Names | |
---|---|
Preferred IUPAC name 1-[(2E)-3-(3,4,5-Trimethoxyphenyl)prop-2-enoyl]-5,6-dihydropyridin-2(1H)-one | |
Other names Piplartine | |
Identifiers | |
3D model (JSmol) | |
ChEMBL | |
ChemSpider | |
ECHA InfoCard | 100.243.690 |
PubChem CID | |
UNII | |
| |
| |
Properties | |
C17H19NO5 | |
Molar mass | 317.341 g·mol−1 |
Solubility | DMSO, DMF, ethanol [1] |
Hazards | |
GHS labelling: | |
Warning | |
H315, H319, H335 | |
P261, P264, P280 | |
Safety data sheet (SDS) | [1] |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). |
Piperlongumine (also called piplartine or piperlongumin) is an amide alkaloid constituent [2] of the fruit of the long pepper (Piper longum), a pepper plant found in southern India and southeast Asia. [3] When extracted, piperlongumine may cause skin, eye or respiratory tract irritation. [2]
Long peppers have been used in Ayurveda and traditional Chinese medicine as a treatment. [3] [4]
Targtex, a biotechnology spin-off of the Portuguese Institute for Molecular Biology, developed a piperlongumine hydrogel that is to be applied after the removal of Glioblastoma tumours, with the goal of neutralizing remaining cancer cells. The hydrogel was effective in laboratory and animal studies and is scheduled for Phase I human clinical trials sometime in 2023. [5] [6]
Black pepper is a flowering vine in the family Piperaceae, cultivated for its fruit, which is usually dried and used as a spice and seasoning. The fruit is a drupe (stonefruit) which is about 5 mm (0.20 in) in diameter, dark red, and contains a stone which encloses a single pepper seed. Peppercorns and the ground pepper derived from them may be described simply as pepper, or more precisely as black pepper, green pepper, or white pepper.
Povidone-iodine (PVP-I), also known as iodopovidone, is an antiseptic used for skin disinfection before and after surgery. It may be used both to disinfect the hands of healthcare providers and the skin of the person they are caring for. It may also be used for minor wounds. It may be applied to the skin as a liquid or a powder.
Pegfilgrastim, sold under the brand name Neulasta among others, is a PEGylated form of the recombinant human granulocyte colony-stimulating factor (GCSF) analog filgrastim. It serves to stimulate the production of white blood cells (neutrophils). Pegfilgrastim was developed by Amgen.
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