| Histidinol-phosphate transaminase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
 Histidinol-phosphate transaminase homodimer, E.Coli | |||||||||
| Identifiers | |||||||||
| EC no. | 2.6.1.9 | ||||||||
| CAS no. | 9032-98-8 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
| |||||||||
Histidinol-phosphate transaminase (EC 2.6.1.9) is an enzyme that catalyzes the reversible chemical reaction
The enzyme first characterised from Neurospora crassa converts 3-(imidazol-4-yl)-2-oxopropyl phosphate to L-histidinol phosphate (a precursor to the amino acid histidine) using L-glutamic acid as the source of the amino group that is transferred. It uses pyridoxal phosphate as a cofactor and has also been found in Salmonella typhimurium . [1] [2]
This enzyme is a transferase, specifically a transaminase, which transfer nitrogenous groups. The systematic name of this enzyme class is L-histidinol-phosphate:2-oxoglutarate aminotransferase. Other names in common use include imidazolylacetolphosphate transaminase, glutamic-imidazoleacetol phosphate transaminase, histidinol phosphate aminotransferase, imidazoleacetol phosphate transaminase, L-histidinol phosphate aminotransferase, histidine:imidazoleacetol phosphate transaminase, IAP transaminase, and imidazolylacetolphosphate aminotransferase. It participates in five metabolic pathways: histidine metabolism, tyrosine metabolism, phenylalanine metabolism, phenylalanine, tyrosine and tryptophan biosynthesis, and novobiocin biosynthesis. [3]
