Pyrroline-2-carboxylate reductase

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pyrroline-2-carboxylate reductase
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EC no. 1.5.1.1
CAS no. 9029-16-7
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In enzymology, a pyrroline-2-carboxylate reductase (EC 1.5.1.1) is an enzyme that catalyzes the chemical reaction

L-proline + NAD(P)+ 1-pyrroline-2-carboxylate + NAD(P)H + H+

The 3 substrates of this enzyme are L-proline, NAD+, and NADP+, whereas its 4 products are 1-pyrroline-2-carboxylate, NADH, NADPH, and H+.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-NH group of donors with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is L-proline:NAD(P)+ 2-oxidoreductase. This enzyme is also called Delta1-pyrroline-2-carboxylate reductase. This enzyme participates in lysine degradation and arginine and proline metabolism.

Related Research Articles

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<span class="mw-page-title-main">Proline dehydrogenase</span>

In enzymology, proline dehydrogenase (PRODH) (EC 1.5.5.2, formerly EC 1.5.99.8) is an enzyme of the oxidoreductase family, active in the oxidation of L-proline to (S)-1-pyrroline-5-carboxylate during proline catabolism. The end product of this reaction is then further oxidized in a (S)-1-pyrroline-5-carboxylate dehydrogenase (P5CDH)-dependent reaction of the proline metabolism, or spent to produce ornithine, a crucial metabolite of ornithine and arginine metabolism. The systematic name of this enzyme class is L-proline:quinone oxidoreductase. Other names in common use include L-proline dehydrogenase, L-proline oxidase,and L-proline:(acceptor) oxidoreductase. It employs one cofactor, FAD, which requires riboflavin (vitamin B2).

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<span class="mw-page-title-main">PYCR1</span> Protein-coding gene in the species Homo sapiens

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<span class="mw-page-title-main">Aldehyde dehydrogenase 4 family, member A1</span> Protein-coding gene in the species Homo sapiens

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<span class="mw-page-title-main">Aldehyde dehydrogenase 18 family, member A1</span> Protein-coding gene in the species Homo sapiens

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<span class="mw-page-title-main">NOXRED1</span> Human gene

NADP Dependent Oxidoreductase Domain Containing 1 (NOXRED1) is a human protein encoded by the gene NADP-Dependent Oxidoreductase Domain Containing 1 (NOXRED1). An alias of this gene is Chromosome 14 Open Reading Frame 148 (c14orf148). This gene is located on chromosome 14, at 14q24.3. NOXRED1 is predicted to be involved in pyrroline-5-carboxylate reductase activity as part of the L-proline biosynthetic pathway. It is expressed in a wide variety of tissues at a relatively low level, including the testes, thyroid, skin, small intestine, brain, kidney, colon, and more.

References