Methionine transaminase

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Methionine transaminase
Identifiers
EC no. 2.6.1.88
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum
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PMC articles
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NCBI proteins

Methionine transaminase (EC 2.6.1.88, methionine-oxo-acid transaminase) is an enzyme with systematic name L-methionine:2-oxo-acid aminotransferase. [1] [2] [3] This enzyme catalyses the following chemical reaction

L-methionine + 2-oxo carboxylate 2-oxo-4-methylthiobutanoate + L-amino acid

The enzyme is most active with L-methionine.

References

  1. Heilbronn J, Wilson J, Berger BJ (March 1999). "Tyrosine aminotransferase catalyzes the final step of methionine recycling in Klebsiella pneumoniae". Journal of Bacteriology. 181 (6): 1739–47. doi:10.1128/JB.181.6.1739-1747.1999. PMC   93571 . PMID   10074065.
  2. Dolzan M, Johansson K, Roig-Zamboni V, Campanacci V, Tegoni M, Schneider G, Cambillau C (July 2004). "Crystal structure and reactivity of YbdL from Escherichia coli identify a methionine aminotransferase function". FEBS Letters. 571 (1–3): 141–6. Bibcode:2004FEBSL.571..141D. doi: 10.1016/j.febslet.2004.06.075 . PMID   15280032.
  3. Schuster J, Knill T, Reichelt M, Gershenzon J, Binder S (October 2006). "Branched-chain aminotransferase4 is part of the chain elongation pathway in the biosynthesis of methionine-derived glucosinolates in Arabidopsis". The Plant Cell. 18 (10): 2664–79. Bibcode:2006PlanC..18.2664S. doi:10.1105/tpc.105.039339. PMC   1626624 . PMID   17056707.