LPCAT1

LPCAT1
Identifiers
Aliases	LPCAT1 , lysophosphatidylcholine acyltransferase 1, AYTL2, PFAAP3, lpcat, AGPAT10, AGPAT9, LPCAT-1, lysoPAFAT
External IDs	OMIM: 610472 MGI: 2384812 HomoloGene: 9871 GeneCards: LPCAT1
EC number	2.3.1.67
Gene location (Human)
Chr.	Chromosome 5 (human) [1]
End	1,523,962 bp [1]
Gene location (Mouse)
Chr.	Chromosome 13 (mouse) [2]
End	73,516,422 bp [2]
Gene ontology
Molecular function	• 1-alkylglycerophosphocholine O-acyltransferase activity ; • metal ion binding ; • calcium ion binding ; • transferase activity ; • transferase activity, transferring acyl groups ; • 1-alkylglycerophosphocholine O-acetyltransferase activity ; • 1-alkenylglycerophosphocholine O-acyltransferase activity ; • 1-acylglycerophosphocholine O-acyltransferase activity ; • 1-acylglycerol-3-phosphate O-acyltransferase activity ; • 2-acylglycerol-3-phosphate O-acyltransferase activity ;
Cellular component	• integral component of membrane ; • Golgi apparatus ; • Golgi membrane ; • membrane ; • lipid droplet ; • endoplasmic reticulum membrane ; • endoplasmic reticulum ; • cell membrane ; • azurophil granule membrane ;
Biological process	• phospholipid biosynthetic process ; • retina development in camera-type eye ; • lipid metabolism ; • phosphatidylglycerol acyl-chain remodeling ; • positive regulation of protein catabolic process ; • phosphatidic acid biosynthetic process ; • metabolism ; • surfactant homeostasis ; • negative regulation of phosphatidylcholine biosynthetic process ; • phosphatidylcholine acyl-chain remodeling ; • phospholipid metabolic process ; • phosphatidylcholine biosynthetic process ; • neutrophil degranulation ;
	Sources:Amigo / QuickGO
Orthologs
	79888
	210992
	ENSG00000275079 ; ENSG00000153395
	ENSMUSG00000021608
	Q8NF37
	Q3TFD2
	NM_024830
	NM_145376 ; NM_001368681 ; NM_001368682
	NP_079106
	NP_663351 ; NP_001355610 ; NP_001355611
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated April 13, 2020

Lysophosphatidylcholine acyltransferase 1 is a protein in humans that is encoded by the LPCAT1 gene.^[5]

Lysophosphatidylcholine (LPC) acyltransferase (LPCAT; EC 2.3.1.23) catalyzes the conversion of LPC to phosphatidylcholine (PC) in the remodeling pathway of PC biosynthesis.^[6]

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References

1 2 3 ENSG00000153395 GRCh38: Ensembl release 89: ENSG00000275079, ENSG00000153395 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000021608 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Entrez Gene: Lysophosphatidylcholine acyltransferase 1".
↑ Nakanishi H, Shindou H, Hishikawa D, Harayama T, Ogasawara R, Suwabe A, Taguchi R, Shimizu T (2006). "Cloning and characterization of mouse lung-type acyl-CoA:lysophosphatidylcholine acyltransferase 1 (LPCAT1). Expression in alveolar type II cells and possible involvement in surfactant production". J. Biol. Chem. 281 (29): 20140–7. doi: 10.1074/jbc.M600225200 . PMID 16704971.

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[refGRCh38Ensembl-1] 1 2 3 ENSG00000153395 GRCh38: Ensembl release 89: ENSG00000275079, ENSG00000153395 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000021608 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: Lysophosphatidylcholine acyltransferase 1".

[pmid16704971-6] Nakanishi H, Shindou H, Hishikawa D, Harayama T, Ogasawara R, Suwabe A, Taguchi R, Shimizu T (2006). "Cloning and characterization of mouse lung-type acyl-CoA:lysophosphatidylcholine acyltransferase 1 (LPCAT1). Expression in alveolar type II cells and possible involvement in surfactant production". J. Biol. Chem. 281 (29): 20140–7. doi: 10.1074/jbc.M600225200 . PMID 16704971.