Schmallenberg orthobunyavirus

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Schmallenberg orthobunyavirus
Virus de Schmallenger.jpg
Schmallenberg virus
Virus classification OOjs UI icon edit-ltr.svg
(unranked): Virus
Realm: Riboviria
Kingdom: Orthornavirae
Phylum: Negarnaviricota
Class: Ellioviricetes
Order: Bunyavirales
Family: Peribunyaviridae
Genus: Orthobunyavirus
Species:
Schmallenberg orthobunyavirus
Synonyms
  • Schmallenberg virus

Schmallenberg orthobunyavirus, also called Schmallenberg virus, abbreviated SBV, is a virus that causes congenital malformations and stillbirths in cattle, sheep, goats, and possibly alpaca. [1] [2] It appears to be transmitted by midges ( Culicoides spp.), which are likely to have been most active in causing the infection in the Northern Hemisphere summer and autumn of 2011, with animals subsequently giving birth from late 2011. [1] Schmallenberg virus falls in the Simbu serogroup of orthobunyaviruses. It is considered to be most closely related to the Sathuperi and Douglas viruses. [3]

Contents

The virus is named after Schmallenberg, in North Rhine-Westphalia, Germany, from where the first definitive sample was derived. [1] It was first reported in October 2011. [4] After Germany, it has also been detected in the Netherlands, Belgium, France, Luxembourg, Italy, Spain, the United Kingdom, [5] Switzerland, [6] Ireland, [7] Finland, [8] Denmark, [9] Sweden, [10] Austria, [11] Norway, [11] Poland [11] and Estonia. [11]

The virus has been recognised by the European Commission's Standing Committee on the Food Chain and Animal Health [1] and the Friedrich-Loeffler-Institut (German Research Institute for Animal Health). [11] A risk assessment in December 2011 did not consider it likely to be a threat to human health, [12] as other comparable viruses are not zoonotic. [11]

Immunity can possibly be acquired naturally against SBV. It is possible that the seasonality of the infection cycle would not entail a second epidemic circulation next year, due to the shortness of the viraemic period (about 4 to 6 days post exposure, longer in affected foetuses). Vaccination is a possible option for controlling the disease as a vaccine exists for the similar Akabane virus. [13] In March 2012, scientists of the Friedrich-Loeffler-Institut first succeeded in producing an electron microscope image of the Schmallenberg virus. [14]

Molecular biology

Schmallenberg virus (SBV) virion and genome organization. Viruses-11-01065-g001.png
Schmallenberg virus (SBV) virion and genome organization.

The genetic structure of Schmallenberg virus is typical for Bunyavirales viruses, which are a family of enveloped negative-sense single stranded RNA viruses with a genome split into three parts—Small (S), Medium (M) and Large (L). The L RNA segment encodes an RNA-dependent RNA polymerase (L protein), the M RNA segment encodes two surface glycoproteins (Gc and Gn) and a nonstructural protein (NSm), while the S RNA segment encodes a nucleocapsid protein (N) and, in an alternative overlapping reading frame, a second nonstructural protein (NSs). [15] The genomic RNA segments are encapsidated by copies of the N protein in the form of ribonucleoprotein (RNP) complexes. [16] The N protein is the most abundant protein in virus particles and infected cells and, therefore, the main target in many serological and molecular diagnostics. [17] [18]

Signs of disease

(A) Phylogenetic relationship between Schmallenberg virus and orthobunyaviruses of the Simbu, Bunyamwera, and California serogroups. (B) Detection of Schmallenberg virus genome in the blood of experimentally infected calves. Schmallenberg virus (phylogenetic).jpg
(A) Phylogenetic relationship between Schmallenberg virus and orthobunyaviruses of the Simbu, Bunyamwera, and California serogroups. (B) Detection of Schmallenberg virus genome in the blood of experimentally infected calves.

The virus causes two different profiles of Schmallenberg:

These disease signs have occurred during the period when the disease vectors (mosquitos, sandflies, midges) are active, during the summer and autumn of 2011, mainly affecting cattle.

