Haplogroup V (mtDNA)

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Haplogroup V
Possible time of originOver 14,000 years BP [1]
Possible place of origin Europe (southwestern)
Ancestor HV0a
DescendantsV1, V2, V3, V4, V5, V6, V7, V8, V9, V10, V11, V12, V14, V15, V16, V17, V18, V22, V23, V24, V25, V26, V27, V28
Defining mutations4580 [2]

Haplogroup V is a human mitochondrial DNA (mtDNA) haplogroup. The clade is believed to have originated over 14,000 years ago in Southwestern Europe. [3] [4]

Contents

Origin

Haplogroup V derives from the HV0a subclade of haplogroup HV. In 1998 it was argued that V spread over Europe from an Ice Age refuge in Iberia. [3] However more recent estimates of the date of V would place it in the Neolithic. [1]

Distribution

Haplogroup V is a relatively rare mtDNA haplogroup, occurring in around 4% of native Europeans. [5] Its highest concentration is among the Saami people of northern Fennoscandia (~59%). It has been found at a frequency of approximately 10% among the Maris of the Volga-Ural region, leading to the suggestion that this region might be the source of the V among the Saami. [6] [7] Haplogroup V has been observed at higher than average levels among Cantabrian people (15%) of northern Iberia, [8] and among the adjacent Basque (10.4%). [9]

Haplogroup V is also found in parts of Northwest Africa. It is mainly concentrated among the Tuareg inhabiting the Gorom-Gorom area in Burkina Faso (21%), [10] Sahrawi in the Western Sahara (17.9%), [11] and Berbers of Matmata, Tunisia (16.3%). [12] The rare V7a subclade occurs among Algerians in Oran (1.08%) and Reguibate Sahrawi (1.85%). [13]

Ancient DNA

MtDNA haplogroup V has been reported in Neolithic remains of the Linear Pottery culture at Halberstadt, Germany c. 5000 BC [14] and Derenburg Meerenstieg, Germany c. 4910 BC. [15] Haplogroup V7 was found in representative Maykop culture samples in the excavations conducted by Alexei Rezepkin. [16] Haplogroup V has been detected in representatives Trypil'ska and Unetice culture. [17] [18]

Haplogroup V has also been found among Iberomaurusian specimens dating from the Epipaleolithic at the Taforalt prehistoric site 14,000 years BP. [19]

Haplogroup V has also been found among Somogyvár-Vinkovci culture specimens dating from the Bronze Age from Western Hungary https://www.biorxiv.org/content/10.1101/2022.02.03.478968v1.full.pdf

Tree

This phylogenetic tree of haplogroup V subclades is based on the paper by Mannis van Oven and Manfred Kayser Updated comprehensive phylogenetic tree of global human mitochondrial DNA variation [2] and subsequent published research.

See also

Phylogenetic tree of human mitochondrial DNA (mtDNA) haplogroups

  Mitochondrial Eve (L)  
L0 L1–6 
L1 L2   L3    L4 L5 L6
M N  
CZ D E G Q   O A S R   I W X Y
C Z B F R0   pre-JT   P   U
HV JT K
H V J T

