Haplogroup F (mtDNA)

Last updated
Haplogroup F
Peopling of eurasia.jpg
Possible time of origin43,400 YBP [1]
Possible place of origin Asia
Ancestor R9
DescendantsF1, F2, F3, F4
Defining mutations249d, 6392, 10310 [2]

Haplogroup F is a human mitochondrial DNA (mtDNA) haplogroup. The clade is most common in East Asia and Southeast Asia. It has not been found among Native Americans. [3]

Contents

It is a primary branch of haplogroup R9.

Distribution

The F haplogroup is fairly common in East Asia. High frequencies of the clade are found among the Lahu from Yunnan (33% - 77%, average 52%), Nicobar Islands (50%), Shors from Kemerovo Oblast of Siberia (41%), and Arunachal Pradesh, India (31%). [4] There is also an important frequency in Taiwanese aborigines, Khakas, Kets, Han Chinese (and, thus, nearly all of China), Lombok, Sumba, Thailand, and Vietnam. Its distribution extends with low frequency to the Tharu of southern Nepal and the Bashkirs of the southern Urals. [5] [6] [7]

Haplogroup F also occurs at low frequencies on the Comoros Islands (<10%). [8] It is also found at low frequencies on The Hvar island in Croatia (8.3%).

Subclades

F1a clearly predominates among the representatives of haplogroup F in Southeast Asia, but subclades of this haplogroup have been found in populations as far north as the Buryats and Ulchi of Siberia.

F1b tends to become more frequent as a fraction of total F in populations of the northern parts of East Asia and Central Asia, such as Mongols, Kazakhs, Uyghurs, and Japanese. It also has been found among the Yi people. There are odd exclaves of F1b in Gaininsk Bashkirs of Perm Oblast and Croats of Hvar Island. [5] [9]

F1d is the second most frequent sub-clade in Newar (Nepal). Haplogroup F1d reaches the greatest proportion in Newar (11.97%) of Nepal and Kshatriya (16%) of North India. [10]

F2 has been found mainly in the form of F2a, which has been observed in more than 10% of a couple samples of Nu and Lisu from Gongshan, Yunnan. [11] F2 has been found with frequencies exceeding 5% in several other populations of Southwest China, Guangxi, and Hainan, including the Han majority population. Outside of southwestern China, F2 has been found with frequency greater than 5% in a sample of Oirat Mongols from Xinjiang and a sample of Khakas from Khakassia, with the former population boasting particularly high diversity within this clade.

F3 is especially common among Austronesian peoples of Taiwan and the Malay Archipelago, but it also has been found in many populations of Southwest China and South-Central China, and in a sample of Hans from Xinjiang.

F4 has been found mainly in aboriginal populations of Taiwan and Hainan, with some representatives among samples of Filipinos from Luzon, Indonesians from Sumatra, and Hans and Uzbeks from Xinjiang.

Tree

This phylogenetic tree of haplogroup F subclades is based on the paper by Mannis van Oven and Manfred Kayser Updated comprehensive phylogenetic tree of global human mitochondrial DNA variation [2] and subsequent published research.