Congenital malformations in newborn sheep, goats and calves are the most obvious symptoms. In many cases, the dam (female parent) apparently has not presented signs of illness. These cases have occurred from December 2011, especially in sheep. The major malformations observed were: scoliosis, hydrocephalus, arthrogryposis, hypoplasia of the cerebellum and an enlarged thymus. [19]

Diagnosis

Blood samples from live animals with suspicious symptoms are taken for analysis. Dead or aborted foetuses suspected of having the virus are sampled by taking a piece of the brain or spleen for analysis. The samples are tested with the RT-PCR for Schmallenberg virus that has been developed by the Friedrich-Loeffler Institute in Germany. [19] A commercial kit is now available from AdiaVet [20] which targets the L region of the tripartite ssRNA genome of the virus. [21]

Cases in the United Kingdom

Distribution of Schmallenberg virus by country in Europe Schmallenberg distribution map.png
Distribution of Schmallenberg virus by country in Europe

The disease was confirmed as present in the UK on 22 January 2012, on being formally identified in four sheep farms in Norfolk, Suffolk and East Sussex. [5] By 27 February 2012, the disease was reported in other counties in the south of England including the Isle of Wight, Wiltshire, West Berkshire, Gloucestershire, Hampshire and Cornwall. [22] It is likely that it was carried to Eastern England by midges from mainland Europe, [5] a possibility previously identified as a risk by Defra. [5]

Import bans

Russia, Ukraine, Kazakhstan, Egypt and Mexico have all suspended imports of live cattle and sheep, along with embryos and semen from affected countries. [23]

United States banned the import of bovine germplasm collected in EU countries after 1 June 2011. [24]

Related Research Articles

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<span class="mw-page-title-main">Rift Valley fever</span> Human and livestock viral disease

Rift Valley fever (RVF) is a viral disease of humans and livestock that can cause mild to severe symptoms. The mild symptoms may include: fever, muscle pains, and headaches which often last for up to a week. The severe symptoms may include: loss of sight beginning three weeks after the infection, infections of the brain causing severe headaches and confusion, and bleeding together with liver problems which may occur within the first few days. Those who have bleeding have a chance of death as high as 50%.

<i>Paramyxoviridae</i> Family of viruses

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<span class="mw-page-title-main">Coronavirus</span> Subfamily of viruses in the family Coronaviridae

Coronaviruses are a group of related RNA viruses that cause diseases in mammals and birds. In humans and birds, they cause respiratory tract infections that can range from mild to lethal. Mild illnesses in humans include some cases of the common cold, while more lethal varieties can cause SARS, MERS and COVID-19. In cows and pigs they cause diarrhea, while in mice they cause hepatitis and encephalomyelitis.

<i>Bunyavirales</i> Order of RNA viruses

Bunyavirales is an order of segmented negative-strand RNA viruses with mainly tripartite genomes. Member viruses infect arthropods, plants, protozoans, and vertebrates. It is the only order in the class Ellioviricetes. The name Bunyavirales derives from Bunyamwera, where the original type species Bunyamwera orthobunyavirus was first discovered. Ellioviricetes is named in honor of late virologist Richard M. Elliott for his early work on bunyaviruses.

Bwamba orthobunyavirus (BWAV) belongs to the genus Orthobunyavirus and the order Bunyavirales RNA viruses. BWAV is present in large parts of Africa, endemic in Mozambique, Tanzania and Uganda. It is transmitted to humans through mosquito bites and results in a brief benign generalised infection with headache, skin rash, diarrhea and joint pain and lasts 4–5 days. The animal reservoir of the virus includes birds, monkeys and donkeys.

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<i>Orbivirus</i> Genus of viruses

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<i>Akabane orthobunyavirus</i> Species of virus

Akabane virus is an insect-transmitted virus that causes congenital abnormalities of the central nervous systems in ruminants. The virus is found in Australia, where it is most commonly spread by biting midges of the Culicoides species.

<span class="mw-page-title-main">Double-stranded RNA viruses</span> Type of virus according to Baltimore classification

Double-stranded RNA viruses are a polyphyletic group of viruses that have double-stranded genomes made of ribonucleic acid. The double-stranded genome is used as a template by the viral RNA-dependent RNA polymerase (RdRp) to transcribe a positive-strand RNA functioning as messenger RNA (mRNA) for the host cell's ribosomes, which translate it into viral proteins. The positive-strand RNA can also be replicated by the RdRp to create a new double-stranded viral genome.

