Glutaconyl-CoA decarboxylase

glutaconyl-CoA decarboxylase
Identifiers
EC no.	4.1.1.70
CAS no.	84399-93-9
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Gene Ontology	AmiGO / QuickGO
Search PMC articles PubMed articles NCBI proteins

In enzymology, a glutaconyl-CoA decarboxylase (EC 4.1.1.70) is an enzyme that catalyzes the chemical reaction

4-carboxybut-2-enoyl-CoA ${\displaystyle \rightleftharpoons }$ but-2-enoyl-CoA + CO₂

Hence, this enzyme has one substrate, 4-carboxybut-2-enoyl-CoA, and two products, but-2-enoyl-CoA and CO₂.

This enzyme belongs to the family of lyases, specifically the carboxy-lyases, which cleave carbon-carbon bonds. The systematic name of this enzyme class is 4-carboxybut-2-enoyl-CoA carboxy-lyase (but-2-enoyl-CoA-forming). Other names in common use include glutaconyl coenzyme A decarboxylase, pent-2-enoyl-CoA carboxy-lyase, and 4-carboxybut-2-enoyl-CoA carboxy-lyase. This enzyme participates in benzoate degradation via coa ligation and butanoate metabolism.

Structural studies

As of late 2007, only one structure has been solved for this class of enzymes, with the PDB accession code 1PIX.

References

• Buckel W, Semmler R (1983). "Purification, characterisation and reconstitution of glutaconyl-CoA decarboxylase, a biotin-dependent sodium pump from anaerobic bacteria". Eur. J. Biochem. 136 (2): 427–34. doi: 10.1111/j.1432-1033.1983.tb07760.x . PMID   6628393.
• Buckel W (2001). "Sodium ion-translocating decarboxylases". Biochim. Biophys. Acta. 1505 (1): 15–27. doi:10.1016/s0005-2728(00)00273-5. PMID   11248185.