Table of frequencies by ethnic group

PopulationFrequencyCountSourceSubtypes
Lahu (Lancang, Yunnan)0.77135 [11] F1a=18, F(xF1a, F1b, F1c, F2a)=9
Senoi (Malaysia)0.44252 [19] F1a1a=23
Tujia (Yongshun, Hunan)0.43330 [11] F(xF1a, F1b, F1c, F2a)=6, F1a=4, F1c=2, F1b=1
Shor (Kemerovo)0.41582 [4] F1=33, F2a=1
Lahu (Simao, Yunnan)0.34432 [11] F1a=10, F2a=1
Lahu (Xishuangbanna, Yunnan)0.33315 [11] F1a=3, F1b=1, F1c=1
Pan Yao (Tianlin, Guangxi)0.31332 [20] F3=2, F1b=2, F1a1a=2, F1a1(xF1a1a)=2, F1a(xF1a1)=1, F1c=1
Yi (Hezhang County, Guizhou)0.30020[ citation needed ]F1b=4, F1a=2
Lingao (Hainan)0.29031[ citation needed ]F(xF1, F2, F3, F4)=2, F2=2, F1(xF1a)=1, F1a1(xF1a1a)=1, F1a1a=1, F3=1, F4=1
Lowland Yao (Fuchuan, Guangxi)0.28642 [20] F2a=4, F1a1(xF1a1a)=2, F1a(xF1a1)=2, F1b=1, F1c=1, F1(xF1a, F1b, F1c)=1, F3=1
Xiban Yao (Fangcheng, Guangxi)0.27311 [20] F1b=1, F1a(xF1a1)=1, F(xF1, F2a, F3)=1
Lanten Yao (Tianlin, Guangxi)0.26926 [20] F1a(xF1a1)=5, F1a1(xF1a1a)=1, F(xF1, F2a, F3)=1
Bai (Xishuangbanna, Yunnan)0.26319 [11] F1a=2, F1b=2, F(xF1a, F1b, F1c, F2a)=1
Huatou Yao (Fangcheng, Guangxi)0.26319 [20] F1a1a=2, F1a1(xF1a1a)=1, F1a(xF1a1)=1, F(xF1, F2a, F3)=1
Vietnamese0.26242[ citation needed ]F1a=10, F(xF1a, F1b, F1c, F2)=1
Taiwan (aborigines) 0.253640[ citation needed ]F4=72, F3=54, F1a1(xF1a1a)=21, F1a(xF1a1)=14, F2=1
Bai (Dali, Yunnan)0.25068 [11] F1a=6, F1c=4, F2a=4, F1b=2, F(xF1a, F1b, F1c, F2a)=1
Indonesian (Mataram, Lombok)0.25044 [19] F1a1a=4, F1a(xF1a1, F1a3, F1a4, F1a5)=4, F1a3=1, F1a4=1, F(xF1a, F1b, F2, F3a, F3b, F4)=1
Uyghur (Uzbekistan/Kyrgyzstan)0.25016 [21] F=4
Yi (Xishuangbanna, Yunnan)0.25016 [11] F1b=2, F1a=1, F2a=1
Khakassian (Khakassia)0.24657 [4] F1=11, F2a=3
Naxi (Lijiang, Yunnan)0.24445 [11] F1a=8, F1b=2, F2a=1
Bunu (Dahua & Tianlin, Guangxi)0.24025 [20] F1b=2, F(xF1, F2a, F3)=1, F1a1(xF1a1a)=1, F1a1a=1, F3=1
Ket 0.23738 [22] F=9
Han (Beijing)0.22540[ citation needed ]F1a=4, F(xF1a, F1b, F1c, F2)=3, F1b=2
Taiwanese (Taipei, Taiwan)0.22091[ citation needed ]F=20
Han (Southwest China; pool of 44 Sichuan, 34 Chongqing, 33 Yunnan, & 26 Guizhou)0.219137[ citation needed ]F1a=15, F2=8, F3=7
Hani (Xishuangbanna, Yunnan)0.21233 [11] F1a=6, F1b=1
Tibetan (Shigatse, Tibet)0.20729[ citation needed ]F1a=5, F1b=1
Tujia (Yanhe County, Guizhou)0.20729[ citation needed ]F1a=2, F1c=1, F2a3=1, F2b=1, F(xF1, F2)=1
Bapai Yao (Liannan, Guangdong)0.20035 [20] F1b=3, F3=2, F1a1a=1, F1a(xF1a1)=1
Indonesian (Waingapu, Sumba)0.20050 [19] F1a4=3, F1a3=2, F1a1a=2, F1a(xF1a1, F1a3, F1a4, F1a5)=1, F1a1(xF1a1a)=1, F3b=1
Manchurian 0.20040[ citation needed ]F(xF1a, F1b, F1c, F2)=3, F1a=2, F1b=2, F1c=1
Thai 0.20040[ citation needed ]F1b=8
Li (Hainan)0.197346[ citation needed ]F1a1(xF1a1a)=30, F2=20, F1(xF1a)=4, F1a(xF1a1)=4, F1a1a=3, F3=3, F4=3, F(xF1, F2, F3, F4)=1
Han (Xinjiang)0.19147[ citation needed ]F1a=2, F3=2, F1b=1, F1c=1, F2a2=1, F2a3=1, F4=1
Thailand 0.190105 [23] F1=18, F(xF1)=2
Lisu (Gongshan, Yunnan)0.18937 [11] F2a=4, F1b=2, F1a=1
Han (southern California)0.187390[ citation needed ]F=73
Oirat Mongol (Xinjiang)0.18449[ citation needed ]F2(xF2a2, F2a3, F2b)=3, F1b=3, F1a=2, F2b=1
Dong (Tianzhu County, Guizhou)0.17928[ citation needed ]F1a=4, F1b=1
Han (Taiwan)0.1751117[ citation needed ]F=196
CHB (Han from Beijing Normal University)0.174121[ citation needed ]F=21
Jino (Xishuangbanna, Yunnan)0.16718 [11] F1a=2, F1b=1
Nu (Gongshan, Yunnan)0.16730 [11] F2a=5
Gelao (Daozhen County, Guizhou)0.16131[ citation needed ]F1a=3, F1(xF1a, F1b, F1c)=1, F(xF1, F2)=1
Nepal (Newar)0.155 [10] F1c1a = 2.4%, F1d = 12%, F1g = 2.4%, F2b1 = 1.1%
CHD (Han from Denver)0.15173[ citation needed ]F=11
Filipino (Palawan)0.15020[ citation needed ]F3b2=3
Indonesian (52 Pekanbaru, 42 Medan, 34 Bangka, 28 Palembang, & 24 Padang)0.150180 [19] F1a1a=9, F1a(xF1a1, F1a3, F1a4, F1a5)=8, F1a5=3, F4=3, F1a3=2, F1a4=2
Kyrgyz (Uzbekistan/Kyrgyzstan)0.15020 [21] F=3
