Provincial Trunk Highway 1 is Manitoba's section of the Trans-Canada Highway. It is a heavily used, 4-lane divided highway, with the exception of a short 18 km section in the southeastern corner of the province. It is the main link between southern Manitoba's largest cities, and also serves as the province's main transportation link to the neighbouring provinces of Saskatchewan and Ontario. The highway is the only major east-west divided highway in Manitoba, and carries a large majority of east-west traffic within and through the province. It has full freeway status sections at Portage la Prairie and Winnipeg. The total distance of the Trans-Canada Highway in Manitoba is approximately 490 km (300 mi).
Provincial Trunk Highway 16 (PTH 16) is a provincial highway in the Canadian province of Manitoba. It is the Manitoba section of the Yellowhead Highway, and also the Trans-Canada Highway Yellowhead section. The main purpose of this highway is to connect Winnipeg with other Canadian cities such as Saskatoon and Edmonton. The highway runs from Bloom at an intersection with the Trans-Canada Highway and Provincial Road 305 ten kilometres (6.2 mi) west of Portage la Prairie to the Saskatchewan boundary sixteen kilometres (9.9 mi) west of Russell, where it continues as Saskatchewan Highway 16.
Provincial Trunk Highway 6 is a provincial primary highway located in the Canadian province of Manitoba. It runs from the Perimeter Highway of Winnipeg to the Thompson south city limits. It is also the main highway connecting Winnipeg to northern Manitoba. The speed limit is 100 km/h. The route is also used to deliver nickel from the Thompson mine to the Royal Canadian Mint in Winnipeg. The section of highway between its southern terminus near Winnipeg and the second junction with PTH 68 near Eriksdale is part of the Northern Woods and Water Route. The portion of the highway between Ponton and Thompson was known as Highway 391 prior to 1986.
Provincial Trunk Highway 2 is a 315-kilometre (196-mile) highway in the Canadian province of Manitoba. It runs from Highway 13 at the Manitoba-Saskatchewan border to Winnipeg's Perimeter Highway near Oak Bluff.
Provincial Trunk Highway 3 is a major provincial highway located in the Canadian province of Manitoba. It runs from the Saskatchewan boundary to the southwest city limits of Winnipeg, where it continues as Winnipeg Route 155. Prior before to the implementation of Winnipeg's City Route System, it extended to Pembina Highway.
Provincial Trunk Highway 5 is a provincial primary highway located in the Canadian province of Manitoba.
The Northern Woods and Water Route is a 2,400-kilometre (1,500 mi) route through northern British Columbia, Alberta, Saskatchewan and Manitoba in Western Canada. As early as the 1950s, community groups came together to establish a northern travel route; this was proposed as the Northern Yellowhead Transportation Route. The Northern Woods and Water Route Association was established in 1974, and encouraged promotion of the route with the promise of an increase in tourist travel. The route was designated in 1974 and is well signed throughout its component highways. The route starts at Dawson Creek as the Spirit River Highway and ends at the Perimeter of Winnipeg, Manitoba, after running through the northern regions of the western provinces. From west to east, the Northern Woods and Water Route (NWWR) incorporates portions of British Columbia Highway 49; Alberta Highways 49, 2A, 2, & 55; Saskatchewan Highways 55 & 9; Manitoba Provincial Road 283 and Trunk Highways 10, 5, 68 & 6. The halfway point of the NWWR is approximately at Goodsoil, Saskatchewan.
Provincial Trunk Highway 10 is a provincial primary highway located in the Canadian province of Manitoba.
Highway 49 and Provincial Trunk Highway 49 is a provincial highway in the Canadian provinces of Saskatchewan and Manitoba. Most of the highway is in the east-central part of Saskatchewan and only a very short section is in Manitoba. It runs from Saskatchewan Highway 35 between the communities of Fosston and Hendon to the Saskatchewan — Manitoba border, before ending at Provincial Trunk Highway 83 south of the community of Benito. The combined highway is about 166.4 kilometres (103.4 mi) in length — 165.2 kilometres (102.7 mi) is in Saskatchewan and 1.2 kilometres (0.7 mi) is in Manitoba.
Provincial Trunk Highway 24 is a provincial highway in the Canadian province of Manitoba. It is an east–west route that runs from PTH 83 near Miniota, east through Oak River and Rapid City to the junction of PTH 10 and PR 262 between Brandon and Minnedosa.
Provincial Trunk Highway 25 is a provincial highway in the Canadian province of Manitoba. It is a short east-west route starting at PR 259 at Wheatland, east through Rivers, and terminating at PTH 10 six kilometres (3.7 mi) north of Forrest. PTH 25 serves as the major route, via PTH 10, between Rivers and Brandon.
Provincial Trunk Highway 83 is a major north-south highway that runs in the far western region of the Canadian province of Manitoba. It travels from the North Dakota border south of Melita, north through Virden, Birtle, Russell, and Roblin to its northern terminus with PTH 10 in the town of Swan River. Along with US 83, PTH 83 is part of a continuously numbered north-south highway in North America with a combined distance of 3,450 kilometres (2,140 mi).
Provincial Trunk Highway 50 is a provincial highway in the south-central region of the Canadian province of Manitoba. It runs from PTH 16 to PTH 5 and PR 361 in the village of McCreary.
Provincial Trunk Highway 45 is a provincial highway in the Parkland Region of the Canadian province of Manitoba. It runs from PTH 16 and PTH 83 in the town of Russell to PTH 10 five kilometres (3.1 mi) north of the village of Erickson.
Provincial Trunk Highway 41 is a short provincial highway in the far southwest region of the Canadian province of Manitoba. It runs from PTH 1 and PR 542 in the village of Kirkella to PTH 16 and PTH 83 just south of Binscarth.
Manitoba Provincial Road 355 is an east-west provincial road in the southwestern section of the Canadian province of Manitoba.
Manitoba Provincial Road 354 is a provincial road in the southwestern section of the Canadian province of Manitoba.
Provincial Road 243 is an east-west provincial road in the extreme south-central region of the Canadian province of Manitoba. It runs from PTH 75 near Emerson to PTH 32 near Reinland. Along the route, it passes north of Gretna using a small concurrence with PTH 30.
Highway 57 and Provincial Trunk Highway 57 are two short highways in the Canadian provinces of Saskatchewan and Manitoba.
Provincial Road 482 is provincial road in the far western part of the Canadian province of Manitoba.
Hwy 5 at Manitoba - Saskatchewan border near Togo 
PR 484 south
PTH 83 near San Clara 
