Elizabeth Ann, a black-footed ferret female, was born on December 10, 2020, at the Fish and Wildlife Service's Black-footed Ferret Conservation Center in Colorado. She is a clone of a female named Willa, who died in the mid-1980s and left no living descendants. [3]
Injaz, a cloned female dromedary camel, was born in 2009 at the Camel Reproduction Center in Dubai, United Arab Emirates [5] after an "uncomplicated" gestation of 378 days. [6]
Embryologist Tong Dizhou successfully inserted the DNA from a male Asian carp into the egg of a female Asian carp to create the first fish clone in 1963. [7]
Sooam Biotech, Korea cloned eight coyotes in 2011 using domestic dogs as surrogate mothers. [29]
In 1958, John Gurdon, then at Oxford University, explained that he had successfully cloned a frog. He did this by using intact nuclei from somatic cells from a Xenopus tadpole. [38] This was an important extension of work of Briggs and King in 1952 on transplanting nuclei from embryonic blastula cells. [39]
Five genetically identical fruit flies were produced at the lab of Dr. Vett Lloyd at Dalhousie University in Halifax, Nova Scotia, Canada in 2005. [40]
Gaur, a species of wild cattle, was the first endangered species to be cloned. In 2001, at the Trans Ova Genetics in Sioux Center, Iowa, United States, a cloned gaur was born from a surrogate domestic cow mother. However, the calf died within 48 hours. [41]
In 2024 it was announced that a rhesus macaque named Retro had been cloned by a SCNT technique. [62]
Cloning is the process of producing individual organisms with identical genomes, either by natural or artificial means. In nature, some organisms produce clones through asexual reproduction; this reproduction of an organism by itself without a mate is known as parthenogenesis. In the field of biotechnology, cloning is the process of creating cloned organisms of cells and of DNA fragments.
Dolly was a female Finn-Dorset sheep and the first mammal that was cloned from an adult somatic cell. She was cloned by associates of the Roslin Institute in Scotland, using the process of nuclear transfer from a cell taken from a mammary gland. Her cloning proved that a cloned organism could be produced from a mature cell from a specific body part. Contrary to popular belief, she was not the first animal to be cloned.
Human cloning is the creation of a genetically identical copy of a human. The term is generally used to refer to artificial human cloning, which is the reproduction of human cells and tissue. It does not refer to the natural conception and delivery of identical twins. The possibilities of human cloning have raised controversies. These ethical concerns have prompted several nations to pass laws regarding human cloning.
Przewalski's horse, also called the takhi, Mongolian wild horse or Dzungarian horse, is a rare and endangered horse originally native to the steppes of Central Asia. It is named after the Russian geographer and explorer Nikolay Przhevalsky. Once extinct in the wild, since the 1990s it has been reintroduced to its native habitat in Mongolia in the Khustain Nuruu National Park, Takhin Tal Nature Reserve, and Khomiin Tal, as well as several other locales in Central Asia and Eastern Europe.
In genetics and developmental biology, somatic cell nuclear transfer (SCNT) is a laboratory strategy for creating a viable embryo from a body cell and an egg cell. The technique consists of taking a denucleated oocyte and implanting a donor nucleus from a somatic (body) cell. It is used in both therapeutic and reproductive cloning. In 1996, Dolly the sheep became famous for being the first successful case of the reproductive cloning of a mammal. In January 2018, a team of scientists in Shanghai announced the successful cloning of two female crab-eating macaques from foetal nuclei.
Commercial animal cloning is the cloning of animals for commercial purposes, including animal husbandry, medical research, competition camels and horses, pet cloning, and restoring populations of endangered and extinct animals. The practice was first demonstrated in 1996 with Dolly the sheep.
Nuclear transfer is a form of cloning. The step involves removing the DNA from an oocyte, and injecting the nucleus which contains the DNA to be cloned. In rare instances, the newly constructed cell will divide normally, replicating the new DNA while remaining in a pluripotent state. If the cloned cells are placed in the uterus of a female mammal, a cloned organism develops to term in rare instances. This is how Dolly the Sheep and many other species were cloned. Cows are commonly cloned to select those that have the best milk production. On 24 January 2018, two monkey clones were reported to have been created with the technique for the first time.
Hwang Woo-suk is a South Korean veterinarian and researcher. He was a professor of theriogenology and biotechnology at Seoul National University until he was dismissed on March 20, 2006. He was considered a pioneering expert in stem cell research and even called the "Pride of Korea". However, he became infamous around November 2005 for fabricating a series of stem cell experiments that were published in high-profile journals, the case known as the Hwang affair.
