Dihydroorotase

carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase
Dihydroorotase (fragment) dimer, Human
Identifiers
Symbol	CAD
NCBI gene	790
HGNC	1424
OMIM	114010
RefSeq	NM_004341
UniProt	P27708
Other data
EC number	3.5.2.3
Locus	Chr. 2 p22-p21
Search for Structures Swiss-model Domains InterPro

Dihydroorotase (EC 3.5.2.3, carbamoylaspartic dehydrase, dihydroorotate hydrolase) is an enzyme which converts carbamoyl aspartic acid into 4,5-dihydroorotic acid in the biosynthesis of pyrimidines. ^{[1] [2]} It forms a multifunctional enzyme with carbamoyl phosphate synthetase and aspartate transcarbamoylase. Dihydroorotase is a zinc metalloenzyme. ^[3]

See also

• Pyrimidine biosynthesis

References

1. Cooper C, Wilson DW (1954). "Biosynthesis of pyrimidines". Fed. Proc. 13: 194.
2. Lieberman I, Kornberg A (April 1954). "Enzymatic synthesis and breakdown of a pyrimidine, orotic acid. I. Dihydroortic acid, ureidosuccinic acid, and 5-carboxymethylhydantoin" (PDF). The Journal of Biological Chemistry. 207 (2): 911–24. doi: 10.1016/S0021-9258(18)65708-4 . PMID   13163076.
3. Voet, Donald (2011). Biochemistry. Judith G. Voet. Hoboken, NJ: John Wiley & Sons. ISBN   978-0-470-57095-1. OCLC   690489261.

External links

• Dihydroorotase at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
• EC 3.5.2.3