 | |
| Company type | Public company |
|---|---|
| Industry | Pharmaceutical industry |
| Founded | 1995 |
| Headquarters | Oxford |
Key people | Frank Mathias (CEO) |
| Revenue |  £89.5 million (2023) [1] |
| £(184.2) million (2023) [1] | |
| £(184.2) million (2023) [1] | |
| Website | https://oxb.com/ |
Oxford Biomedica (OXB) is a gene and cell therapy company specialising in the development of gene-based medicines. It is listed on the London Stock Exchange. [2]
The company was established in 1995 as a spin out from the University of Oxford. [3] It was the subject of an initial public offering on the Alternative Investment Market in 1996. [4]
In 2018, OXBs gene therapy for Parkinson's disease became the subject of a commercialization deal with Axovant Sciences. [5]
In May 2019, the company announced an investment by Novo Holdings for a stake of 10.1% in OXB, totalling $55 million (USD) to develop its gene therapy technology. [6] The firm had already established collaborations with Sanofi, Novartis and other groups to provide lentiviral vector manufacturing. [7]
In November 2019, Microsoft announced a partnership with OXB to improve the next generation of cell and gene delivery technology using the cloud and machine learning, contributing large data sets for analysis via the Microsoft Azure intelligent cloud platform to develop in-silico models and novel algorithms to help provide long-term and curative treatments for a wide range of diseases. [8]
In December 2019, the company announced that it has extended its commercial supply agreement with Novartis for the manufacture of lentiviral vectors for the Novartis CAR-T portfolio including five lentiviral vectors for CAR-T products, which builds on the existing three-year commercial supply agreement signed by the parties in July 2017. [9]
In April 2020, OXB announced that the company had joined a Consortium led by the Jenner Institute, Oxford University, to develop and manufacture a vaccine for COVID-19: ChAdOx1 nCov-19. [10] This is one of the vaccines currently being deployed under a conditional authorisation. [11] [12]
In September 2023, it was announced OXB had acquired the Illkirch-Graffenstaden-headquartered, viral vectors drug product manufacturing services company, ABL Europe from the Mérieux Institute. [13]
Gene therapy is a medical technology that aims to produce a therapeutic effect through the manipulation of gene expression or through altering the biological properties of living cells.
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C.H. Boehringer Sohn AG & Co. KG is the parent company of the Boehringer Ingelheim group, which was founded in 1885 by Albert Boehringer (1861–1939) in Ingelheim am Rhein, Germany. As of 2018, Boehringer Ingelheim is one of the world's largest pharmaceutical companies, and the largest private one. Headquartered in Ingelheim, it operates globally with 146 affiliates and more than 47,700 employees. Unlike most large pharmaceutical companies which are listed, the company is private and fully owned by the Boehringer, Liebrecht and von Baumbach families. The company's key areas of interest are: respiratory diseases, metabolism, immunology, oncology and diseases of the central nervous system. Boehringer Ingelheim is a full member of the European Federation of Pharmaceutical Industries and Associations (EFPIA). The corporate logo of Boehringer Ingelheim depicts a stylized rendition of the central section of the imperial palace of Charlemagne.
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ProSavin is an experimental drug believed to be of use in the treatment of Parkinson's disease. It is administered to the striatum in the brain, inducing production of dopamine.
Lentiviral vectors in gene therapy is a method by which genes can be inserted, modified, or deleted in organisms using lentiviruses.
Samsung Biologics Co., Ltd. is a global contract development and manufacturing organization headquartered in Songdo, Incheon, South Korea. The biotech division of Samsung Group, its core services range from late discovery to large-scale commercial manufacturing. The company focuses on monoclonal antibodies, bispecific antibodies, antibody-drug conjugates, and mRNA vaccines.
Betibeglogene autotemcel, sold under the brand name Zynteglo, is a gene therapy for the treatment for beta thalassemia. It was developed by Bluebird Bio and was given breakthrough therapy designation by the US Food and Drug Administration in February 2015.
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Pierre Charneau is a French virologist, inventor, and head of the Molecular Virology and Vaccinology Unit (VMV) at the Pasteur Institute and an acknowledged specialist in HIV, lentiviral gene transfer vectors, and their medical applications. His discovery of the central DNA-flap structure in the HIV genome, and its role in viral entry into the nucleus of the infected cell, grounded the optimization of lentiviral vectors and allowed for more than 20 years of development in gene therapy and vaccines based on this gene delivery technology. Charneau has published more than 100 research articles and holds 25 patents in the field of HIV and lentiviral vectors.
GenScript Biotech, fully known as GenScript Biotech Corporation, usually referred to as simply GenScript, is a New Jersey-based biotech company. It was co-founded in 2002 in New Jersey by Fangliang Zhang, Ye Wang, and Luquan Wang. The company mainly provides life science research application instruments and services. It was listed on the Hong Kong Stock Exchange in 2015. The current rotating CEO of the firm is Shao Weihui, who also served as the chief operating officer and Chinese Communist Party Committee Secretary for the company. The company's main subsidiaries include Legend Biotech, ProBio Technology, and Bestzyme.
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