. F.; Schene, A. H.; Fernández, G.; van Eijndhoven, P. F. (1 December 2017). "How the brain connects in response to acute stress: A review at the human brain systems level". Neuroscience & Biobehavioral Reviews. 83: 281–297. doi:10.1016/j.neubiorev.2017.10.015. ISSN   0149-7634. PMID   29074385. S2CID   35066027.
  7. 1 2 3 4 5 Uddin, Lucina Q.; Yeo, B. T. Thomas; Spreng, R. Nathan (1 November 2019). "Towards a Universal Taxonomy of Macro-scale Functional Human Brain Networks". Brain Topography. 32 (6): 926–942. doi:10.1007/s10548-019-00744-6. ISSN   1573-6792. PMC   7325607 . PMID   31707621.
  8. Dixon, ML; De La Vega, A; Mills, C; Andrews-Hanna, J; Spreng, RN; Cole, MW; Christoff, K (13 February 2018). "Heterogeneity within the frontoparietal control network and its relationship to the default and dorsal attention networks". Proceedings of the National Academy of Sciences of the United States of America. 115 (7): E1598–E1607. doi: 10.1073/pnas.1715766115 . PMC   5816169 . PMID   29382744.
  9. Philippi, Carissa L.; Pujara, Maia S.; Motzkin, Julian C.; Newman, Joseph; Kiehl, Kent A.; Koenigs, Michael (15 April 2015). "Altered Resting-State Functional Connectivity in Cortical Networks in Psychopathy". Journal of Neuroscience. 35 (15): 6068–6078. doi:10.1523/JNEUROSCI.5010-14.2015. ISSN   0270-6474. PMC   4397604 . PMID   25878280.
  10. Brodal, Per (2016). The Central Nervous System. Oxford University Press. p. 578. ISBN   978-0-19-022895-8.
  11. 1 2 Littow, Harri; Huossa, Ville; Karjalainen, Sami; Jääskeläinen, Erika; Haapea, Marianne; Miettunen, Jouko; Tervonen, Osmo; Isohanni, Matti; Nikkinen, Juha; Veijola, Juha; Murray, Graham (2015). "Aberrant Functional Connectivity in the Default Mode and Central Executive Networks in Subjects with Schizophrenia – A Whole-Brain Resting-State ICA Study". Frontiers in Psychiatry. 6: 26. doi: 10.3389/fpsyt.2015.00026 . ISSN   1664-0640. PMC   4341512 . PMID   25767449. S2CID   14879568.
  12. 1 2 Spreng, R. Nathan; Sepulcre, Jorge; Turner, Gary R.; Stevens, W. Dale; Schacter, Daniel L. (January 2013). "Intrinsic architecture underlying the relations among the default, dorsal attention, and frontoparietal control networks of the human brain". Journal of Cognitive Neuroscience. 25 (1): 74–86. doi:10.1162/jocn_a_00281. ISSN   0898-929X. PMC   3816715 . PMID   22905821.