Putrescine aminotransferase

Putrescine aminotransferase
Identifiers
EC no.	2.6.1.82
CAS no.	98982-73- Science
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Search PMC articles PubMed articles NCBI proteins

Putrescine aminotransferase (EC 2.6.1.82, putrescine-alpha-ketoglutarate transaminase, YgjG, putrescine:alpha-ketoglutarate aminotransferase, PAT, putrescine:2-oxoglutarate aminotransferase, putrescine transaminase) is an enzyme with systematic name butane-1,4-diamine:2-oxoglutarate aminotransferase. ^{[1] [2] [3]} This enzyme catalyses the following chemical reaction

putrescine + 2-oxoglutarate ${\displaystyle \rightleftharpoons }$ 1-pyrroline + L-glutamate + H₂O (overall reaction)

(1a) putrescine + 2-oxoglutarate ${\displaystyle \rightleftharpoons }$ 4-aminobutanal + L-glutamate

(1b) 4-aminobutanal ${\displaystyle \rightleftharpoons }$ 1-pyrroline + H₂O (spontaneous)

This enzyme is a pyridoxal-phosphate protein.

References

1. Prieto-Santos MI, Martín-Checa J, Balaña-Fouce R, Garrido-Pertierra A (February 1986). "A pathway for putrescine catabolism in Escherichia coli". Biochimica et Biophysica Acta (BBA) - General Subjects. 880 (2–3): 242–4. doi:10.1016/0304-4165(86)90085-1. PMID   3510672.
2. Samsonova NN, Smirnov SV, Novikova AE, Ptitsyn LR (August 2005). "Identification of Escherichia coli K12 YdcW protein as a gamma-aminobutyraldehyde dehydrogenase". FEBS Letters. 579 (19): 4107–12. Bibcode:2005FEBSL.579.4107S. doi: 10.1016/j.febslet.2005.06.038 . PMID   16023116.
3. Samsonova NN, Smirnov SV, Altman IB, Ptitsyn LR (January 2003). "Molecular cloning and characterization of Escherichia coli K12 ygjG gene". BMC Microbiology. 3 (1) 2. doi: 10.1186/1471-2180-3-2 . PMC   150594 . PMID   12617754.

External links

• Putrescine+aminotransferase at the U.S. National Library of Medicine Medical Subject Headings (MeSH)