| Office | Name | Party | Term |
|---|
| Prime Minister | Amintore Fanfani | | DC | 2 July 1958–16 February 1959 |
| Deputy Prime Minister | Antonio Segni | | DC | 2 July 1958–16 February 1959 |
| Minister of Foreign Affairs | Antonio Segni (ad interim) | | DC | 2 July 1958–16 February 1959 |
| Minister of the Interior | Fernando Tambroni | | DC | 2 July 1958–16 February 1959 |
| Minister of Grace and Justice | Guido Gonella | | DC | 2 July 1958–16 February 1959 |
| Minister of Budget | Giuseppe Medici | | DC | 2 July 1958–16 February 1959 |
| Minister of Finance | Luigi Preti | | PSDI | 2 July 1958–16 February 1959 |
| Minister of Treasury | Giulio Andreotti | | DC | 2 July 1958–16 February 1959 |
| Minister of Defence | Antonio Segni | | DC | 2 July 1958–16 February 1959 |
| Minister of Public Education | Aldo Moro | | DC | 2 July 1958–16 February 1959 |
| Minister of Public Works | Giuseppe Togni | | DC | 2 July 1958–16 February 1959 |
| Minister of Agriculture and Forests | Mario Ferrari Aggradi | | DC | 2 July 1958–16 February 1959 |
| Minister of Transport | Armando Angelini | | DC | 2 July 1958–16 February 1959 |
| Minister of Post and Telecommunications | Alberto Simonini | | PSDI | 2 July 1958–16 February 1959 |
| Minister of Industry and Commerce | Giorgio Bo | | DC | 2 July 1958–16 February 1959 |
| Minister of Health | Vincenzo Monaldi | | DC | 2 July 1958–16 February 1959 |
| Minister of Foreign Trade | Emilio Colombo | | DC | 2 July 1958–16 February 1959 |
| Minister of Merchant Navy | Giuseppe Spataro | | DC | 2 July 1958–16 February 1959 |
| Minister of State Holdings | Edgardo Lami Starnuti | | PSDI | 2 July 1958–16 February 1959 |
| Minister of Labour and Social Security | Ezio Vigorelli | | PSDI | 2 July 1958–16 February 1959 |
| Minister for the Fund for the South (without portfolio) | Giulio Pastore | | DC | 2 July 1958–16 February 1959 |
| Minister for Parliamentary Relations (without portfolio) | Rinaldo Del Bo | | DC | 2 July 1958–16 February 1959 |
| Minister for Public Administration Reform (without portfolio) | Camillo Giardina | | DC | 2 July 1958–16 February 1959 |
|
| Secretary of the Council of Ministers | Antonio Maxia | | DC | 2 July 1958–16 February 1959 |