Canine mastadenovirus A | |
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Virus classification | |
(unranked): | Virus |
Realm: | Varidnaviria |
Kingdom: | Bamfordvirae |
Phylum: | Preplasmiviricota |
Class: | Tectiliviricetes |
Order: | Rowavirales |
Family: | Adenoviridae |
Genus: | Mastadenovirus |
Species: | Canine mastadenovirus A |
Synonyms | |
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Infectious canine hepatitis (ICH) is an acute liver infection in dogs caused by Canine mastadenovirus A, formerly called Canine adenovirus 1 (CAV-1). Canine mastadenovirus A also causes disease in wolves, coyotes, and bears, and encephalitis in foxes. [1] The virus is spread in the feces, urine, blood, saliva, and nasal discharge of infected dogs. It is contracted through the mouth or nose, where it replicates in the tonsils. The virus then infects the liver and kidneys. The incubation period is 4 to 9 days. [2]
Symptoms include fever, depression, loss of appetite, coughing, and a tender abdomen. Corneal edema and signs of liver disease, such as jaundice, vomiting, and hepatic encephalopathy, may also occur. Severe cases will develop bleeding disorders, which can cause hematomas to form in the mouth. [1] Death can occur secondary to this or the liver disease. However, most dogs recover after a brief illness, although chronic corneal edema and kidney lesions may persist. [3]
Diagnosis is made by recognizing the combination of symptoms and abnormal blood tests that occur in infectious canine hepatitis. A rising antibody titer to CAV-1 is also seen. The disease can be confused with canine parvovirus because both will cause a low white blood cell count and bloody diarrhea in young, unvaccinated dogs.
Treatment is symptomatic. Most dogs recover spontaneously without treatment. Prevention is through vaccination (ATCvet code QI07AA05 ( WHO ) and various combination vaccines). Most combination vaccines for dogs contain a modified canine adenovirus type-2. [4] CAV-2 is one of the causes of respiratory infections in dogs, but it is similar enough to CAV-1 that vaccine for one creates immunity for both. CAV-2 vaccine is much less likely to cause side effects than CAV-1 vaccine. [2] One study has shown the vaccine to have a duration of immunity of at least four years. [5]
CAV-1 is destroyed in the environment by steam cleaning and quaternary ammonium compounds. Otherwise, the virus can survive in the environment for months in the right conditions. It can also be released in the urine of a recovered dog for up to a year. [2]
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The health of dogs is a well studied area in veterinary medicine.
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Porcine parvovirus (PPV), a virus in the species Ungulate protoparvovirus 1 of genus Protoparvovirus in the virus family Parvoviridae, causes reproductive failure of swine characterized by embryonic and fetal infection and death, usually in the absence of outward maternal clinical signs. The disease develops mainly when seronegative dams are exposed oronasally to the virus anytime during about the first half of gestation, and conceptuses are subsequently infected transplacentally before they become immunocompetent. There is no definitive evidence that infection of swine other than during gestation is of any clinical or economic significance. The virus is ubiquitous among swine throughout the world and is enzootic in most herds that have been tested. Diagnostic surveys have indicated that PPV is the major infectious cause of embryonic and fetal death. In addition to its direct causal role in reproductive failure, PPV can potentiate the effects of porcine circovirus type II (PCV2) infection in the clinical course of postweaning multisystemic wasting syndrome (PMWS).
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