PSMF1

Last updated
PSMF1
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases PSMF1 , PI31, proteasome inhibitor subunit 1
External IDs OMIM: 617858 MGI: 1346072 HomoloGene: 38231 GeneCards: PSMF1
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_144889
NM_212446
NM_001305244

RefSeq (protein)

NP_001292173
NP_997611

Location (UCSC) Chr 20: 1.11 – 1.19 Mb Chr 2: 151.72 – 151.74 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Proteasome inhibitor PI31 subunit is a protein that in humans is encoded by the PSMF1 gene. [5] [6]

Contents

Function

The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a protein that inhibits the activation of the proteasome by the 11S and 19S regulators. Alternative transcript variants have been identified for this gene. [6]

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000125818 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000032869 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Tanahashi N, Kawahara H, Murakami Y, Tanaka K (Apr 1999). "The proteasome-dependent proteolytic system". Molecular Biology Reports. 26 (1–2): 3–9. doi:10.1023/A:1006909522731. PMID   10363639. S2CID   38305744.
  6. 1 2 "Entrez Gene: PSMF1 proteasome (prosome, macropain) inhibitor subunit 1 (PI31)".

Further reading