PSME2

PSME2
Identifiers
Aliases	PSME2 , PA28B, PA28beta, REGbeta, proteasome activator subunit 2
External IDs	OMIM: 602161 MGI: 1096365 HomoloGene: 86889 GeneCards: PSME2
Gene location (Human)
Chr.	Chromosome 14 (human) [1]
End	24,147,570 bp [1]
Gene location (Mouse)
Chr.	Chromosome 14 (mouse) [2]
End	55,591,113 bp [2]
RNA expression pattern
	More reference expression data
Gene ontology
Molecular function	• endopeptidase activator activity ; • GO:0001948 protein binding ; • identical protein binding ;
Cellular component	• cytoplasm ; • cytosol ; • membrane ; • proteasome activator complex ; • nucleoplasm ; • proteasome complex ; • extracellular exosome ;
Biological process	• positive regulation of endopeptidase activity ; • regulation of proteasomal protein catabolic process ; • regulation of cellular amino acid metabolic process ; • antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent ; • regulation of mRNA stability ; • positive regulation of canonical Wnt signaling pathway ; • protein polyubiquitination ; • stimulatory C-type lectin receptor signaling pathway ; • tumor necrosis factor-mediated signaling pathway ; • MAPK cascade ; • Fc-epsilon receptor signaling pathway ; • regulation of G1/S transition of mitotic cell cycle ; • NIK/NF-kappaB signaling ; • negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle ; • anaphase-promoting complex-dependent catabolic process ; • T cell receptor signaling pathway ; • positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition ; • negative regulation of canonical Wnt signaling pathway ; • proteasome-mediated ubiquitin-dependent protein catabolic process ; • Wnt signaling pathway, planar cell polarity pathway ; • negative regulation of G2/M transition of mitotic cell cycle ; • protein deubiquitination ; • SCF-dependent proteasomal ubiquitin-dependent protein catabolic process ; • transmembrane transport ; • regulation of transcription from RNA polymerase II promoter in response to hypoxia ; • post-translational modification ; • interleukin-12-mediated signaling pathway ; • regulation of hematopoietic stem cell differentiation ; • interleukin-1-mediated signaling pathway ; • regulation of mitotic cell cycle phase transition ;
	Sources:Amigo / QuickGO
Orthologs
	5721
	19188
	ENSG00000100911 ; ENSG00000284889
	ENSMUSG00000079197
	Q9UL46
	P97372
	NM_002818
	NM_001029855 ; NM_011190
	NP_002809
	NP_001268401 ; NP_001025026 ; NP_035320
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated April 16, 2020

Proteasome activator complex subunit 2 is a protein that in humans is encoded by the PSME2 gene.^[5]^[6]

Function

The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. The immunoproteasome contains an alternate regulator, referred to as the 11S regulator or PA28, that replaces the 19S regulator. Three subunits (alpha, beta and gamma) of the 11S regulator have been identified. This gene encodes the beta subunit of the 11S regulator, one of the two 11S subunits that is induced by gamma-interferon. Three beta and three alpha subunits combine to form a heterohexameric ring. Six pseudogenes have been identified on chromosomes 4, 5, 8, 10 and 13.^[6]

Interactions

PSME2 has been shown to interact with PSME1.^[7]^[8]

Related Research Articles

26S protease regulatory subunit 6A, also known as 26S proteasome AAA-ATPase subunit Rpt5, is an enzyme that in humans is encoded by the PSMC3 gene. This protein is one of the 19 essential subunits of a complete assembled 19S proteasome complex Six 26S proteasome AAA-ATPase subunits together with four non-ATPase subunits form the base sub complex of 19S regulatory particle for proteasome complex.

Proteasome subunit beta type-4 also known as 20S proteasome subunit beta-7 is a protein that in humans is encoded by the PSMB4 gene.

26S proteasome non-ATPase regulatory subunit 10 or gankyrin is an enzyme that in humans is encoded by the PSMD10 gene. Gankyrin is an oncoprotein that is a component of the 19S regulatory cap of the proteasome. Structurally, it contains a 33-amino acid ankyrin repeat that forms a series of alpha helices. It plays a key role in regulating the cell cycle via protein-protein interactions with the cyclin-dependent kinase CDK4. It also binds closely to the E3 ubiquitin ligase MDM2, which is a regulator of the degradation of p53 and retinoblastoma protein, both transcription factors involved in tumor suppression and found mutated in many cancers. Gankyrin also has an anti-apoptotic effect and is overexpressed in certain types of tumor cells such as hepatocellular carcinoma.

