LPCAT1

LPCAT1
Identifiers
Aliases	LPCAT1 , lysophosphatidylcholine acyltransferase 1, AYTL2, PFAAP3, lpcat, AGPAT10, AGPAT9, LPCAT-1, lysoPAFAT
External IDs	OMIM: 610472; MGI: 2384812; HomoloGene: 9871; GeneCards: LPCAT1; OMA:LPCAT1 - orthologs
EC number	2.3.1.67
Gene location (Human) Chr. Chromosome 5 (human) [1] Band 5p15.33 Start 1,456,480 bp [1] End 1,523,962 bp [1]
Gene location (Mouse) Chr. Chromosome 13 (mouse) [2] Band 13|13 C1 Start 73,615,316 bp [2] End 73,664,541 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in upper lobe of left lung spleen ventricular zone granulocyte right lung ganglionic eminence blood lymph node monocyte appendix Top expressed in left lung left lung lobe Rostral migratory stream right lung right lung lobe retinal pigment epithelium tibiofemoral joint ciliary body primary oocyte fetal liver hematopoietic progenitor cell More reference expression data BioGPS n/a
Gene ontology Molecular function 1-alkylglycerophosphocholine O-acyltransferase activity metal ion binding calcium ion binding transferase activity acyltransferase activity 1-alkylglycerophosphocholine O-acetyltransferase activity 1-alkenylglycerophosphocholine O-acyltransferase activity 1-acylglycerophosphocholine O-acyltransferase activity 1-acylglycerol-3-phosphate O-acyltransferase activity 2-acylglycerol-3-phosphate O-acyltransferase activity Cellular component integral component of membrane Golgi apparatus Golgi membrane membrane lipid droplet endoplasmic reticulum membrane endoplasmic reticulum plasma membrane azurophil granule membrane Biological process phospholipid biosynthetic process retina development in camera-type eye lipid metabolism phosphatidylglycerol acyl-chain remodeling positive regulation of protein catabolic process phosphatidic acid biosynthetic process metabolism surfactant homeostasis negative regulation of phosphatidylcholine biosynthetic process phosphatidylcholine acyl-chain remodeling phospholipid metabolic process phosphatidylcholine biosynthetic process neutrophil degranulation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 79888 210992 Ensembl ENSG00000275079 ENSG00000153395 ENSMUSG00000021608 UniProt Q8NF37 Q3TFD2 RefSeq (mRNA) NM_024830 NM_145376 NM_001368681 NM_001368682 RefSeq (protein) NP_079106 NP_663351 NP_001355610 NP_001355611 Location (UCSC) Chr 5: 1.46 – 1.52 Mb Chr 13: 73.62 – 73.66 Mb PubMed search [3] [4]
Wikidata
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Lysophosphatidylcholine acyltransferase 1 is a protein in humans that is encoded by the LPCAT1 gene. ^[5]

Lysophosphatidylcholine (LPC) acyltransferase (LPCAT; EC 2.3.1.23) catalyzes the conversion of LPC to phosphatidylcholine (PC) in the remodeling pathway of PC biosynthesis. ^[6]

References

1. ENSG00000153395 GRCh38: Ensembl release 89: ENSG00000275079, ENSG00000153395 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000021608 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: Lysophosphatidylcholine acyltransferase 1". Archived from the original on December 16, 2018.
6. Nakanishi H, Shindou H, Hishikawa D, Harayama T, Ogasawara R, Suwabe A, Taguchi R, Shimizu T (2006). "Cloning and characterization of mouse lung-type acyl-CoA:lysophosphatidylcholine acyltransferase 1 (LPCAT1). Expression in alveolar type II cells and possible involvement in surfactant production". J. Biol. Chem. 281 (29): 20140–7. doi: 10.1074/jbc.M600225200 . PMID   16704971.