References

  1. 1 2 Behar DM, et al. (2012). "A "Copernican" Reassessment of the Human Mitochondrial DNA Tree from its Root". The American Journal of Human Genetics. 90 (4): 675–684. doi:10.1016/j.ajhg.2012.03.002. PMC   3322232 . PMID   22482806.
  2. 1 2 van Oven M, Kayser M (Feb 2009). "Updated comprehensive phylogenetic tree of global human mitochondrial DNA variation". Human Mutation. 30 (2): E386–94. doi: 10.1002/humu.20921 . PMID   18853457. S2CID   27566749.
  3. 1 2 Torroni A, et al. (1998). "mtDNA Analysis Reveals a Major Late Paleolithic Population Expansion from Southwestern to Northeastern Europe". American Journal of Human Genetics. 62 (5): 1137–1152. doi:10.1086/301822. PMC   1377079 . PMID   9545392.
  4. Brandstätter, Anita; Zimmermann, Bettina; Wagner, Janine; Göbel, Tanja; Röck, Alexander W.; Salas, Antonio; Carracedo, Angel; Parson, Walther (2008-07-04). "Timing and deciphering mitochondrial DNA macro-haplogroup R0 variability in Central Europe and Middle East". BMC Evolutionary Biology. 8 (1): 191. Bibcode:2008BMCEE...8..191B. doi: 10.1186/1471-2148-8-191 . ISSN   1471-2148. PMC   2491632 . PMID   18601722.
  5. Bryan Sykes (2001). The Seven Daughters of Eve. London; New York: Bantam Press. ISBN   978-0393020182.
  6. Ingman M, Gyllensten U (2007). "A recent genetic link between Sami and the Volga-Ural region of Russia". European Journal of Human Genetics. 15 (1): 115–120. doi: 10.1038/sj.ejhg.5201712 . PMID   16985502.
  7. Tambets K, Rootsi S, Kivisild T, Help H, Serk P, et al. (2004). "The Western and Eastern Roots of the Saami—the Story of Genetic "Outliers" Told by Mitochondrial DNA and Y Chromosomes". American Journal of Human Genetics. 74 (4): 661–682. doi:10.1086/383203. PMC   1181943 . PMID   15024688.
  8. Maca-Meyer N, Sánchez-Velasco P, Flores C, Larruga JM, González AM, Oterino A, Leyva-Cobián F (Jul 2003). "Y chromosome and mitochondrial DNA characterization of Pasiegos, a human isolate from Cantabria (Spain)" (PDF). Annals of Human Genetics. 67 (Pt 4): 329–39. CiteSeerX   10.1.1.584.4253 . doi:10.1046/j.1469-1809.2003.00045.x. PMID   12914567. S2CID   40355653. Archived from the original (PDF) on 2007-04-04. Retrieved 2012-08-08.
  9. Soares P, Ermini L, Thomson N, Mormina M, Rito T, Röhl A, Salas A, Oppenheimer S, Macaulay V, Richards MB (2009). "Supplemental Data Correcting for Purifying Selection: An Improved Human Mitochondrial Molecular Clock". The American Journal of Human Genetics. 84 (6): 82–93. doi:10.1016/j.ajhg.2009.05.001. PMC   2694979 . PMID   19500773.
  10. Luísa Pereira; Viktor Černý; María Cerezo; Nuno M Silva; Martin Hájek; Alžběta Vašíková; Martina Kujanová; Radim Brdička; Antonio Salas (17 March 2010). "Linking the sub-Saharan and West Eurasian gene pools: maternal and paternal heritage of the Tuareg nomads from the African Sahel". European Journal of Human Genetics. 18 (8): 915–923. doi:10.1038/ejhg.2010.21. PMC   2987384 . PMID   20234393.
  11. S. Plaza; F. Calafell; A. Helal; N. Bouzerna; G. Lefranc; J. Bertranpetit; D. Comas (July 2003). "Joining the Pillars of Hercules: mtDNA Sequences Show Multidirectional Gene Flow in the Western Mediterranean". Annals of Human Genetics. 67 (4): 312–328. doi:10.1046/j.1469-1809.2003.00039.x. PMID   12914566. S2CID   11201992.