26S proteasome non-ATPase regulatory subunit 5 is an enzyme that in humans is encoded by the PSMD5 gene.

26S proteasome non-ATPase regulatory subunit 4, also as known as 26S Proteasome Regulatory Subunit Rpn10, is an enzyme that in humans is encoded by the PSMD4 gene. This protein is one of the 19 essential subunits that contributes to the complete assembly of 19S proteasome complex.

26S protease regulatory subunit 7, also known as 26S proteasome AAA-ATPase subunit Rpt1, is an enzyme that in humans is encoded by the PSMC2 gene This protein is one of the 19 essential subunits of a complete assembled 19S proteasome complex. Six 26S proteasome AAA-ATPase subunits together with four non-ATPase subunits form the base sub complex of 19S regulatory particle for proteasome complex.

Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 is a protein that in humans is encoded by the GNB1 gene.

Proteasome activator complex subunit 1 is a protein that in humans is encoded by the PSME1 gene.

Proteasome subunit beta type-5 as known as 20S proteasome subunit beta-5 is a protein that in humans is encoded by the PSMB5 gene. This protein is one of the 17 essential subunits that contributes to the complete assembly of 20S proteasome complex. In particular, proteasome subunit beta type-5, along with other beta subunits, assemble into two heptameric rings and subsequently a proteolytic chamber for substrate degradation. This protein contains "chymotrypsin-like" activity and is capable of cleaving after large hydrophobic residues of peptide. The eukaryotic proteasome recognized degradable proteins, including damaged proteins for protein quality control purpose or key regulatory protein components for dynamic biological processes. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides.

26S protease regulatory subunit 4, also known as 26S proteasome AAA-ATPase subunit Rpt2, is an enzyme that in humans is encoded by the PSMC1 gene. This protein is one of the 19 essential subunits of a complete assembled 19S proteasome complex. Six 26S proteasome AAA-ATPase subunits together with four non-ATPase subunits form the base sub complex of 19S regulatory particle for proteasome complex.

Proteasome activator complex subunit 3 is a protein that in humans is encoded by the PSME3 gene.

26S protease regulatory subunit 6B, also known as 26S proteasome AAA-ATPase subunit Rpt3,is an enzyme that in humans is encoded by the PSMC4 gene. This protein is one of the 19 essential subunits of a complete assembled 19S proteasome complex Six 26S proteasome AAA-ATPase subunits together with four non-ATPase subunits form the base sub complex of 19S regulatory particle for proteasome complex.

5'-AMP-activated protein kinase subunit beta-1 is an enzyme that in humans is encoded by the PRKAB1 gene.

Proteasome inhibitor PI31 subunit is a protein that in humans is encoded by the PSMF1 gene.

5'-AMP-activated protein kinase subunit gamma-2 is an enzyme that in humans is encoded by the PRKAG2 gene.

Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 is a protein that in humans is encoded by the GNB2 gene.

Eukaryotic translation initiation factor 2 subunit 2 (eIF2β) is a protein that in humans is encoded by the EIF2S2 gene.

Guanine nucleotide-binding protein subunit beta-5 is a protein that in humans is encoded by the GNB5 gene. Alternatively spliced transcript variants encoding different isoforms exist.

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3 is a protein that in humans is encoded by the GNG3 gene.

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4 is a protein that in humans is encoded by the GNG4 gene.

References

1 2 3 ENSG00000284889 GRCh38: Ensembl release 89: ENSG00000100911, ENSG00000284889 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000079197 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Ahn JY, Tanahashi N, Akiyama K, Hisamatsu H, Noda C, Tanaka K, Chung CH, Shibmara N, Willy PJ, Mott JD (Jul 1995). "Primary structures of two homologous subunits of PA28, a gamma-interferon-inducible protein activator of the 20S proteasome". FEBS Lett. 366 (1): 37–42. doi:10.1016/0014-5793(95)00492-R. PMID 7789512.
1 2 "Entrez Gene: PSME2 proteasome (prosome, macropain) activator subunit 2 (PA28 beta)".
↑ Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (Oct 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature . 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514.
↑ Ahn K, Erlander M, Leturcq D, Peterson PA, Früh K, Yang Y (Jul 1996). "In vivo characterization of the proteasome regulator PA28". J. Biol. Chem. 271 (30): 18237–42. doi: 10.1074/jbc.271.30.18237 . PMID 8663520.