In bioethics, the ethics of cloning concerns the ethical positions on the practice and possibilities of cloning, especially of humans. While many of these views are religious in origin, some of the questions raised are faced by secular perspectives as well. Perspectives on human cloning are theoretical, as human therapeutic and reproductive cloning are not commercially used; animals are currently cloned in laboratories and in livestock production.
A frozen zoo is a storage facility in which genetic materials taken from animals are stored at very low temperatures (−196 °C) in tanks of liquid nitrogen. Material preserved in this way can be stored indefinitely and used for artificial insemination, in vitro fertilization, embryo transfer, and cloning. There are a few frozen zoos across the world that implement this technology for conservation efforts. Several different species have been introduced to this technology, including the Pyrenean ibex, Black-footed ferret, and potentially the white rhinoceros.
Keith Henry Stockman Campbell was a British biologist who was a member of the team at Roslin Institute that in 1996 first cloned a mammal, a Finnish Dorset lamb named Dolly, from fully differentiated adult mammary cells. He was Professor of Animal Development at the University of Nottingham. In 2008, he received the Shaw Prize for Medicine and Life Sciences jointly with Ian Wilmut and Shinya Yamanaka for "their works on the cell differentiation in mammals".
Interspecific pregnancy is the pregnancy involving an embryo or fetus belonging to another species than the carrier. Strictly, it excludes the situation where the fetus is a hybrid of the carrier and another species, thereby excluding the possibility that the carrier is the biological mother of the offspring. Strictly, interspecific pregnancy is also distinguished from endoparasitism, where parasite offspring grow inside the organism of another species, not necessarily in the womb.
The revival of the woolly mammoth is a proposed hypothetical that frozen soft-tissue remains and DNA from extinct woolly mammoths could be a means of regenerating the species. Several methods have been proposed to achieve this goal, including cloning, artificial insemination, and genome editing. Whether or not it is ethical to create a live mammoth is debated.
Noori was a female pashmina goat, the first pashmina goat to be cloned using the process of nuclear transfer. Born on 9 March 2012, she was kept at the place of her birth, at the Faculty of Veterinary Sciences and Animal Husbandry, Sher-e-Kashmir University of Agricultural Sciences and Technology of Kashmir, Shuhama, Srinagar in the Indian territory of Jammu and Kashmir.
The Pyrenean ibex, Aragonese and Spanish common name bucardo, Basque common name bukardo, Catalan common name herc and French common name bouquetin, was one of the four subspecies of the Iberian ibex or Iberian wild goat, a species endemic to the Pyrenees. Pyrenean ibex were most common in the Cantabrian Mountains, Southern France, and the northern Pyrenees. This species was common during the Holocene and Upper Pleistocene, during which their morphology, primarily some skulls, of the Pyrenean ibex was found to be larger than other Capra subspecies in southwestern Europe from the same time.
Morné de la Rey is a South African veterinary surgeon and embryo transfer specialist. In 2003, he was one of a team of scientists and veterinarians from his company Embryo Plus and the Danish Agriculture Institute to clone a cow, the first animal to be cloned in Africa. In 2016, he was one of a team to use in vitro fertilisation successfully for the first time in the Cape buffalo.
Zhong Zhong and Hua Hua are a pair of identical crab-eating macaques that were created through somatic cell nuclear transfer (SCNT), the same cloning technique that produced Dolly the sheep in 1996. They are the first cloned primates produced by this technique. Unlike previous attempts to clone monkeys, the donated nuclei came from fetal cells, not embryonic cells. The primates were born from two independent surrogate pregnancies at the Institute of Neuroscience of the Chinese Academy of Sciences in Shanghai.
Mu-ming Poo is a Chinese neuroscientist. He is the Paul Licht Distinguished Professor Emeritus at the University of California, Berkeley and the Founding Director of the Shanghai-based Institute of Neuroscience (ION) of the Chinese Academy of Sciences. He was awarded the 2016 Gruber Prize in Neuroscience for his pioneering work on synaptic plasticity. At ION, Poo led a team of scientists that produced the world's first truly cloned primates, a pair of crab-eating macaques called Zhongzhong and Huahua in 2017, using somatic cell nuclear transfer (SCNT).
Revive & Restore is a nonprofit wildlife conservation organization focused on use of biotechnology in conservation. Headquartered in Sausalito, California, the organization's mission is to enhance biodiversity through the genetic rescue of endangered and extinct species. The organization was founded by Stewart Brand and his wife, Ryan Phelan.
Maya is a cloned female arctic wolf that was born from a beagle surrogate mother in China. She was born on June 10, 2022, and news of her birth was revealed to the public on September 19 of the same year at Harbin Polarland, in China's Heilongjiang Province, by the biotechnology company Sinogene.
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