  12. Fadhlaoui-Zid K, Plaza S, Calafell F, Ben Amor M, Comas D, Bennamar El gaaied A (May 2004). "Mitochondrial DNA heterogeneity in Tunisian Berbers". Annals of Human Genetics. 68 (Pt 3): 222–33. doi:10.1046/j.1529-8817.2004.00096.x. PMID   15180702. S2CID   6407058.
  13. Asmahan Bekada; Lara R. Arauna; Tahria Deba; Francesc Calafell; Soraya Benhamamouch; David Comas (September 24, 2015). "Genetic Heterogeneity in Algerian Human Populations". PLOS ONE. 10 (9): e0138453. Bibcode:2015PLoSO..1038453B. doi: 10.1371/journal.pone.0138453 . PMC   4581715 . PMID   26402429.; S5 Table
  14. W. Haak et al., Ancient DNA from the First European Farmers in 7500-Year-Old Neolithic Sites, Science, vol. 310, no. 5750 (2005), pp. 1016-1018.
  15. W. Haak, et al., Ancient DNA from European Early Neolithic Farmers Reveals Their Near Eastern Affinities, PLOS Biology, vol. 8, no.11 (November 2010), e1000536.
  16. A. V. Nedoluzhko, E. S. Boulygina, A. S. Sokolov, S. V. Tsygankova, N. M. Gruzdeva, A. D. Rezepkin, E. B. Prokhortchouk. Analysis of the Mitochondrial Genome of a Novosvobodnaya Culture Representative using Next-Generation Sequencing and Its Relation to the Funnel Beaker Culture
  17. A. G. Nikitin et al. (2010) Comprehensive site chronology and ancient Mitochondrial DNA analysis from Verteba cave – a trypillian culture site of eneolithic Ukraine
  18. Unetice Culture (c. 2300-1600 BCE)
  19. Bernard Secher; Rosa Fregel; José M Larruga; Vicente M Cabrera; Phillip Endicott; José J Pestano; Ana M González (2014). "The history of the North African mitochondrial DNA haplogroup U6 gene flow into the African, Eurasian and American continents". BMC Evolutionary Biology. 14 (1): 109. Bibcode:2014BMCEE..14..109S. doi: 10.1186/1471-2148-14-109 . PMC   4062890 . PMID   24885141.
  20. GenBank Accession number:  MN516627.1
  21. GenBank Accession number:  MF077563.1
  22. Brook, Kevin Alan (2022). The Maternal Genetic Lineages of Ashkenazic Jews. Academic Studies Press. pp. 118–119. doi:10.2307/j.ctv33mgbcn. ISBN   978-1644699843. S2CID   254519342.
  23. Brook, Kevin Alan (2022). The Maternal Genetic Lineages of Ashkenazic Jews. Academic Studies Press. p. 119. doi:10.2307/j.ctv33mgbcn. ISBN   978-1644699843. S2CID   254519342.
  24. GenBank Accession number:  KF964063.1
  25. GenBank Accession number:  KX868658.1
  26. GenBank Accession number:  MK036913.1
  27. GenBank Accession number:  JX153279.1
  28. "PhyloTree.org | tree | R0".
  29. Brook, Kevin Alan (2022). The Maternal Genetic Lineages of Ashkenazic Jews. Academic Studies Press. pp. 120–121. doi:10.2307/j.ctv33mgbcn. ISBN   978-1644699843. S2CID   254519342.
  30. GenBank Accession number:  OL875073.1
  31. http://www.ianlogan.co.uk/sequences_by_group/v29-v33_genbank_sequences.htm [ bare URL ]
  32. http://www.ianlogan.co.uk/sequences_by_group/v29-v33_genbank_sequences.htm [ bare URL ]
  33. http://www.ianlogan.co.uk/sequences_by_group/v29-v33_genbank_sequences.htm [ bare URL ]
  34. http://www.ianlogan.co.uk/sequences_by_group/v29-v33_genbank_sequences.htm [ bare URL ]
  35. http://www.ianlogan.co.uk/sequences_by_group/v29-v33_genbank_sequences.htm [ bare URL ]
  36. Gates Jr., Henry Louis (2015). Finding Your Roots: The Official Companion to the PBS Series. The University of North Carolina Press. p. 110.
  37. Gates Jr., Henry Louis (2015). Finding Your Roots: The Official Companion to the PBS Series. The University of North Carolina Press. p. 110.