Yi (Shuangbai, Yunnan)0.15040 [11] F(xF1a, F1b, F1c, F2a)=2, F1a=2, F1b=2
Mongolian (Ulan Bator)0.14947[ citation needed ]F1a=3, F1b=3, F2a=1
Borneo (89 Banjarmasin & 68 Kota Kinabalu)0.146157 [19] F3b=9, F(xF1a, F1b, F2, F3a, F3b, F4)=4, F1a3=3, F1a4=3, F1a1(xF1a1a)=2, F1a(xF1a1, F1a3, F1a4, F1a5)=1, F1a1a=1
Indonesian (Bali)0.14682 [19] F1a(xF1a1, F1a3, F1a4, F1a5)=5, F1a1(xF1a1a)=4, F1a1a=2, F(xF1a, F1b, F2, F3a, F3b, F4)=1
Hmong (Jishou, Hunan)0.146103 [20] F1a1(xF1a1a)=4, F1a1a=3, F(xF1, F2a, F3)=3, F1a(xF1a1)=2, F1b=2, F3=1
Aini (Xishuangbanna, Yunnan)0.14050 [11] F1a=6, F(xF1a, F1b, F1c, F2a)=1
Indonesian (Ambon)0.14043 [19] F1a3=3, F1a4=2, F1a1a=1
Cun (Hainan)0.13330[ citation needed ]F4=3, F1a1(xF1a1a)=1
Hui (Xinjiang)0.13345[ citation needed ]F1b=2, F1c=2, F1a=1, F2a3=1
Batak (Palawan)0.12931[ citation needed ]F1a3=3, F3b2=1
Yi (Luxi, Yunnan)0.12931 [11] F1b=3, F(xF1a, F1b, F1c, F2a)=1
Mongolian (Khovd Province)0.128429 [14] F(xF1e1a)=7, F1=3, F1a=2, F1a1=4, F1a1a(xF1a1a1)=4, F1a2=2, F1b=2, F1b1(xF1b1b)=5, F2=1, F2a=14, F2b1=4, F4a=7
Guoshan Yao (Jianghua, Hunan)0.12524 [20] F1a(xF1a1)=1, F1b=1, F3=1
Tu Yao (Hezhou, Guangxi)0.12241 [20] F1a1a=4, F1a(xF1a1)=1
Gelao (Daozhen County, Guizhou)0.118102[ citation needed ]F1a(xF1a1)=4, F1b=3, F2(xF2a, F2b)=2, F3a=2, F3(xF3a)=1
Tibetan (Nagchu, Tibet)0.11435[ citation needed ]F=4
Tibetan (Lhasa, Tibet)0.11444[ citation needed ]F1a=2, F2=2, F1b=1
Filipino (Luzon)0.113177 [24] F1a3=6, F1a4=6, F3b=5, F4b=2, F1a1a=1
Indonesian (Alor)0.11145 [19] F1a4=3, F1a1a=1, F1a(xF1a1, F1a3, F1a4, F1a5)=1
Indonesian (Sulawesi, incl. 89 Manado, 64 Toraja, 46 Ujung Padang, & 38 Palu)0.110237 [19] F1a4=12, F1a3=4, F1a(xF1a1, F1a3, F1a4, F1a5)=4, F1a1a=3, F1a1(xF1a1a)=1, F1a5=1, F1b=1
Tujia (western Hunan)0.10964 [11] F(xF1a, F1b, F1c, F2a)=2, F1a=2, F1b=2, F1c=1
Cham (Bình Thuận, Vietnam)0.107168 [25] F1a1a=10, F1(xF1a)=3, F1a(xF1a1)=3, F1a1(xF1a1a)=2
Tibetan (Shannan, Tibet)0.10519[ citation needed ]F=2
Altai Kizhi (Altai Republic)0.102324 [26] F1=25, F2=8
Dingban Yao (Mengla, Yunnan)0.10010 [20] F1a(xF1a1)=1
Filipino (Visayas)0.098112 [24] F1a4=7, F1a3=3, F3b=1
Korean (South Korea)0.097185[ citation needed ]F1a=8, F1b=8, F2(xF2a)=2
Korean (Seoul National University Hospital)0.0971365 [27] F=132
Filipino 0.09464 [24] F1a3=3, F1a4=3
Mien (Shangsi, Guangxi)0.09432 [20] F1a1(xF1a1a)=2, F1a1a=1
Tibetan (Tibet)0.093216[ citation needed ]F1a=13, F1b=4, F2=3
Mongolian (Mongolia)0.0922420 [14] F1a=55, F1b=71, F1c=13, F1(xF1d, F1e1)=33, F2=44, F3a=2, F4a=7
CHS (Han from Hunan & Fujian)0.09155[ citation needed ]F=5
Altai ( Altai Republic)0.091110 [28] F=10
Mongolian (Khentii Province)0.091132 [14] F1=1, F1a=3, F1b=5, F1c=2, F2b=1
Buryat 0.087126[ citation needed ]F1b=6, F1a=3, F(xF1a, F1b, F1c, F2a)=2
Tofalar 0.08746 [22] F1b=4
Uzbek (Xinjiang)0.08658[ citation needed ]F2a3=2, F4=2, F1b=1
Tuvinian (Tuva)0.086105 [4] F1=8, F2a=1
Korean (South Korea)0.083850 [29] F1a(xF1a3)=7, F1a1=17, F1b1=19, F1(xF1c, F1d)=11, F2=14, F3a=2, F4a1a=1
Japanese (Tōhoku)0.083336[ citation needed ]F=28
Mongol (New Barag Left Banner)0.08348[ citation needed ]F1a=2, F1c=1, F2a=1
Pumi (Ninglang, Yunnan)0.08336 [11] F2a=2, F1b=1
Tibetan (Diqing, Yunnan)0.08324 [11] F1a=1, F1b=1
Korean (South Korea)0.080593 [30] F=3, F1=7, F1ac=2, F1a=12, F1c=2, F1b=16, F2a=3
Korean (Ulsan)0.0791094 [31] F=86
Korean (northern China)0.07851[ citation needed ]F(xF1a, F1b, F1c, F2)=1, F1a=1, F1b=1, F1c=1
Daur (Hulunbuir)0.076209 [32] F1a=2, F1a1(xF1a1a)=4, F1a1a1=1, F1b1(xF1b1b)=2, F1c1a=1, F2(xF2d)=5, F4a1b=1
JPT (Japanese from Tokyo)0.076118[ citation needed ]F=9
Kazakh (Xinjiang)0.07553[ citation needed ]F1b=3, F2(xF2a2, F2a3, F2b)=1
Chinese (Shenyang, Liaoning)0.075160[ citation needed ]F=12
Danga (Hainan)0.07540[ citation needed ]F1a1(xF1a1a)=1, F2=1, F3=1
Japanese (northern Kyūshū)0.074256[ citation needed ]F=19
