| Ambassador | Rank | Term | Nominated by | Appointed by | Accredited to |
|---|
| Carlos Creus y Camps | Chargé d'affaires | 1845–1851 [2] | | Isabella II | Manuel Oribe |
| Jacinto Albístur [ es ] | Chargé d'affaires | 1851 |
| José María de Alós | Chargé d'affaires | 1851–1854 [4] | The Marquess of Miraflores |
| Antonio Cuyás y Sampere [ es ] | Chargé d'affaires | 1854–1855 | | |
| Jacinto Albístur [ es ] [a] | Minister | 1855–1859 [5] | Claudio Antón de Luzuriaga | Venancio Flores |
| Carlos Creus y Camps | Chargé d'affaires | 1859–1861 [6] | | |
| Minister | 1861–1864 [7] | Bernardo Prudencio Berro |
Juan Pío de Montúfar y García-Infante, Marquess of Selva Alegre | Minister | 1864 [8] | Joaquín Francisco Pacheco | Venancio Flores |
| Carlos Creus y Camps | Minister | 1864–1873 [9] | Alejandro Llorente y Lannas | Atanasio Aguirre |
| José Mellado | Minister | 1873–1874 [10] | José Muro y López-Salgado | Francesc Pi i Margall | |
| Tiburcio Rodríguez y Muñoz [ es ] | Minister | 1874–1875 [11] | Augusto Ulloa y Castañón | The Duke of the Tower | José Eugenio Ellauri |
| Mariano Potestad | Chargé d'affaires | 1875–1877 [12] | Alejandro de Castro y Casal | Alfonso XII | Pedro Varela |
| Lorenzo de Castellanos | Chargé d'affaires | 1877–1879 [13] | Manuel Silvela y Le Vielleuze | Lorenzo Latorre |
| Manuel Llorente y Vázquez | Chargé d'affaires | 1879–1883 | |
| Emilio de Ojeda y Perpiñán [ es ] | Minister | 1883–1884 | Máximo Santos |
| Manuel del Palacio [ es ] | Minister | 1884–1886 [14] | The Marquess of the Pazo de la Merced |
| Julio de Arellano y Arróspide | Minister | 1886–1888 [15] | Francisco Antonino Vidal |
| Enrique Dupuy de Lôme | Minister | 1888–1890 | The Marquess of Vega de Armijo | Alfonso XIII | Máximo Tajes |
José Brunetti y Gayoso, Duke of Arcos | Minister | 1890–1891 | The Duke of Tetuán | Julio Herrera y Obes |
| José Delavat y Áreas | Minister | 1891 | |
| José de la Rica y Calvo | Minister | 1891–1894 |
| Ramiro Gil y Uribarri Ossorio | Minister | 1894–1898 [16] | Segismundo Moret | Juan Idiarte Borda |
| Juan Pérez-Caballero y Ferrer | Minister | 1898–1900 [17] | The Duke of Almodóvar | Juan Lindolfo Cuestas |
| Felipe García-Ontiveros y Serrano | Minister | 1900–1905 | | Juan Lindolfo Cuestas |
| Fernando Osorio y Elola | Minister | 1905–1907 | José Batlle y Ordóñez |
| Germán María de Ory y Morey | Minister | 1907–1910 [18] | Juan Pérez-Caballero y Ferrer | Claudio Williman |
Joaquín Gutiérrez Valcárcel, Marquess of Medina | Minister | 1911–1914 [19] | The Marquess of Alhucemas |
| Silvio Fernández-Vallín y Alfonso | Minister | 1914–1919 [20] | The Duke of Ripalda | José Batlle y Ordóñez |
Tomás de Rueda y Osborne, Viscount of Fuente de Doña María | Minister | 1919–1922 [21] | The Count of Romanones | Baltasar Brum |
| Manuel García de Acilu y Benito | Minister | 1922–1925 [22] | Joaquín Fernández Prida |
| Gonzalo del Río y García | Minister | 1925–1926 | | José Serrato |
| Alfonso Danvila [ es ] | Minister | 1926–1930 [23] | The Viscount of Santa Clara de Avedillo |