Coux O, Tanaka K, Goldberg AL (1996). "Structure and functions of the 20S and 26S proteasomes". Annu. Rev. Biochem. 65: 801–47. doi:10.1146/annurev.bi.65.070196.004101. PMID 8811196.
Sijts A, Sun Y, Janek K, Kral S, Paschen A, Schadendorf D, Kloetzel PM (2002). "The role of the proteasome activator PA28 in MHC class I antigen processing". Mol. Immunol. 39 (3–4): 165–9. doi:10.1016/S0161-5890(02)00099-8. PMID 12200048.
Goff SP (2003). "Death by deamination: a novel host restriction system for HIV-1". Cell. 114 (3): 281–3. doi:10.1016/S0092-8674(03)00602-0. PMID 12914693.
Dubiel W, Pratt G, Ferrell K, Rechsteiner M (1992). "Purification of an 11 S regulator of the multicatalytic protease". J. Biol. Chem. 267 (31): 22369–77. PMID 1429590.
Mott JD, Pramanik BC, Moomaw CR, Afendis SJ, DeMartino GN, Slaughter CA (1995). "PA28, an activator of the 20 S proteasome, is composed of two nonidentical but homologous subunits". J. Biol. Chem. 269 (50): 31466–71. PMID 7989312.
Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
Ahn K, Erlander M, Leturcq D, Peterson PA, Früh K, Yang Y (1996). "In vivo characterization of the proteasome regulator PA28". J. Biol. Chem. 271 (30): 18237–42. doi: 10.1074/jbc.271.30.18237 . PMID 8663520.
Seeger M, Ferrell K, Frank R, Dubiel W (1997). "HIV-1 tat inhibits the 20 S proteasome and its 11 S regulator-mediated activation". J. Biol. Chem. 272 (13): 8145–8. doi: 10.1074/jbc.272.13.8145 . PMID 9079628.
McCusker D, Jones T, Sheer D, Trowsdale J (1998). "Genetic relationships of the genes encoding the human proteasome beta subunits and the proteasome PA28 complex". Genomics. 45 (2): 362–7. doi:10.1006/geno.1997.4948. PMID 9344661.
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Wójcik C, Tanaka K, Paweletz N, Naab U, Wilk S (1999). "Proteasome activator (PA28) subunits, alpha, beta and gamma (Ki antigen) in NT2 neuronal precursor cells and HeLa S3 cells". Eur. J. Cell Biol. 77 (2): 151–60. doi:10.1016/s0171-9335(98)80083-6. PMID 9840465.
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[refGRCh38Ensembl-1] 1 2 3 ENSG00000284889 GRCh38: Ensembl release 89: ENSG00000100911, ENSG00000284889 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000079197 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid7789512-5] Ahn JY, Tanahashi N, Akiyama K, Hisamatsu H, Noda C, Tanaka K, Chung CH, Shibmara N, Willy PJ, Mott JD (Jul 1995). "Primary structures of two homologous subunits of PA28, a gamma-interferon-inducible protein activator of the 20S proteasome". FEBS Lett. 366 (1): 37–42. doi:10.1016/0014-5793(95)00492-R. PMID 7789512.

[entrez-6] 1 2 "Entrez Gene: PSME2 proteasome (prosome, macropain) activator subunit 2 (PA28 beta)".

[pmid16189514-7] Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (Oct 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature . 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514.

[pmid8663520-8] Ahn K, Erlander M, Leturcq D, Peterson PA, Früh K, Yang Y (Jul 1996). "In vivo characterization of the proteasome regulator PA28". J. Biol. Chem. 271 (30): 18237–42. doi: 10.1074/jbc.271.30.18237 . PMID 8663520.

v t e Proteasome endopeptidase complex subunits (EC 3.4.25.1)
A (alpha subunits)	PSMA1 PSMA2 PSMA3 PSMA4 PSMA5 PSMA6 PSMA7 PSMA8
B (beta subunits)	PSMB1 PSMB2 PSMB3 PSMB4 PSMB5 PSMB6 PSMB7 PSMB8 PSMB9 PSMB10
C (ATPases)	PSMC1 PSMC2 PSMC3 PSMC4 PSMC5 PSMC6
D (non-ATPases)	PSMD1 PSMD2 PSMD3 PSMD4 PSMD5 PSMD6 PSMD7 PSMD8 PSMD9 PSMD10 PSMD11 PSMD12 PSMD13 PSMD14
E (activator subunits)	PSME1 PSME2 PSME3 PSME4
F (inhibitor subunit)	PSMF1

PSME2

Contents

Function

Interactions

Related Research Articles

References

Further reading