Tibetan (Nyingchi, Tibet)0.07454[ citation needed ]F1a=2, F1b=2
Mongolian (Sükhbaatar Province)0.073246 [14] F=1, F1a=5, F1b=8, F1c=3, F2i=1
Uyghur 0.07355[ citation needed ]F1b=2, F1a=1, F1c=1
Filipino (Mindanao)0.07170 [24] F3b=2, F1a4=2, F1a3=1
Korean (Seoul & Daejeon, South Korea)0.069261[ citation needed ]F1=12, F(xF1)=6
Tibetan (Chamdo, Tibet)0.06929[ citation needed ]F1a=2
Semelai (Malaysia)0.06661 [19] F1a1a=4
Japanese (Hokkaidō)0.065217 Asari 2007 F=14
Mongolian (Dornod Province)0.065370 [14] F1(xF1c, F1d)=6, F1a=7, F1b=7, F2=4
Wuzhou Yao (Fuchuan, Guangxi)0.06531 [20] F1a1(xF1a1a)=1, F3=1
Korean (South Korea)0.064203[ citation needed ]F=13
Mongolian (Ulan Bator)0.06447 [4] F1=3
Uyghur (Xinjiang)0.06447[ citation needed ]F1b=2, F1a=1
Bashkir (Beloretsky, Sterlibashevsky, Ilishevsky, & Perm)0.063221 [5] F=14
Dungan (Uzbekistan/Kyrgyzstan)0.06316 [21] F=1
Japanese (Miyazaki)0.060100 [33] F1b=3, F1a=2, F2a=1
Kazakh ( Zhetysu)0.060200 [34] F1=11, F2=1
Tharu (Chitwan, Nepal)0.060133 [6] F1c=7, F1(xF1c, F1d)=1
Japanese (Gifu)0.0591617 [35] F=96
Japanese (Tōkai)0.057282[ citation needed ]F=16
Teleut (Kemerovo)0.05753 [4] F1=3
Altai Kizhi 0.05690 [4] F1=3, F2a=2
Kalmyk (Kalmykia)0.055110 [4] F1=6
Tibetan (Shannan, Tibet)0.05555[ citation needed ]F1a=2, F2=1
Tibetan (Qinghai)0.05456 [11] F1c=2, F1a=1
Japanese 0.052211 [36] F1b=9, F1a=2
Hmong (Wenshan, Yunnan)0.05139 [20] F1b=1, F3=1
Kazakh (Kosh-Agach, Altai Republic)0.05198 [37] F1=5
Karakalpak (Uzbekistan/Kyrgyzstan)0.05020 [21] F=1
Tharu (Morang, Nepal)0.05040 [6] F1c=1, F1d=1
Turkmen (Uzbekistan/Kyrgyzstan)0.05020 [21] F=1
Korean (South Korea)0.049103 [4] F1=5
Oroqen (Oroqen Autonomous Banner)0.04544[ citation needed ]F1b=2
Yakut 0.043117[ citation needed ]F2a=3, F1b=2
Tuvan 0.04295 [22] F(xF1b)=3, F1b=1
Kyrgyz (Talas)0.04248[ citation needed ]F1a=1, F1b=1
Tibetan (Nyingchi, Tibet)0.04224[ citation needed ]F=1
Khamnigan (Buryatia)0.04099 [4] F1=4
Iu Mien (Mengla, Yunnan)0.03727 [20] F(xF1, F2a, F3)=1
Kazakh 0.03655[ citation needed ]F1b=2
Barghut (Hulunbuir)0.034149 [37] F1=4, F2=1
Buryat (Buryatia)0.031295 [4] F1=7, F2a=2
Ulch people 0.031160[ citation needed ]F1a=5
Tibetan (Zhongdian, Yunnan)0.02935 [11] F2a=1
Kim Mun (Malipo, Yunnan)0.02540 [20] F1a1(xF1a1a)=1
Uzbek (Uzbekistan/Kyrgyzstan)0.02540 [21] F=1
Okinawa 0.025326[ citation needed ]F=8
Evenk (New Barag Left Banner)0.02147[ citation needed ]F1c=1
Ainu 0.02051[ citation needed ]F1b=1
Evenk (53 Stony Tunguska basin & 18 Tugur-Chumikan)0.01471 [22] F1b=1
Telenghit (Altai Republic)0.01471 [4] F1=1
Tubalar 0.01472 [22] F1b=1
Evenk (Krasnoyarsk)0.01473 [4] F1=1
Ulchi (Old & New Bulava, Ulchsky, Khabarovsk)0.01187 [22] F(xF1b)=1
Mansi 0.01098 [22] F=1
Khanty 0.009106 [7] F1=1
Chukchi (Anadyr)0.00015 [4] -
Bukharan Arab (Uzbekistan/Kyrgyzstan)0.00020 [21] -
Crimean Tatar (Uzbekistan/Kyrgyzstan)0.00020 [21] -
Iranian (Uzbekistan/Kyrgyzstan)0.00020 [21] -
Kazakh (Uzbekistan/Kyrgyzstan)0.00020 [21] -
Tajik (Uzbekistan/Kyrgyzstan)0.00020 [21] -
Hindu (Chitwan, Nepal)0.00024 [6] -
Nganasan 0.00024 [22] -
Buryat (Kushun, Nizhneudinsk, Irkutsk Oblast)0.00025 [22] -
Kurd (northwestern Iran)0.00025 [4] -
Andhra Pradesh (tribal)0.00029 [6] -
Batek (Malaysia)0.00029 [19] -
Mendriq (Malaysia)0.00032 [19] -
Negidal 0.00033 [22] -
Temuan (Malaysia)0.00033 [19] -
Yakut (Yakutia)0.00036 [4] -
Tibetan (Deqin, Yunnan)0.00040 [11] -
Tajik (Tajikistan)0.00044 [4] -
Daur (Evenk Autonomous Banner)0.00045[ citation needed ]-
Evenk (Buryatia)0.00045 [4] -
Udege (Gvasiugi, Imeni Lazo, Khabarovsk)0.00046 [22] -
Itelmen 0.00047 [22] -
Kyrgyz (Sary-Tash)0.00047[ citation needed ]-
Korean (Arun Banner)0.00048[ citation needed ]-
Jahai (Malaysia)0.00051 [19] -
Nivkh (northern Sakhalin)0.00056 [22] -
Mansi 0.00063 [7] -
Chukchi 0.00066[ citation needed ]-
Siberian Eskimo 0.00079 [22] -
Persian (eastern Iran)0.00082 [4] -
Koryak 0.000155 [22] -

