Haplogroup Z

Last updated
Haplogroup Z
Possible time of origin21,661.6 [95% CI 13,280.8 <-> 30,042.4] ybp [1]

24,900 [95% CI 15,900 <-> 34,400] ybp [2]

25,300 (95% CI 20,300 <-> 31,200) ybp [3]
Possible place of originCentral Asia
Ancestor CZ
Defining mutations152 6752 9090 15784 16185 16260 [4]

In human mitochondrial genetics, Haplogroup Z is a human mitochondrial DNA (mtDNA) haplogroup.

Contents

Frequency distribution of mtDNA haplogroup Z in Eurasia Eurasian frequency distribution of mtDNA haplogroup Z.png
Frequency distribution of mtDNA haplogroup Z in Eurasia

Origin

Haplogroup Z is believed to have arisen in Central Asia, and is a descendant of haplogroup CZ.

Distribution

The greatest clade diversity of haplogroup Z is found in East Asia and Central Asia. However, its greatest frequency appears in some peoples of Russia, such as Evens from Kamchatka (8/39 Z1a2a, 3/39 Z1a3, 11/39 = 28.2% Z total) and from Berezovka, Srednekolymsky District, Sakha Republic (3/15 Z1a3, 1/15 Z1a2a, 4/15 = 26.7% Z total), and among the Saami people of northern Scandinavia. With the exception of three Khakasses who belong to Z4, [5] two Yakut who belong to Z3a1, [5] two Yakut, a Yakutian Evenk, a Buryat, and an Altai Kizhi who belong to Z3(xZ3a, Z3c), [5] and the presence of the Z3c clade among populations of Altai Republic, [5] nearly all members of haplogroup Z in North Asia and Europe belong to subclades of Z1. The TMRCA of Z1 is 20,400 [95% CI 7,400 <-> 34,000] ybp according to Sukernik et al. 2012, [2] 20,400 [95% CI 7,800 <-> 33,800] ybp according to Fedorova et al. 2013, [5] or 19,600 [95% CI 12,500 <-> 29,300] ybp according to YFull. [3] Among the members (Z1, Z2, Z3, Z4, and Z7) of haplogroup Z, Nepalese populations were characterized by rare clades Z3a1a and Z7, of which Z3a1a was the most frequent sub-clade in Newar, with a frequency of 16.5%. [6] Z3, found in East Asia, North Asia, and MSEA, is the oldest member of haplogroup Z with an estimated age of ~ 25.4 Kya. [6] Haplogroup Z3a1a is also detected in other Nepalese populations, such as Magar (5.4%), Tharu, Kathmandu (mixed population) and Nepali-other (mixed population from Kathmandu and Eastern Nepal). [6] S6). Z3a1a1 detected in Tibet, Myanmar, Nepal, India, Thai-Laos and Vietnam trace their ancestral roots to China with a coalescent age of ~ 8.4 Kya [6]

Fedorova et al. 2013 have reported finding Z* (xZ1a, Z3, Z4) in 1/388 Turks and 1/491 Kazakhs. These individuals should belong to Z1* (elsewhere observed in a Tofalar), Z2 (observed in Japanese), Z7 (observed in the Himalaya), Z5 (observed in Japanese), or basal Z* (observed in a Blang individual in Northern Thailand). [5]

Subclades

Tree

This phylogenetic tree of haplogroup Z subclades is based on the paper by Mannis van Oven and Manfred Kayser Updated comprehensive phylogenetic tree of global human mitochondrial DNA variation [4] and subsequent published research.

See also

Phylogenetic tree of human mitochondrial DNA (mtDNA) haplogroups

  Mitochondrial Eve (L)  
L0 L1–6 
L1 L2   L3    L4 L5 L6
M N  
CZ D E G Q   O A S R   I W X Y
C Z B F R0   pre-JT   P   U
HV JT K
H V J T

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