Cytidine deaminase

CDA
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1MQ0
Identifiers
Aliases	CDA , CDD, cytidine deaminase
External IDs	OMIM: 123920 MGI: 1919519 HomoloGene: 1352 GeneCards: CDA
Gene location (Human)
Chr.	Chromosome 1 (human)
End	20,618,903 bp
Gene location (Mouse)
Chr.	Chromosome 4 (mouse)
End	138,367,992 bp
RNA expression pattern
	More reference expression data
Gene ontology
Molecular function	• protein homodimerization activity ; • nucleoside binding ; • cytidine deaminase activity ; • zinc ion binding ; • metal ion binding ; • GO:0001948 protein binding ; • catalytic activity ; • identical protein binding ; • hydrolase activity ;
Cellular component	• cytosol ; • extracellular region ; • secretory granule lumen ; • tertiary granule lumen ; • ficolin-1-rich granule lumen ;
Biological process	• cytosine metabolic process ; • pyrimidine nucleoside salvage ; • cell surface receptor signaling pathway ; • cytidine deamination ; • negative regulation of cell growth ; • pyrimidine-containing compound salvage ; • negative regulation of nucleotide metabolic process ; • protein homotetramerization ; • neutrophil degranulation ;
	Sources:Amigo / QuickGO
Orthologs
	978
	72269
	ENSG00000158825
	ENSMUSG00000028755
	P32320
	P56389
	NM_001785
	NM_028176
	NP_001776
	NP_082452
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated August 27, 2021

Cytidine deaminase is an enzyme that in humans is encoded by the CDA gene.^[5]^[6]^[7]

This gene encodes an enzyme involved in pyrimidine salvaging. The encoded protein forms a homotetramer that catalyzes the irreversible hydrolytic deamination of cytidine and deoxycytidine to uridine and deoxyuridine, respectively. It is one of several deaminases responsible for maintaining the cellular pyrimidine pool. Mutations in this gene are associated with decreased sensitivity to the cytosine nucleoside analogue cytosine arabinoside used in the treatment of certain childhood leukemias.^[7] Most cytidine deaminases act on RNA, and the few that act on DNA require ssDNA.^[8]

A related activation-induced (cytidine) deaminase (AID) regulates antibody diversification, especially the process of somatic hypermutation.

Interactive pathway map

Click on genes, proteins and metabolites below to link to respective articles.^{[§ 1]}

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|alt=Fluorouracil (5-FU) Activity edit]]

Fluorouracil (5-FU) Activity edit

↑ The interactive pathway map can be edited at WikiPathways: "FluoropyrimidineActivity_WP1601".

Related Research Articles

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Adenosine deaminase is an enzyme involved in purine metabolism. It is needed for the breakdown of adenosine from food and for the turnover of nucleic acids in tissues.

Activation-induced cytidine deaminase, also known as AICDA, AID and single-stranded DNA cytosine deaminase, is a 24 kDa enzyme which in humans is encoded by the AICDA gene. It creates mutations in DNA by deamination of cytosine base, which turns it into uracil. In other words, it changes a C:G base pair into a U:G mismatch. The cell's DNA replication machinery recognizes the U as a T, and hence C:G is converted to a T:A base pair. During germinal center development of B lymphocytes, AID also generates other types of mutations, such as C:G to A:T. The mechanism by which these other mutations are created is not well understood. It is a member of the APOBEC family.

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Purine nucleoside phosphorylase, PNP, PNPase or inosine phosphorylase is an enzyme that in humans is encoded by the NP gene. It catalyzes the chemical reaction

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Apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3A, also known as APOBEC3A, or A3A is a gene of the APOBEC3 family found in humans, non-human primates, and some other mammals. It is a single-domain DNA cytidine deaminase with antiviral effects. While other members of the family such as APOBEC3G are believed to act by editing ssDNA by removing an amino group from cytosine in DNA, introducing a cytosine to uracil change which can ultimately lead to a cytosine to thymine mutation, one study suggests that APOBEC3A can inhibit parvoviruses by another mechanism. The cellular function of APOBEC3A is likely to be the destruction of foreign DNA through extensive deamination of cytosine.Stenglein MD, Burns MB, Li M, Lengyel J, Harris RS. "APOBEC3 proteins mediate the clearance of foreign DNA from human cells". Nature Structural & Molecular Biology. 17 (2): 222–9. doi:10.1038/nsmb.1744. PMC 2921484. PMID 20062055.

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APOBEC Enzyme involved in messenger RNA editing

APOBEC is a family of evolutionarily conserved cytidine deaminases.

