Peptidoglycan-N-acetylglucosamine deacetylase

Peptidoglycan-N-acetylglucosamine deacetylase
Identifiers
EC no.	3.5.1.104
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Search PMC articles PubMed articles NCBI proteins

Peptidoglycan-N-acetylglucosamine deacetylase (EC 3.5.1.104, HP310, PgdA, SpPgdA, BC1960, peptidoglycan deacetylase, N-acetylglucosamine deacetylase, peptidoglycan GlcNAc deacetylase, peptidoglycan N-acetylglucosamine deacetylase, PG N-deacetylase) is an enzyme with systematic name peptidoglycan-N-acetylglucosamine amidohydrolase. ^{[1] [2] [3] [4] [5] [6]} This enzyme catalyses the following chemical reaction

peptidoglycan-N-acetyl-D-glucosamine + H₂O ${\displaystyle \rightleftharpoons }$ peptidoglycan-D-glucosamine + acetate

This enzyme contributes to virulence of Helicobacter pylori , Listeria monocytogenes and Streptococcus suis .

References

1. Psylinakis E, Boneca IG, Mavromatis K, Deli A, Hayhurst E, Foster SJ, Vårum KM, Bouriotis V (September 2005). "Peptidoglycan N-acetylglucosamine deacetylases from Bacillus cereus, highly conserved proteins in Bacillus anthracis". The Journal of Biological Chemistry. 280 (35): 30856–63. doi: 10.1074/jbc.m407426200 . PMID   15961396.
2. Tsalafouta A, Psylinakis E, Kapetaniou EG, Kotsifaki D, Deli A, Roidis A, Bouriotis V, Kokkinidis M (March 2008). "Purification, crystallization and preliminary X-ray analysis of the peptidoglycan N-acetylglucosamine deacetylase BC1960 from Bacillus cereus in the presence of its substrate (GlcNAc)6". Acta Crystallographica Section F. 64 (Pt 3): 203–5. doi:10.1107/s1744309108002510. PMC   2374148 . PMID   18323609.
3. Blair DE, Schüttelkopf AW, MacRae JI, van Aalten DM (October 2005). "Structure and metal-dependent mechanism of peptidoglycan deacetylase, a streptococcal virulence factor". Proceedings of the National Academy of Sciences of the United States of America. 102 (43): 15429–34. Bibcode:2005PNAS..10215429B. doi: 10.1073/pnas.0504339102 . PMC   1252587 . PMID   16221761.
4. Wang G, Olczak A, Forsberg LS, Maier RJ (March 2009). "Oxidative stress-induced peptidoglycan deacetylase in Helicobacter pylori". The Journal of Biological Chemistry. 284 (11): 6790–800. doi: 10.1074/jbc.m808071200 . PMC   2652260 . PMID   19147492.
5. Popowska M, Kusio M, Szymanska P, Markiewicz Z (September 2009). "Inactivation of the wall-associated de-N-acetylase (PgdA) of Listeria monocytogenes results in greater susceptibility of the cells to induced autolysis". Journal of Microbiology and Biotechnology. 19 (9): 932–45. doi:10.4014/jmb.0810.557. PMID   19809250.
6. Fittipaldi N, Sekizaki T, Takamatsu D, de la Cruz Domínguez-Punaro M, Harel J, Bui NK, Vollmer W, Gottschalk M (December 2008). "Significant contribution of the pgdA gene to the virulence of Streptococcus suis". Molecular Microbiology. 70 (5): 1120–35. doi: 10.1111/j.1365-2958.2008.06463.x . PMID   18990186.

External links

• Peptidoglycan-N-acetylglucosamine+deacetylase at the U.S. National Library of Medicine Medical Subject Headings (MeSH)