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References

  1. 1 2 3 4 Kai Kupferschmidt (13 January 2012). "New animal virus takes northern Europe by surprise". Science. Archived from the original on 15 January 2012. Retrieved 16 January 2012.
  2. ↑ Richard Black (7 August 2012). "Schmallenberg virus 'may spread across UK'". BBC News . Retrieved 7 August 2012.
  3. ↑ Goller KV, Höper D, Schirrmeier H, Mettenleiter TC, Beer M (October 2012). "Schmallenberg virus as possible ancestor of Shamonda virus". Emerg Infect Dis. 18 (10): 1644–1646. doi:10.3201/eid1810.120835. PMC   3471646 . PMID   23017842.
  4. ↑ Dongyou Liu: Molecular Detection of Animal Viral Pathogens, Schmallenberg virus, S. 563, CRC Press, 2016, ISBN   9781498700368
  5. 1 2 3 4 Damian Carrington (23 January 2012). "Schmallenberg virus confirmed on farms in the UK". The Guardian . Retrieved 23 January 2012.
  6. ↑ Regula Kennel (20 July 2012). "Schmallenbergvirus auch in der Schweiz" [Schmallenberg virus also in Switzerland] (in German). Schweizerische Eidgenossenschaft . Retrieved 5 December 2013.
  7. ↑ "Schmallenberg virus confirmed in a bovine foetus in County Cork". Department of Agriculture, Food & the Marine. 30 October 2012. Retrieved 5 December 2013.
  8. ↑ Ulla Rikula (15 January 2013). "Schmallenberg virus found in deformed lambs". Finnish Food Safety Authority Evira . Retrieved 5 December 2013.
  9. ↑ Mette Buck Jensen (7 June 2012). "Schmallenberg virus påvist i danske husdyr for første gang". Danmarks Tekniske Universitet . Retrieved 5 December 2013.
  10. ↑ Erika Chenais (27 November 2012). "Nytt virus hos får och nötkreatur i Sverige". Statens veterinärmedicinska anstalt . Retrieved 5 December 2013.
  11. 1 2 3 4 5 6 Schmallenberg virus: new Orthobunyavirus in cattle Archived 28 January 2012 at the Wayback Machine , updated 10 January 2012, accessed 16 January 2012
  12. ↑ Risk assessment: New Orthobunyavirus isolated from infected cattle and small livestock ─ potential implications for human health, European Centre for Disease Prevention and Control, 22 December 2011, accessed 17 January 2012
  13. ↑ SMC(UK) Fact Sheet on Schmallenberg virus
  14. ↑ "FLI: First visualization of Schmallenberg virus". Archived from the original on 6 January 2013. Retrieved 18 March 2012.
  15. ↑ Alexander., Plyusnin; M., Elliott, Richard (1 January 2011). Bunyaviridae : molecular and cellular biology. Caister Academic Press. ISBN   9781904455905. OCLC   711044654.{{cite book}}: CS1 maint: multiple names: authors list (link)
  16. ↑ Ariza, A.; Tanner, S. J.; Walter, C. T.; Dent, K. C.; Shepherd, D. A.; Wu, W.; Matthews, S. V.; Hiscox, J. A.; Green, T. J. (1 June 2013). "Nucleocapsid protein structures from orthobunyaviruses reveal insight into ribonucleoprotein architecture and RNA polymerization". Nucleic Acids Research. 41 (11): 5912–5926. doi:10.1093/nar/gkt268. ISSN   0305-1048. PMC   3675483 . PMID   23595147.
  17. ↑ Bilk, S.; Schulze, C.; Fischer, M.; Beer, M.; Hlinak, A.; Hoffmann, B. (14 September 2012). "Organ distribution of Schmallenberg virus RNA in malformed newborns". Veterinary Microbiology. 159 (1–2): 236–238. doi:10.1016/j.vetmic.2012.03.035. PMID   22516190.
  18. ↑ Bréard, Emmanuel; Lara, Estelle; Comtet, Loïc; Viarouge, Cyril; Doceul, Virginie; Desprat, Alexandra; Vitour, Damien; Pozzi, Nathalie; Cay, Ann Brigitte (15 January 2013). "Validation of a Commercially Available Indirect Elisa Using a Nucleocapside Recombinant Protein for Detection of Schmallenberg Virus Antibodies". PLOS ONE. 8 (1): e53446. Bibcode:2013PLoSO...853446B. doi: 10.1371/journal.pone.0053446 . ISSN   1932-6203. PMC   3546048 . PMID   23335964.
  19. 1 2 "Programa nacional de vigilancia epidemiológica frente al virus de Schmallenberg" (PDF). Ministerio de Agricultura Alimentación y Medio Ambiente. 2 February 2012. Retrieved 8 February 2012.
  20. ↑ SBV - Schmallenberg Virus PCR Detectction Kit
  21. ↑ Genbank: Schmallenberg virus RdRp gene for RNA-dependent RNA polymerase, segment L, genomic RNA, isolate BH80/11-4
  22. ↑ "Schmallenberg livestock virus hits 74 farms in England". BBC News. 27 February 2012. Retrieved 5 December 2013.
  23. ↑ "Turkish cattle demand key amid Schmallenberg bans". Agra Informa. 9 March 2012. Retrieved 5 December 2013.
  24. ↑ "Schmallenberg Virus Restrictions for Imported Bovine Germplasm from the European Union (EU), or Countries Following EU Legislation". Animal and Plant Health Inspection Service. 12 September 2013. Retrieved 5 December 2013.
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