Hydroxylamine dehydrogenase

Hydroxylamine dehydrogenase
Identifiers
EC no.	1.7.2.6
CAS no.	9075-43-8
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Search PMC articles PubMed articles NCBI proteins

Hydroxylamine dehydrogenase (EC 1.7.2.6, HAO (ambiguous)) is an enzyme with systematic name hydroxylamine:ferricytochrome-c oxidoreductase. ^{[1] [2] [3] [4] [5]} This enzyme catalyses the following chemical reaction

(1) hydroxylamine + H₂O + 2 ferricytochrome c ${\displaystyle \rightleftharpoons }$ nitrite + 2 ferrocytochrome c + 5 H⁺

(2) hydroxylamine + ferricytochrome c ${\displaystyle \rightleftharpoons }$ nitric oxide + ferrocytochrome c + 3 H⁺

The enzymes from the nitrifying bacterium Nitrosomonas europaea and the methylotrophic bacterium Methylococcus capsulatus are hemoproteins.

References

1. Rees MK (January 1968). "Studies of the hydroxylamine metabolism of Nitrosomonas europaea. I. Purification of hydroxylamine oxidase". Biochemistry. 7 (1): 353–66. doi:10.1021/bi00841a045. PMID   5758552.
2. Hooper AB, Terry KR (November 1979). "Hydroxylamine oxidoreductase of Nitrosomonas. Production of nitric oxide from hydroxylamine". Biochimica et Biophysica Acta. 571 (1): 12–20. doi:10.1016/0005-2744(79)90220-1. PMID   497235.
3. Hooper AB, Balny C (August 1982). "Reaction of oxygen with hydroxylamine oxidoreductase of Nitrosomonas: fast kinetics". FEBS Letters. 144 (2): 299–303. Bibcode:1982FEBSL.144..299H. doi: 10.1016/0014-5793(82)80658-3 . PMID   7117545. S2CID   9726167.
4. Lipscomb JD, Hooper AB (August 1982). "Resolution of multiple heme centers of hydroxylamine oxidoreductase from Nitrosomonas. 1. Electron paramagnetic resonance spectroscopy". Biochemistry. 21 (17): 3965–72. doi:10.1021/bi00260a010. PMID   6289867.
5. Poret-Peterson AT, Graham JE, Gulledge J, Klotz MG (December 2008). "Transcription of nitrification genes by the methane-oxidizing bacterium, Methylococcus capsulatus strain Bath". The ISME Journal. 2 (12): 1213–20. Bibcode:2008ISMEJ...2.1213P. doi: 10.1038/ismej.2008.71 . PMID   18650926.

External links

• Hydroxylamine+dehydrogenase at the U.S. National Library of Medicine Medical Subject Headings (MeSH)