See also

Related Research Articles

<span class="mw-page-title-main">Haplogroup M (mtDNA)</span> Widespread human mitochondrial DNA grouping indicating common ancestry

Haplogroup M is a human mitochondrial DNA (mtDNA) haplogroup. An enormous haplogroup spanning all the continents, the macro-haplogroup M, like its sibling the macro-haplogroup N, is a descendant of the haplogroup L3.

<span class="mw-page-title-main">Haplogroup R (mtDNA)</span> Human mitochondrial DNA haplogroup

Haplogroup R is a widely distributed human mitochondrial DNA (mtDNA) haplogroup. Haplogroup R is associated with the peopling of Eurasia after about 70,000 years ago, and is distributed in modern populations throughout the world outside of sub-Saharan Africa.

<span class="mw-page-title-main">Haplogroup B (mtDNA)</span>

In human mitochondrial genetics, haplogroup B is a human mitochondrial DNA (mtDNA) haplogroup.

<span class="mw-page-title-main">Haplogroup N (mtDNA)</span> Widespread human mitochondrial DNA grouping indicating common ancestry

Haplogroup N is a human mitochondrial DNA (mtDNA) clade. A macrohaplogroup, its descendant lineages are distributed across many continents. Like its sibling macrohaplogroup M, macrohaplogroup N is a descendant of the haplogroup L3.

<span class="mw-page-title-main">Haplogroup A (mtDNA)</span> Human mitochondrial DNA grouping indicating common ancestry

In human mitochondrial genetics, Haplogroup A is a human mitochondrial DNA (mtDNA) haplogroup.

<span class="mw-page-title-main">Haplogroup C (mtDNA)</span>

In human mitochondrial genetics, Haplogroup C is a human mitochondrial DNA (mtDNA) haplogroup.

<span class="mw-page-title-main">Haplogroup D (mtDNA)</span> Human mitochondrial DNA (mtDNA) haplogroup

In human mitochondrial genetics, Haplogroup D is a human mitochondrial DNA (mtDNA) haplogroup. It is a descendant haplogroup of haplogroup M, thought to have arisen somewhere in East Asia, between roughly 60,000 and 35,000 years ago.

In human mitochondrial genetics, Haplogroup Z is a human mitochondrial DNA (mtDNA) haplogroup.

Haplogroup D1 or D-M174 is a subclade of haplogroup D-CTS3946. This male haplogroup is found primarily in East Asia, Magar-ethnic Nepal and the Andaman Islands. It is also found regularly with lower frequency in Central Asia and Mainland Southeast Asia, and, more rarely, in Europe and the Middle East.

<span class="mw-page-title-main">Haplogroup N-M231</span> Human Y chromosome DNA grouping common in North Eurasia

Haplogroup N (M231) is a Y-chromosome DNA haplogroup defined by the presence of the single-nucleotide polymorphism (SNP) marker M231.

<span class="mw-page-title-main">Haplogroup O-M175</span> Haplogroup O. Human Y chromosome DNA grouping common in Asia.

Haplogroup O, also known as O-M175, is a human Y-chromosome DNA haplogroup. It is primarily found among populations in Southeast Asia and East Asia. It also is found in various percentages of populations of the Russian Far East, South Asia, Central Asia, Caucasus, Crimea, Ukraine, Iran, Oceania, Madagascar and the Comoros. Haplogroup O is a primary descendant of haplogroup NO-M214.

Haplogroup O-M122 is an Eastern Eurasian Y-chromosome haplogroup. The lineage ranges across Southeast Asia and East Asia, where it dominates the paternal lineages with extremely high frequencies. It is also significantly present in Central Asia, especially among the Naiman tribe of Kazakhs.

