Gustav Nossal | |
---|---|
Born | Gustav Victor Joseph Nossal 4 June 1931 Bad Ischl, Austria |
Alma mater | University of Sydney (BSc), University of Melbourne (PhD) |
Known for | His contributions to the fields of antibody formation and immunological tolerance |
Awards | Albert Einstein World Award of Science (1990) |
Scientific career | |
Fields | Immunology |
Institutions | The Walter and Eliza Hall Institute of Medical Research, Melbourne |
Doctoral students | Michael F. Good |
Sir Gustav Victor Joseph Nossal AC CBE FRS FAA FTSE (born 4 June 1931) is an Austrian-born Australian research biologist. He is famous for his contributions to the fields of antibody formation and immunological tolerance.
Nossal's family was from Vienna, Austria. He was born four weeks prematurely in Bad Ischl while his mother was on holiday. His family left their home town of Vienna for Australia in 1939 following Nazi Germany's annexation of Austria. As his father's grandparents were Jewish, he was also considered Jewish and at risk of being sent to concentration camps. In an interview with Adam Spencer, Nossal noted that his father was not a professing Jew but of Jewish ethnicity as he had been baptised a Roman Catholic as a child. Nossal remarked that his father "therefore thought that he would be somewhat protected from the Holocaust-type predicament. Of course, he hadn't properly read Mein Kampf . It was all spelt out there: if your four grandparents were Jewish, then you were Jewish." [1] He was baptised and remains a practising Roman Catholic. [2]
Nossal showed interest in medicine and wanted to become a doctor since the age of seven. [3] When he first attended school in Australia, Nossal spoke no English [4] but he graduated from St Aloysius' College in 1947 [5] as the dux of the college. [6] In 1948, he entered the Sydney Medical School, graduating later with first-class honours from the University of Sydney. At the age of 26, he left his job in Sydney and moved to Melbourne to work with Macfarlane Burnet in medical science at the Walter and Eliza Hall Institute of Medical Research and gained his PhD degree at the University of Melbourne in 1960.
On describing his views on religion Nossal said:
For me, a large part of that is a tremendously strong identification with the mission of the Church. An instinct for justice is central to that mission and central to being a Catholic... Science deals with fundamentally repeatable, objective, verifiable observations. It deals with hypotheses of which you can at least say "this is not patently false." But the human experience, on the other hand, does not just deal with verifiable facts. The human experience has Shakespeare. It has Beethoven. It has Thomas Aquinas. There is no scientist alive who can tell me how the brain of Shakespeare differs from the brain of the worst scribbler for the tabloid press. This is not yet and may never be in the realm of science... We have to access this huge other area of human experience through other means. Call them the humanities. Theology, of course, is one of the great humanities. A human being struggling to understand the cosmos and to understand his or her own consciousness is not at all antipathetic or opposed to me struggling to understand how cells make antibody molecules.
— [2]
Following the retirement of Macfarlane Burnet in 1965, at the age of 35 Nossal became director of Walter and Eliza Hall Institute of Medical Research, a position that he kept until 1996. In parallel, he was Professor of Medical Biology at the University of Melbourne. Nossal's research was in fundamental immunology, in the field of "antibody formation and immunological tolerance". [7] He has written five books and 530 scientific articles in this and related fields.
Nossal has been President (1970-1973) of the 30,000-member world body of immunology, the International Union of Immunological Societies; President of the Australian Academy of Science (1994-1998); a member of the Prime Minister's Science, Engineering and Innovation Council (PMSEIC) (1989 to 1998); and Chairman of the Victorian Health Promotion Foundation (1987-1996). He has been chairman of the committee overseeing the World Health Organization's Vaccines and Biologicals Program (1993-2002) and Chairman of the Strategic Advisory Council of the Bill & Melinda Gates Foundation Children's Vaccine Program (1998-2003). He was Deputy Chairman of the Council for Aboriginal Reconciliation from 1998 to 2000. He was Chairman of the Advisory Committee of the Global Foundation, [8] The purpose of the foundation was to "encourage Australia’s sustainable national development in a global context." Sir Gustav is a member of the Patrons Council of the Epilepsy Foundation of Victoria and of the advisory board of the Health Impact Fund.
Nossal is married to Lyn whom he met and later married on completion of his medical course at the University of Sydney. Together, they have four children and nine grandchildren. [9] [10]
Sir Peter Brian Medawar was a British biologist and writer, whose works on graft rejection and the discovery of acquired immune tolerance have been fundamental to the medical practice of tissue and organ transplants. For his scientific works, he is regarded as the "father of transplantation". He is remembered for his wit both in person and in popular writings. Richard Dawkins referred to him as "the wittiest of all scientific writers"; Stephen Jay Gould as "the cleverest man I have ever known".
Sir Frank Macfarlane Burnet, usually known as Macfarlane or Mac Burnet, was an Australian virologist known for his contributions to immunology. He won a Nobel Prize in 1960 for predicting acquired immune tolerance and he developed the theory of clonal selection.
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Jerry McKee Adams, FAA, FRS, FAHMS, FRSV is an Australian-American molecular biologist whose research into the genetics of haemopoietic differentiation and malignancy, led him and his wife, Professor Suzanne Cory, to be the first two scientists to pioneer gene cloning techniques in Australia, and to successfully clone mammalian genes.
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In immunology, clonal selection theory explains the functions of cells of the immune system (lymphocytes) in response to specific antigens invading the body. The concept was introduced by Australian doctor Frank Macfarlane Burnet in 1957, in an attempt to explain the great diversity of antibodies formed during initiation of the immune response. The theory has become the widely accepted model for how the human immune system responds to infection and how certain types of B and T lymphocytes are selected for destruction of specific antigens.
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Suzanne Cory is an Australian molecular biologist. She has worked on the genetics of the immune system and cancer and has lobbied her country to invest in science. She is married to fellow scientist Jerry Adams, also a WEHI scientist, whom she met while studying for her PhD at the University of Cambridge, England.
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Ray David Owen was a teacher and scientist whose discovery of unusual, “mixed,” red blood cell types in cattle twins in 1945 launched the fields of modern immunology and organ transplantation. Owen's 1945 findings were published in the journal Science. This observation demonstrated that self was “learned” by the immune system during development and paved the way for research involving induction of immune tolerance and early tissue grafting. When Frank Macfarlane Burnet and Sir Peter Brian Medawar were awarded their 1960 Nobel Prize in Physiology or Medicine for the discovery of acquired immunological tolerance, Owen was not mentioned in the prize. However, in a letter to Owen, Medawar stated that he believed Owen should have also been included in the prize. Owen also led the successful effort to admit women as California Institute of Technology undergraduates.
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