Mallotus oppositifolius

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Mallotus oppositifolius
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At University of Abomey-Calavi, Benin
Scientific classification OOjs UI icon edit-ltr.svg
Kingdom: Plantae
Clade: Tracheophytes
Clade: Angiosperms
Clade: Eudicots
Clade: Rosids
Order: Malpighiales
Family: Euphorbiaceae
Genus: Mallotus
Species:
M. oppositifolius
Binomial name
Mallotus oppositifolius
Varieties

M. oppositifolius var. genuinus
M. oppositifolius var. glabratus
M. oppositifolius var. integrifolius
M. oppositifolius var. lindicus
M. oppositifolius var. pubescens

Mallotus oppositifolius is a plant species in the genus Mallotus found in Africa and Madagascar.

The variety Mallotus oppositifolius var. lindicus is classified in the IUCN red list of vulnerable species of plants. [2]

The aqueous and ethanol extracts of the plant show antifungal properties, [3] and anti parasitic activity against blastocystis hominis. [4] The bioassay-guided fractionation of an ethanol extract of the leaves and inflorescence of M. oppositifolius collected in Madagascar led to the isolation of the two new bioactive dimeric phloroglucinols mallotojaponins B and C, together with mallotophenone. These compounds show antiproliferative and antiplasmodial (antimalarial) activities. [5] Two components of M. oppositifolius leaf extract, MTX and isovaleric acid, synergistically activate heteromeric KCNQ2/3 (potassium) channels, indicating the molecular mechanism behind the anticonvulsant properties of this widely used African traditional medicine [6]


References

  1. ↑ Beentje, H.J.; Gereau, R.E.; Hilton-Taylor, C.; Howard, G.; Kindeketa, W.; Luke, W.R.Q.; Maunder, M.; Mwachala, G.; Mwangoka, M.; Ndangalasi, H.; Njau, E.-F.; Schatz, G.E.; Siro Masinde, P.; Wilkins, V.L. (2020). "Mallotus oppositifolius". IUCN Red List of Threatened Species . 2020: e.T62455A3114823. doi: 10.2305/IUCN.UK.2020-3.RLTS.T62455A3114823.en . Retrieved 18 November 2021.
  2. ↑ Lovett, J.; Clarke, G.P. (1998). "Mallotus oppositifolius var. lindicus". IUCN Red List of Threatened Species . 1998: e.T35791A9953219. doi: 10.2305/IUCN.UK.1998.RLTS.T35791A9953219.en . Retrieved 18 November 2021.
  3. ↑ Adekunle, AA; Ikumapayi, AM (2006). "Antifungal property and phytochemical screening of the crude extracts of Funtumia elastica and Mallotus oppositifolius". The West Indian Medical Journal. 55 (4): 219–23. doi:10.1590/s0043-31442006000400003. PMID   17249309.
  4. ↑ Bremer Christensen, C.; Soelberg, J.; Stensvold, CR.; Jäger, AK. (March 2015). "Activity of medicinal plants from Ghana against the parasitic gut protist Blastocystis". J Ethnopharmacol. 174: 569–75. doi:10.1016/j.jep.2015.03.006. PMID   25773490.
  5. ↑ Harinantenaina, Liva; Bowman, Jessica D.; Brodie, Peggy J.; Slebodnick, Carla; Callmander, Martin W.; Rakotobe, Etienne; Randrianaivo, Richard; Rasamison, Vincent E.; Gorka, Alexander; Roepe, Paul D.; Cassera, Maria B.; Kingston, David G. I. (2013). "Antiproliferative and Antiplasmodial Dimeric Phloroglucinols from Mallotus oppositifolius from the Madagascar Dry Forest(1)". Journal of Natural Products. 76 (3): 388–93. doi:10.1021/np300750q. PMC   3606680 . PMID   23286240.
  6. ↑ De Silva, AM; Manville, RW; Abbott, GW (2018). "Deconstruction of an African folk medicine uncovers a novel molecular strategy for therapeutic potassium channel activation". Sci Adv. 4: eaav0824. doi:10.1126/sciadv.aav0824. PMC   6235520 . PMID   30443601.


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