<span class="mw-page-title-main">Haplogroup Q-M242</span> Human Y chromosome DNA grouping common among Native Americans

Haplogroup Q or Q-M242 is a Y-chromosome DNA haplogroup. It has one primary subclade, Haplogroup Q1 (L232/S432), which includes numerous subclades that have been sampled and identified in males among modern populations.

In human genetics, Haplogroup O-M268, also known as O1b, is a Y-chromosome DNA haplogroup. Haplogroup O-M268 is a primary subclade of haplogroup O-F265, itself a primary descendant branch of Haplogroup O-M175.

In human genetics, Haplogroup O-M119 is a Y-chromosome DNA haplogroup. Haplogroup O-M119 is a descendant branch of haplogroup O-F265 also known as O1a, one of two extant primary subclades of Haplogroup O-M175. The same clade previously has been labeled as O-MSY2.2.

<span class="mw-page-title-main">Haplogroup C-M217</span> Human Y-chromosome DNA haplogroup

Haplogroup C-M217, also known as C2, is a Y-chromosome DNA haplogroup. It is the most frequently occurring branch of the wider Haplogroup C (M130). It is found mostly in Central Asia, Eastern Siberia and significant frequencies in parts of East Asia and Southeast Asia including some populations in the Caucasus, Middle East, South Asia, East Europe. It is found in a much more widespread areas with a low frequency of less than 2%.

<span class="mw-page-title-main">Haplogroup Y</span> Human mitochondrial DNA grouping indicating common ancestry

In human mitochondrial genetics, Haplogroup Y is a human mitochondrial DNA (mtDNA) haplogroup.

In human mitochondrial genetics, Haplogroup G is a human mitochondrial DNA (mtDNA) haplogroup.

<span class="mw-page-title-main">Haplogroup O-M117</span> Descendant branch of haplogroup O2a (formerly O3a)

Haplogroup O2a2b1a1-M117 or Haplogroup O2a2b1a1-M117 is a subclade of O2a2b1-M134 that occurs frequently in China and in neighboring countries like Bhutan, Nepal, and Korea, also found among Sino-Tibetan language speaking people.

In human mitochondrial genetics, Haplogroup M8 is a human mitochondrial DNA (mtDNA) haplogroup.