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References

1 2 3 GRCh38: Ensembl release 89: ENSG00000158825 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000028755 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Kühn K, Bertling WM, Emmrich F (January 1993). "Cloning of a functional cDNA for human cytidine deaminase (CDD) and its use as a marker of monocyte/macrophage differentiation". Biochemical and Biophysical Research Communications. 190 (1): 1–7. doi:10.1006/bbrc.1993.1001. PMID 8422236.
↑ Demontis S, Terao M, Brivio M, Zanotta S, Bruschi M, Garattini E (December 1998). "Isolation and characterization of the gene coding for human cytidine deaminase". Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression. 1443 (3): 323–33. doi:10.1016/s0167-4781(98)00235-8. PMID 9878810.
1 2 "Entrez Gene: CDA cytidine deaminase".
↑ Komor AC, Kim YB, Packer MS, Zuris JA, Liu DR (May 2016). "Programmable editing of a target base in genomic DNA without double-stranded DNA cleavage". Nature. 533 (7603): 420–4. Bibcode:2016Natur.533..420K. doi:10.1038/nature17946. PMC 4873371 . PMID 27096365.

External links

Overview of all the structural information available in the PDB for UniProt : P32320 (Cytidine deaminase) at the PDBe-KB .

This article on a gene on human chromosome 1 is a stub. You can help Wikipedia by expanding it.

This page is based on this Wikipedia article
Text is available under the CC BY-SA 4.0 license; additional terms may apply.
Images, videos and audio are available under their respective licenses.

[WikiPathways-9] The interactive pathway map can be edited at WikiPathways: "FluoropyrimidineActivity_WP1601".

[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000158825 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000028755 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8422236-5] Kühn K, Bertling WM, Emmrich F (January 1993). "Cloning of a functional cDNA for human cytidine deaminase (CDD) and its use as a marker of monocyte/macrophage differentiation". Biochemical and Biophysical Research Communications. 190 (1): 1–7. doi:10.1006/bbrc.1993.1001. PMID 8422236.

[pmid9878810-6] Demontis S, Terao M, Brivio M, Zanotta S, Bruschi M, Garattini E (December 1998). "Isolation and characterization of the gene coding for human cytidine deaminase". Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression. 1443 (3): 323–33. doi:10.1016/s0167-4781(98)00235-8. PMID 9878810.

[entrez-7] 1 2 "Entrez Gene: CDA cytidine deaminase".

[8] Komor AC, Kim YB, Packer MS, Zuris JA, Liu DR (May 2016). "Programmable editing of a target base in genomic DNA without double-stranded DNA cleavage". Nature. 533 (7603): 420–4. Bibcode:2016Natur.533..420K. doi:10.1038/nature17946. PMC 4873371 . PMID 27096365.

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[§ 1]

v t e Hydrolases: carbon-nitrogen non-peptide (EC 3.5)
3.5.1: Linear amides / Amidohydrolases	Asparaginase Glutaminase Urease Biotinidase Aspartoacylase Ceramidase Aspartylglucosaminidase Fatty acid amide hydrolase Histone deacetylase Sirtuin
3.5.2: Cyclic amides/ Amidohydrolases	Barbiturase Beta-lactamase Dihydroorotase
3.5.3: Linear amidines/ Ureohydrolases	Arginase Agmatinase Protein-arginine deiminase
3.5.4: Cyclic amidines/ Aminohydrolases	Guanine deaminase Adenosine deaminase AMP deaminase Inosine monophosphate synthase DCMP deaminase GTP cyclohydrolase I Cytidine deaminase AICDA Activation-induced cytidine deaminase
3.5.5: Nitriles/ Aminohydrolases	Nitrilase
3.5.99: Other	Riboflavinase Thiaminase II

v t e Enzymes
Activity	Active site Binding site Catalytic triad Oxyanion hole Enzyme promiscuity Catalytically perfect enzyme Coenzyme Cofactor Enzyme catalysis
Regulation	Allosteric regulation Cooperativity Enzyme inhibitor Enzyme activator
Classification	EC number Enzyme superfamily Enzyme family List of enzymes
Kinetics	Enzyme kinetics Eadie–Hofstee diagram Hanes–Woolf plot Lineweaver–Burk plot Michaelis–Menten kinetics
Types	EC1 Oxidoreductases (list) EC2 Transferases (list) EC3 Hydrolases (list) EC4 Lyases (list) EC5 Isomerases (list) EC6 Ligases (list) EC7 Translocases (list)

Cytidine deaminase

Contents

Interactive pathway map

Related Research Articles

References

Further reading

External links