Alumni
- Note: Individuals may be listed in more than one category.
Government, law, and public policy
- Francis L. Bodine – former member of New Jersey General Assembly
- Kevin J. Boyle – member of Pennsylvania House of Representatives since 2011
- William J. Burns – United States Ambassador to Jordan; Deputy Secretary of State 2011–2014; head of Carnegie Endowment for International Peace
- John F. Byrne Sr. – Pennsylvania State Senator for the 8th district 1951–1952, Philadelphia City Councilman
- Billy Ciancaglini – Republican nominee for mayor of Philadelphia, 2019
- Tina Davis – member of Pennsylvania House of Representatives
- Madeleine Dean – U.S. Congresswoman
- Joseph DeFelice – former chair of Philadelphia GOP and current Trump appointee
- Joseph T. Doyle – Pennsylvania State Representative for the 163rd district 1971–78
- Michael Driscoll – businessman, member of Philadelphia City Council since 2022, founder of the iconic Philadelphia Irish pub Finnigan's Wake
- Dwight Evans, U.S. Congressman from Pennsylvania's 2nd congressional district
- Edward Fenlon – former member of Michigan House of Representatives and jurist
- Brian Fitzpatrick – U.S. Congressman from Pennsylvania's 8th congressional district
- Tom Gola – NBA Naismith Hall of Fame basketball player; Philadelphia City Controller 1970–71
- William F. Harrity – National Chairman of Democratic Party (1892–1896)
- Tom Houghton – former Pennsylvania State Representative
- William F. Keller – member of Pennsylvania House of Representatives
- Jim Kenney – Mayor of Philadelphia 2016–2024
- Emmett Joseph Leahy (1910–1964) – archivist and entrepreneur, pioneer in the discipline of records management
- Joanna E. McClinton – Pennsylvania State Representative since 2015
- Tom Murt – Pennsylvania State Representative from the 152nd district
- Dennis M. O'Brien – Speaker of Pennsylvania House of Representatives; Philadelphia City Councilman
- Michael H. O'Brien – Pennsylvania House of Representatives
- Mark Squilla – member of Philadelphia City Council
- Michael J. Stack III – Lieutenant Governor of Pennsylvania alongside Tom Wolf
- Sarah Wescott-Williams – first Prime Minister of Country Saint Maarten (2010–2014)
- John Waldron – American criminal defense lawyer
- Chris Wogan – former Pennsylvania representative and judge
Business
- Tom Curley – co-creator, former President of USA Today
- Larry Miller – President of the Jordan Brand
- Thomas M Feeney-President & CEO- Safelite Group (Safelite AutoGlass); Chairman Emeritus
Academia & education
- Stephen Andriole – Thomas G. Labrecque Chair of Business Technology at Villanova University
- John D. Caputo – Thomas J. Watson Professor of Humanities at Syracuse University; founder of weak theology
- Naomi Halas – Stanley C. Moore Professor in Electrical and Computer Engineering and Professor in Chemistry at Rice University
- Paula Krebs – Executive Director of the Modern Language Association (MLA), 2017–present
- Michael McGinniss – President of Christian Brothers University, 1994–1999, and La Salle University, 1999–2014
Literature
- Michael F. Flynn – science fiction author
- Charles Fuller – playwright, winner of the Pulitzer Prize
- Jack McDevitt – science fiction author
- Matthew Quick – author
Fine arts
- John McShain – builder of The Pentagon, Jefferson Memorial, and Kennedy Center
Entertainment
- Jessica Barth – actress
- Peter Boyle – Emmy award winning actor
- Ralph Garman – actor, voice actor
Journalism and media
- Adam Bagni – sportscaster
- Tom Curley – founder of USA Today , former CEO of AP
- A.J. Daulerio – editor-in-chief of Gawker , Deadspin , The Small Bow
- Brady Hicks – wrestling journalist
- Tim Legler – NBA, ESPN analyst
- Meredith Marakovits – YES Network reporter
- Jillian Mele – former host at Fox News, current host at WPVI-TV
- Bill Raftery – ESPN and CBS Sports college basketball analyst
- Gary Smith – sportswriter
Miscellaneous
- Michael William Brescia – convicted bank robber, part of the Midwest Bank Robbers group
- Johnny Dougherty – labor leader
- Walter P. Lomax Jr. – medical practitioner
Athletics
American football
- Mike Mandarino – NFL
- George Somers – NFL
Soccer
- Cesidio Colasante – MLS draft pick
- John McCarthy – goalkeeper for the Philadelphia Union
- Courtney Niemiec – defender for the Portland Thorns FC
- Ryan Richter – defender for Ottawa Fury FC
Basketball
- Michael Brooks – NBA and Europe; professional career lasted 1980–2008
- Joe Bryant – NBA and Europe, father of Kobe Bryant, former head coach of Los Angeles Sparks of WNBA
- Rasual Butler – last played for the San Antonio Spurs; died on January 31, 2018
- Larry Cannon – ABA player
- Fran Dunphy – head coach for La Salle Explorers men's basketball
- Larry Foust – 8-time NBA All-Star (1951–1956, 1958–1959)
- Ramon Galloway – professional basketball player
- Tom Gola – enshrined in Naismith Memorial Basketball Hall of Fame in 1976; NBA champion (1956); 5-time NBA All-Star (1960–1964); No. 15 retired by La Salle
- B.J. Johnson – current NBA player
- Tim Legler – NBA, analyst for ESPN's NBA coverage
- Ralph Lewis – NBA player
- Joe Mihalich – head coach of Hofstra University men's basketball
- Larry Miller – former President of NBA's Portland Trail Blazers; president of Jordan Brand
- Jeff Neubauer – head coach of Eastern Kentucky University men's basketball
- Doug Overton – NBA, played in 11 NBA seasons for eight different teams; head coach for Springfield Armor
- Jim Phelan – basketball player and coach
- Tom Piotrowski – (basketball) NBA, FIBA, CBA
- Bill Raftery – ESPN and CBS Sports college basketball analyst
- Cheryl Reeve – head coach of WNBA's Minnesota Lynx; by percentage the winningest coach in league's history, most postseason games of any WNBA coach
- Lionel Simmons – NBA, third-leading scorer in NCAA history; drafted 7th overall by Sacramento Kings in 1990
- Steven Smith – NBA, Serie A player
- Christian Standhardinger – BBL player
- Fatty Taylor – ABA, NBA player
- Randy Woods – NBA player
- Stephen Zack (born 1992), basketball player for Hapoel Holon in the Israeli Basketball Premier League
Olympians
La Salle Olympians have won a total of seven medals (five gold, and two bronze) in 12 Olympic Games.
- Diane Bracalente – field hockey, Seoul 1988
- Michael Brooks – captain of the boycotted 1980 basketball team
- Al Cantello – track and field, Rome 1960
- Stan Cwiklinski – rowing, gold medal, men's eight, Tokyo 1964
- Ira Davis – track and field, Rome 1960; placed 4th in the triple jump
- Hugh Foley – rowing, gold medal, men's eight, Tokyo 1964
- Charles Kieffer – rowing, gold medal, men's pair with coxswain, Los Angeles 1932
- Kathy McGahey – field hockey, bronze medal, Los Angeles 1984
- Diane Moyer – field hockey, Moscow 1980; bronze medal, Los Angeles 1984
- Cheryl Reeve - USA Women's Basketball, Paris 2024, head coach of the goal medal team
- John Uelses – first person to pole vault 16' (4.88 m), setting the world record (failed to qualify at trials)
- Joe Verdeur – swimming, gold medal, in 200 meter breaststroke, London 1948
