Godmania aesculifolia

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Godmania aesculifolia
Scientific classification Red Pencil Icon.png
Kingdom: Plantae
Clade: Tracheophytes
Clade: Angiosperms
Clade: Eudicots
Clade: Asterids
Order: Lamiales
Family: Bignoniaceae
Genus: Godmania
Species:
G. aesculifolia
Binomial name
Godmania aesculifolia
Synonyms
  • Bignonia aesculifoliaKunth
  • Cybistax macrocarpaBenth.
  • Godmania macrocarpa(Benth.) Hemsl.
  • Godmania uleanaKraenzl. Synonym
  • Tabebuia aesculifolia(Kunth) Hemsl.
  • Tabebuia fuscataHemsl.
  • Tabebuia globifloraErnst
  • Tecoma aesculifolia(Kunth) DC.
  • Tecoma digitataKunth
  • Tecoma fuscataDC.

Godmania aesculifolia is a species of flowering plant in the family Bignoniaceae, native to the New World tropics. [2] [3] [4] A tree, it contains 7,8-dihydroxyflavone, a flavonoid. [5]

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<span class="mw-page-title-main">Tropoflavin</span> Chemical compound

Tropoflavin, also known as 7,8-dihydroxyflavone, is a naturally occurring flavone found in Godmania aesculifolia, Tridax procumbens, and primula tree leaves. It has been found to act as a potent and selective small-molecule agonist of the tropomyosin receptor kinase B (TrkB), the main signaling receptor of the neurotrophin brain-derived neurotrophic factor (BDNF). Tropoflavin is both orally bioavailable and able to penetrate the blood–brain barrier. A prodrug of tropoflavin with greatly improved potency and pharmacokinetics, R13, is under development for the treatment of Alzheimer's disease.

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<span class="mw-page-title-main">R13 (drug)</span>

R13 is a small-molecule flavonoid and orally active, potent, and selective agonist of the tropomyosin receptor kinase B (TrkB) – the main signaling receptor for the neurotrophin brain-derived neurotrophic factor (BDNF) – which is under development for the potential treatment of Alzheimer's disease. It is a structural modification and prodrug of tropoflavin (7,8-DHF) with improved potency and pharmacokinetics, namely oral bioavailability and duration. The compound is a replacement for the earlier tropoflavin prodrug R7 and has similar properties to it. It was developed because while R7 displayed a good drug profile in animal studies, it showed almost no conversion into tropoflavin in human liver microsomes. In contrast to R7, R13 is readily hydrolyzed into tropoflavin in human liver microsomes.

References

  1. Botanic Gardens Conservation International (BGCI); IUCN SSC Global Tree Specialist Group (2019). "Godmania aesculifolia". IUCN Red List of Threatened Species . 2019: e.T144310894A149007266. doi: 10.2305/IUCN.UK.2019-2.RLTS.T144310894A149007266.en . Retrieved 30 December 2022.
  2. Grandtner, Miroslav Marian (2005). Elsevier's Dictionary of Trees. Vol. 1. Amsterdam: Elsevier. p. 382. ISBN   9780080460185.
  3. Wunderlin, R. P.; Hansen, B. F.; Franck, A. R.; Essig, F. B. (2022). "Atlas of Florida Plants". Atlas of Florida Plants. Institute for Systematic Botany, University of South Florida, Tampa. Retrieved October 30, 2022.
  4. Pérez, Rolando (n.d.). "CTFS plant photographic database image (Godmania aesculifolia)". Smithsonian Tropical Research Institute . Retrieved 30 October 2022.
  5. Emili, Marco; Guidi, Sandra; Uguagliati, Beatrice; Giacomini, Andrea; Bartesaghi, Renata; Stagni, Fiorenza (2022). "Treatment with the flavonoid 7,8-Dihydroxyflavone: A promising strategy for a constellation of body and brain disorders". Critical Reviews in Food Science and Nutrition. 62 (1): 13–50. doi:10.1080/10408398.2020.1810625. PMID   32914634. S2CID   221622738.