References

  1. Soares P, Ermini L, Thomson N, Mormina M, Rito T, Röhl A, et al. (June 2009). "Correcting for purifying selection: an improved human mitochondrial molecular clock". American Journal of Human Genetics. 84 (6): 740–759. doi:10.1016/j.ajhg.2009.05.001. PMC   2694979 . PMID   19500773.
  2. 1 2 van Oven M, Kayser M (February 2009). "Updated comprehensive phylogenetic tree of global human mitochondrial DNA variation". Human Mutation. 30 (2): E386–E394. doi: 10.1002/humu.20921 . PMID   18853457. S2CID   27566749.
  3. Haplogroup F.
  4. 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 Derenko M, Malyarchuk B, Grzybowski T, Denisova G, Dambueva I, Perkova M, et al. (November 2007). "Phylogeographic analysis of mitochondrial DNA in northern Asian populations". American Journal of Human Genetics. 81 (5): 1025–1041. doi:10.1086/522933. PMC   2265662 . PMID   17924343.
  5. 1 2 3 M. A. Bermisheva, K. Tambets, R. Villems, and E. K. Khusnutdinova, "Diversity of Mitochondrial DNA Haplogroups in Ethnic Populations of the Volga–Ural Region", Molecular Biology Vol. 36, No. 6, 2002, pp. 802–812. Translated from Molekulyarnaya Biologiya, Vol. 36, No. 6, 2002, pp. 990–1001.
  6. 1 2 3 4 5 Fornarino S, Pala M, Battaglia V, Maranta R, Achilli A, Modiano G, et al. (July 2009). "Mitochondrial and Y-chromosome diversity of the Tharus (Nepal): a reservoir of genetic variation". BMC Evolutionary Biology. 9 (1): 154. Bibcode:2009BMCEE...9..154F. doi: 10.1186/1471-2148-9-154 . PMC   2720951 . PMID   19573232.
  7. 1 2 3 Pimenoff VN, Comas D, Palo JU, Vershubsky G, Kozlov A, Sajantila A (October 2008). "Northwest Siberian Khanty and Mansi in the junction of West and East Eurasian gene pools as revealed by uniparental markers". European Journal of Human Genetics. 16 (10): 1254–1264. doi: 10.1038/ejhg.2008.101 . PMID   18506205. S2CID   19488203.
  8. Msaidie S, Ducourneau A, Boetsch G, Longepied G, Papa K, Allibert C, et al. (January 2011). "Genetic diversity on the Comoros Islands shows early seafaring as major determinant of human biocultural evolution in the Western Indian Ocean". European Journal of Human Genetics. 19 (1): 89–94. doi:10.1038/ejhg.2010.128. PMC   3039498 . PMID   20700146.
  9. Tolk HV, Barac L, Pericic M, Klaric IM, Janicijevic B, Campbell H, et al. (September 2001). "The evidence of mtDNA haplogroup F in a European population and its ethnohistoric implications". European Journal of Human Genetics. 9 (9): 717–723. doi: 10.1038/sj.ejhg.5200709 . PMID   11571562.
  10. 1 2 3 4 5 Basnet R, Rai N, Tamang R, Awasthi NP, Pradhan I, Parajuli P, et al. (February 2023). "The matrilineal ancestry of Nepali populations". Human Genetics. 142 (2): 167–180. doi:10.1007/s00439-022-02488-z. PMID   36242641. S2CID   252904281.
  11. 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 Wen B, Xie X, Gao S, Li H, Shi H, Song X, et al. (May 2004). "Analyses of genetic structure of Tibeto-Burman populations reveals sex-biased admixture in southern Tibeto-Burmans". American Journal of Human Genetics. 74 (5): 856–865. doi:10.1086/386292. PMC   1181980 . PMID   15042512.
  12. 1 2 3 4 5 6 7 8 Hwan Young Lee, Ji-Eun Yoo, Myung Jin Park, Ukhee Chung, Chong-Youl Kim, and Kyoung-Jin Shin, "East Asian mtDNA haplogroup determination in Koreans: Haplogroup-level coding region SNP analysis and subhaplogroup-level control region sequence analysis." Electrophoresis (2006). DOI 10.1002/elps.200600151.
  13. 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 Wibhu Kutanan, Jatupol Kampuansai, Metawee Srikummool, Daoroong Kangwanpong, Silvia Ghirotto, Andrea Brunelli, and Mark Stoneking, "Complete mitochondrial genomes of Thai and Lao populations indicate an ancient origin of Austroasiatic groups and demic diffusion in the spread of Tai–Kadai languages." Hum Genet 2016 DOI 10.1007/s00439-016-1742-y.
  14. 1 2 3 4 5 6 7 Cardinali I, Bodner M, Capodiferro MR, Amory C, Rambaldi Migliore N, Gomez EJ, et al. (2022). "Mitochondrial DNA Footprints from Western Eurasia in Modern Mongolia". Frontiers in Genetics. 12: 819337. doi: 10.3389/fgene.2021.819337 . PMC   8773455 . PMID   35069708.
  15. Rebecca S Just, Melissa K Scheible, Spence A Fast, et al., "Full mtGenome reference data: development and characterization of 588 forensic-quality haplotypes representing three U.S. populations." Forensic Sci Int Genet. 2015 Jan;14:141-55. doi: 10.1016/j.fsigen.2014.09.021. Epub 2014 Oct 5.
  16. 1 2 3 Kong, Q.P., Yao, Y.G., Sun, C., Zhu, C.L., Zhong, L., Wang, C.Y., Cai, W.W., Xu, X.M., Xu, A.L. and Zhang, Y.P., 2004. Phylogeographic analysis of mitochondrial DNA haplogroup F2 in China reveals T12338C in the initiation codon of the ND5 gene not to be pathogenic. Journal of human genetics, 49(8), p.414.
  17. 1 2 Sardana A Fedorova, Maere Reidla, Ene Metspalu, et al., "Autosomal and uniparental portraits of the native populations of Sakha (Yakutia): implications for the peopling of Northeast Eurasia." BMC Evolutionary Biology 2013, 13:127. http://www.biomedcentral.com/1471-2148/13/127
  18. 1 2 Hongbin Yao, Mengge Wang, Xing Zou, et al., "New insights into the fine-scale history of western-eastern admixture of the northwestern Chinese population in the Hexi Corridor via genome-wide genetic legacy." Mol Genet Genomics 2021 Mar 1. doi: 10.1007/s00438-021-01767-0.
  19. 1 2 3 4 5 6 7 8 9 10 11 12 13 14 Hill C, Soares P, Mormina M, Macaulay V, Meehan W, Blackburn J, et al. (December 2006). "Phylogeography and ethnogenesis of aboriginal Southeast Asians". Molecular Biology and Evolution. 23 (12): 2480–2491. doi: 10.1093/molbev/msl124 . hdl: 1885/23220 . PMID   16982817.
