Isolated organ perfusion technique is employed to precipitate an organ's perfusion and circulation that are independent/isolated from the body's systemic circulation for various purposes such as organ-localized chemotherapy, organ-targeted delivery of drug, gene or anything else, organ transplantation, and organ injury recovery. The technique has been widely studied in animal and human for decades. [1] [2] [3] [4] [5] [6] [7] Before the implementation, the perfusion system will be selected and the process can be similar to organ bath. [8] Isolated organ perfusion technique, nevertheless, is averagely conducted in vivo without leaving the organ alone as a whole out of the body. [9]
Technological advances in artificial perfusion allow effective isolated perfusion of a wide variety of organs and tissues, including, but not limited to, brain, heart, lung, heart-lung, liver, kidney, spleen, pancreas, thymus, gastrointestinal tract, urinary tract, reproductive tract, skeletal muscle, nerves, and blood vessels.