Rothia (bacterium)

Rothia
Rothia dentocariosa , Gram stain.
Scientific classification
Domain:	Bacteria
Kingdom:	Bacillati
Phylum:	Actinomycetota
Class:	Actinomycetes
Order:	Micrococcales
Family:	Micrococcaceae
Genus:	Rothia Georg and Brown 1967 (Approved Lists 1980)
Type species
Rothia dentocariosa corrig. (Onishi 1949) Georg and Brown 1967 (Approved Lists 1980)
Species [1]
R. aeria Li et al. 2004 R. aerolata Kämpfer et al. 2016 R. amarae Fan et al. 2002 R. dentocariosa corrig. (Onishi 1949) Georg and Brown 1967 (Approved Lists 1980) R. endophytica Xiong et al. 2013 R. halotolerans (Tang et al. 2009) Nouioui et al. 2018 R. koreensis (Park et al. 2010) Nouioui et al. 2018 R. kristinae (Kloos et al. 1974) Nouioui et al. 2018 R. mucilaginosa (Bergan and Kocur 1982) Collins et al. 2000 R. nasimurium Collins et al. 2000 R. terrae Chou et al. 2008 R. uropygialis (Braun et al. 2018) Ghodhbane-Gtari et al. 2024 R. uropygioeca (Braun et al. 2018) Ghodhbane-Gtari et al. 2024
Synonyms [1]
StomatococcusBergan and Kocur 1982

Rothia is a Gram-positive, aerobic, rod-shaped and non-motile bacterial genus from the family Micrococcaceae. ^{[1] [2] [3]} Three species within Rothia have been shown to colonize humans: R. dentocariosa, R. mucilaginosa, and R. aeria ^{[4] [5] [6]} . These species are considered to be commensal, but they can cause disease in immunosuppressed humans. ^{[7] [8]}

Rothia spp. are prevalent in human saliva and produce enterobactin. They are also prevalent in the human gut and can cause the emergence of gastric atrophy and intestinal metaplasia. ^{[9] [10]}

Rothia spp. have been isolated from diverse habitats, including humans, livestock, and natural and built environments. ^[11] As of 2025, 13 species have been validly published and are recognized as members of the genus Rothia.

References

1. Parte, A.C. "Rothia". LPSN .
2. David E., Swayne; John R., Glisson; Larry R., McDougald; Lisa K., Nolan; David L., Suarez; Venugopal L., Nair (2013). Diseases of Poultry. John Wiley & Sons. ISBN   978-1-118-71973-2.
3. Austin, Brian (1 January 2015). "Rothia". Bergey's Manual of Systematics of Archaea and Bacteria. John Wiley & Sons, Ltd. pp. 1–13. doi:10.1002/9781118960608.gbm00124. ISBN   9781118960608.
4. Georg, L. K.; Brown, J. M. (1967-01-01). "Rothia, gen. nov. an aerobic genus of the family Actinomycetaceae" . International Journal of Systematic Bacteriology. 17 (1): 79–88. doi:10.1099/00207713-17-1-79. ISSN   0020-7713.
5. Collins, M D; Hutson, R A; Båverud, V; Falsen, E (2000-05-01). "Characterization of a Rothia-like organism from a mouse: description of Rothia nasimurium sp. nov. and reclassification of Stomatococcus mucilaginosus as Rothia mucilaginosa comb. nov" . International Journal of Systematic and Evolutionary Microbiology. 50 (3): 1247–1251. doi:10.1099/00207713-50-3-1247. ISSN   1466-5026. PMID   10843069.
6. Li, Ying; Kawamura, Yoshiaki; Fujiwara, Nagatoshi; Naka, Takashi; Liu, Hongsheng; Huang, Xinxiang; Kobayashi, Kazuo; Ezaki, Takayuki (2004). "Rothia aeria sp. nov., Rhodococcus baikonurensis sp. nov. and Arthrobacter russicus sp. nov., isolated from air in the Russian space laboratory Mir" . International Journal of Systematic and Evolutionary Microbiology. 54 (3): 827–835. doi:10.1099/ijs.0.02828-0. ISSN   1466-5034. PMID   15143031.
7. Schlossberg, David, ed. (2015). Clinical infectious disease (Second ed.). Cambridge, United Kingdom: Cambridge University Press. ISBN   9781107038912.
8. (Hrsg.), Gholamreza Darai; et al. (2012). Lexikon der Infektionskrankheiten des Menschen Erreger, Symptome, Diagnose, Therapie und Prophylaxe (4., vollständig überarbeitete und aktualisierte Aufl. ed.). Berlin: Springer. ISBN   978-3-642-17158-1.
9. Uranga, Carla; Arroyo, Pablo; Duggan, Brendan M.; Gerwick, William H.; Edlund, Anna (2020-02-20). "Commensal oral Rothia mucilaginosa produces enterobactin—a metal chelating siderophore" (PDF). doi:10.1101/2020.02.20.956391. S2CID   213599051 . Retrieved 2020-10-13.{{cite journal}}: Cite journal requires |journal= (help)
10. Sung, Joseph J Y; Coker, Olabisi Oluwabukola; Chu, Eagle; Szeto, Chun Ho; Luk, Simson Tsz Yat; Lau, Harry Cheuk Hay; Yu, Jun (2020-01-23). "Gastric microbes associated with gastric inflammation, atrophy and intestinal metaplasia 1 year after Helicobacter pylori eradication". Gut. 69 (9): 1572–1580. doi: 10.1136/gutjnl-2019-319826 . ISSN   0017-5749. PMC   7456733 . PMID   31974133.
11. West, Shannon R.; Suddaby, Allison B.; Lewin, Gina R.; Ibberson, Carolyn B. (2024-07-01). "Rothia" . Trends in Microbiology. 32 (7): 720–721. doi:10.1016/j.tim.2024.03.009. ISSN   0966-842X. PMID   38580605.

Further reading

• Ramanan, Poornima; Barreto, Jason N.; Osmon, Douglas R.; Tosh, Pritish K.; Diekema, D. J. (September 2014). "Rothia Bacteremia: a 10-Year Experience at Mayo Clinic, Rochester, Minnesota". Journal of Clinical Microbiology. 52 (9): 3184–3189. doi:10.1128/JCM.01270-14. PMC   4313135 . PMID   24951810.
• George M., Garrity (2012). Bergey's manual of systematic bacteriology (2nd ed.). New York: Springer Science + Business Media. ISBN   978-0-387-68233-4.