| Antonio Pla y da Folgueira | Minister | 1930–1933 [24] | The Duke of Alba | Juan Campisteguy |
| Enrique Díez Canedo | Minister | 1933–1934 [25] | Luis de Zulueta | Niceto Alcalá-Zamora | Gabriel Terra |
| Antonio de la Cruz Marín | Minister | 1934 [26] | Juan José Rocha García |
| Carlos Malagarriga y Munué | Minister | 1934–1935 [27] |
| Plácido Álvarez-Buylla | Minister | 1935–1936 [28] |
| Augusto Barcia Trelles | Minister | 1936–1939 [29] | Bernardo Giner de los Ríos | Manuel Azaña |
| José María Doussinague | Minister | 1939–1940 [30] | Francisco Gómez-Jordana Sousa | Francisco Franco | Alfredo Baldomir |
| Luis Martínez de Irujo y Caro | Minister | 1940–1943 [31] | Juan Luis Beigbeder |
| Teodomiro de Aguilar y Salas | Minister | 1943–1944 [32] | Francisco Gómez-Jordana Sousa | Juan José de Amézaga |
| Juan Pablo de Lojendio e Irure [ es ] | Minister | 1944–1951 [33] | José Félix de Lequerica y Erquiza |
Carlos Cañal y Gómez-Imaz [ es ], Marquess of Saavedra | Minister | 1951–1953 [34] | Alberto Martín-Artajo | Andrés Martínez Trueba |
| Ambassador | 1953–1959 [35] | Andrés Martínez Trueba |
| Francisco Javier Conde [ es ] | Ambassador | 1959–1964 [36] | Fernando María Castiella | Martín Echegoyen |
| Rafael Ferrer Sagreras | Ambassador | 1964–1970 [37] | Luis Giannattasio |
| Juan Serrat y Valera | Ambassador | 1970–1972 [38] | Gregorio López-Bravo | Jorge Pacheco Areco |
| Ramón Sáenz de Heredia y de Manzanos | Ambassador | 1972–1976 [39] | Juan María Bordaberry |
| Román Oyarzun Marchesi [ es ] | Ambassador | 1976–1980 [40] | Adolfo Martín-Gamero (acting) | Juan Carlos I |
| Rafael Gómez-Jordana y Prats | Ambassador | 1980–1983 [41] | José Pedro Pérez-Llorca | Aparicio Méndez |
| Félix Guillermo Fernández-Shaw Baldasano [ es ] | Ambassador | 1983–1987 [42] | Fernando Morán | Gregorio Conrado Álvarez |
| Federico Garayalde Emparan | Ambassador | 1988–1991 [43] | Francisco Fernández Ordóñez | Julio María Sanguinetti |
Salvador Bermúdez de Castro y Bernales [ es ], Marquess of Lema | Ambassador | 1991–1995 [44] | Luis Alberto Lacalle |
| Ricardo Peidró [ es ] | Ambassador | 1995–1996 [45] | Javier Solana | Julio María Sanguinetti |
| Joaquín María de Arístegui Laborde [ es ] | Ambassador | 1996–2001 [46] | Abel Matutes |
| Fernando Martínez Westerhausen | Ambassador | 2001–2004 [47] | Josep Piqué | Jorge Batlle |
| Fernando Valderrama Pareja [ es ] | Ambassador | 2004–2008 [48] | Miguel Ángel Moratinos |
| Aurora Díaz-Rato Revuelta [ es ] | Ambassador | 2008–2012 [49] | Tabaré Vázquez |
| Roberto Varela [ es ] | Ambassador | 2012–2017 [50] | José Manuel García-Margallo | José Mujica |
| Javier Sangro [ es ] | Ambassador | 2017–2019 [51] | Alfonso Dastis | Felipe VI | Tabaré Vázquez |
| José Javier Gómez-Llera [ es ] | Ambassador | 2019–2022 [52] | Josep Borrell |
| Santiago Jiménez Martín [ es ] | Ambassador | 2022–2025 [53] | José Manuel Albares | Luis Lacalle Pou |
| Javier Salido Ortiz [ es ] | Ambassador | 2025–pres. [54] |