  20. 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 Wen B, Li H, Gao S, Mao X, Gao Y, Li F, et al. (March 2005). "Genetic structure of Hmong-Mien speaking populations in East Asia as revealed by mtDNA lineages". Molecular Biology and Evolution. 22 (3): 725–734. doi: 10.1093/molbev/msi055 . PMID   15548747.
  21. 1 2 3 4 5 6 7 8 9 10 11 Comas D, Plaza S, Wells RS, Yuldaseva N, Lao O, Calafell F, et al. (June 2004). "Admixture, migrations, and dispersals in Central Asia: evidence from maternal DNA lineages". European Journal of Human Genetics. 12 (6): 495–504. doi: 10.1038/sj.ejhg.5201160 . PMID   14872198.
  22. 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 Starikovskaya EB, Sukernik RI, Derbeneva OA, Volodko NV, Ruiz-Pesini E, Torroni A, et al. (January 2005). "Mitochondrial DNA diversity in indigenous populations of the southern extent of Siberia, and the origins of Native American haplogroups". Annals of Human Genetics. 69 (Pt 1): 67–89. doi:10.1046/j.1529-8817.2003.00127.x. PMC   3905771 . PMID   15638829.
  23. Supannee Kaewsutthi, Nopasak Phasukkijwatana, Yutthana Joyjinda et al., "Mitochondrial Haplogroup Background May Influence Southeast Asian G11778A Leber Hereditary Optic Neuropathy", Investigative Ophthalmology & Visual Science, June 2011, Vol. 52, No. 7
  24. 1 2 3 4 Tabbada KA, Trejaut J, Loo JH, Chen YM, Lin M, Mirazón-Lahr M, et al. (January 2010). "Philippine mitochondrial DNA diversity: a populated viaduct between Taiwan and Indonesia?". Molecular Biology and Evolution. 27 (1): 21–31. doi: 10.1093/molbev/msp215 . PMID   19755666.
  25. Peng MS, Quang HH, Dang KP, Trieu AV, Wang HW, Yao YG, et al. (October 2010). "Tracing the Austronesian footprint in Mainland Southeast Asia: a perspective from mitochondrial DNA". Molecular Biology and Evolution. 27 (10): 2417–2430. doi: 10.1093/molbev/msq131 . PMID   20513740.
  26. Dulik MC, Zhadanov SI, Osipova LP, Askapuli A, Gau L, Gokcumen O, et al. (February 2012). "Mitochondrial DNA Dulik_2012 Y chromosome variation provides evidence for a recent common ancestry between Native Americans and Indigenous Altaians". American Journal of Human Genetics. 90 (2): 229–46. doi:10.1016/j.ajhg.2011.12.014. PMC   3276666 . PMID   22281367.
  27. Fuku N, Park KS, Yamada Y, Nishigaki Y, Cho YM, Matsuo H, et al. (March 2007). "Mitochondrial haplogroup N9a confers resistance against type 2 diabetes in Asians". American Journal of Human Genetics. 80 (3): 407–415. doi:10.1086/512202. PMC   1821119 . PMID   17273962.
  28. D Miścicka-Sliwka, M Woźniak, I A Zakharov (2003). "Diversity of mitochondrial DNA lineages in South Siberia". Annals of Human Genetics. 67 (Pt 5): 391–411. doi:10.1046/j.1469-1809.2003.00035.x. PMID   12940914.{{cite journal}}: CS1 maint: multiple names: authors list (link)
  29. Yoo, Seong-Keun (2019). "Northeast Asian Reference Database (NARD) Imputation Server".
  30. Lee HY, Yoo J, Park MJ, Chung U, Kim C, Shin K (2006). "East Asian mtDNA haplogroup determination in Koreans: Haplogroup-level coding region SNP analysis and subhaplogroup-level control region sequence analysis". Electrophoresis. 27 (22): 4408–4418. doi:10.1002/elps.200600151. PMID   17058303.
  31. Jeon S, Bhak Y, Choi Y, Jeon Y, Kim S, Jang J, et al. (May 2020). "Korean Genome Project: 1094 Korean personal genomes with clinical information". Science Advances. 6 (22): eaaz7835. Bibcode:2020SciA....6.7835J. doi:10.1126/sciadv.aaz7835. PMC   7385432 . PMID   32766443.
  32. Chi-Zao Wang, Xue-Er Yu, Mei-Sen Shi, Hui Li & Shu-Hua Ma (2022). "Whole mitochondrial genome analysis of the Daur ethnic minority from Hulunbuir in the Inner Mongolia Autonomous Region of China". BMC Ecology and Evolution. 22 (1): 66. doi: 10.1186/s12862-022-02019-4 . PMC   9118598 . PMID   35585500.{{cite journal}}: CS1 maint: multiple names: authors list (link)
  33. Taketo U, Rinnosuke H, Kenshi S, Kazuhiko I, Kazumasa S, Kentaro K (2007). "Mitochondrial DNA Sequence Variation and Phylogenetic Analysis in Japanese Individuals from Miyazaki Prefecture". Japanese Journal of Forensic Science and Technology. 12 (1): 83–96. doi: 10.3408/jafst.12.83 .
  34. Ayken Askapuli, Miguel Vilar, Humberto Garcia-Ortiz (2022). "Kazak mitochondrial genomes provide insights into the human population history of Central Eurasia". PLOS ONE. 17 (11): e0277771. Bibcode:2022PLoSO..1777771A. doi: 10.1371/journal.pone.0277771 . PMC   9707748 . PMID   36445929.{{cite journal}}: CS1 maint: multiple names: authors list (link)
  35. Fuku N, Park KS, Yamada Y, Nishigaki Y, Cho YM, Matsuo H, et al. (March 2007). "Mitochondrial haplogroup N9a confers resistance against type 2 diabetes in Asians". American Journal of Human Genetics. 80 (3): 407–415. doi:10.1086/512202. PMC   1821119 . PMID   17273962.
  36. Maruyama S, Minaguchi K, Saitou N (August 2003). "Sequence polymorphisms of the mitochondrial DNA control region and phylogenetic analysis of mtDNA lineages in the Japanese population". International Journal of Legal Medicine. 117 (4): 218–225. doi:10.1007/s00414-003-0379-2. PMID   12845447. S2CID   1224295.
  37. 1 2 Derenko M, Malyarchuk B, Denisova G, Perkova M, Rogalla U, Grzybowski T, et al. (2012). "Complete mitochondrial DNA analysis of eastern Eurasian haplogroups rarely found in populations of northern Asia and eastern Europe". PLOS ONE. 7 (2): e32179. Bibcode:2012PLoSO...732179D. doi: 10.1371/journal.pone.0032179 . PMC   3283723 . PMID   22363811.

Sources

Phylogenetic tree of human mitochondrial DNA (mtDNA) haplogroups

  Mitochondrial Eve (L)  
L0 L1–6 
L1 L2   L3    L4 L5 L6
M N  
CZ D E G Q   O A S R   I W X Y
C Z B F R0   pre-JT   P   U
HV JT K
H V J T