Creutzfeldt–Jakob disease (CJD), also known as subacute spongiform encephalopathy or neurocognitive disorder due to prion disease, is a fatal degenerative brain disorder. Early symptoms include memory problems, behavioral changes, poor coordination, and visual disturbances. Later symptoms include dementia, involuntary movements, blindness, weakness, and coma. About 70% of people die within a year of diagnosis. The name Creutzfeldt–Jakob disease was introduced by Walther Spielmeyer in 1922, after the German neurologists Hans Gerhard Creutzfeldt and Alfons Maria Jakob.
Transmissible spongiform encephalopathies (TSEs) also known as prion diseases, are a group of progressive, incurable, and fatal conditions that are associated with prions and affect the brain and nervous system of many animals, including humans, cattle, and sheep. According to the most widespread hypothesis, they are transmitted by prions, though some other data suggest an involvement of a Spiroplasma infection. Mental and physical abilities deteriorate and many tiny holes appear in the cortex causing it to appear like a sponge when brain tissue obtained at autopsy is examined under a microscope. The disorders cause impairment of brain function, including memory changes, personality changes and problems with movement that worsen chronically.
The Medical Research Council (MRC) is responsible for co-coordinating and funding medical research in the United Kingdom. It is part of United Kingdom Research and Innovation (UKRI), which came into operation 1 April 2018, and brings together the UK's seven research councils, Innovate UK and Research England. UK Research and Innovation is answerable to, although politically independent from, the Department for Business, Energy and Industrial Strategy.
Robert Evan Kendell, was a British psychiatrist. He was Chief Medical Officer of Scotland from 1991 to 1996 and President of the Royal College of Psychiatrists from 1996 to 1999.
Sir David John Spiegelhalter is a British statistician and a Fellow of Churchill College, Cambridge. From 2007 to 2018 he was Winton Professor of the Public Understanding of Risk in the Statistical Laboratory at the University of Cambridge. Spiegelhalter is an ISI highly cited researcher.
John Mark Purdey was an English organic farmer who came to public attention in the 1980s, when he began to circulate his own theories regarding the causes of bovine spongiform encephalopathy.
Variant Creutzfeldt–Jakob disease (vCJD), commonly referred to as "mad cow disease" or "human mad cow disease" to distinguish it from its BSE counterpart, is a fatal type of brain disease within the transmissible spongiform encephalopathy family. Initial symptoms include psychiatric problems, behavioral changes, and painful sensations. In the later stages of the illness, patients may exhibit poor coordination, dementia and involuntary movements. The length of time between exposure and the development of symptoms is unclear, but is believed to be years to decades. Average life expectancy following the onset of symptoms is 13 months.
Sylvia Therese Richardson is a French/British Bayesian statistician and is currently Professor of Biostatistics and Director of the MRC Biostatistics Unit at the University of Cambridge. In 2021 she became the president of the Royal Statistical Society for the 2021–22 year.
Peter George Smith CBE BSc DSc HonMFPHM FMedSci, is an eminent epidemiologist and Professor of Tropical Epidemiology at the London School of Hygiene and Tropical Medicine (LSHTM).
Bovine spongiform encephalopathy (BSE), commonly known as mad cow disease, is an incurable and invariably fatal neurodegenerative disease of cattle. Symptoms include abnormal behavior, trouble walking, and weight loss. Later in the course of the disease, the cow becomes unable to function normally. There is conflicting information about the time between infection and onset of symptoms. In 2002, the World Health Organization (WHO) suggested it to be approximately four to five years. Time from onset of symptoms to death is generally weeks to months. Spread to humans is believed to result in variant Creutzfeldt–Jakob disease (vCJD). As of 2018, a total of 231 cases of vCJD had been reported globally.
Meat on the bone or bone-in meat is meat that is sold with some or all of the bones included in the cut or portion, i.e. meat that has not been filleted. The phrase "on the bone" can also be applied to specific types of meat, most commonly ham on the bone, and to fish. Meat or fish on the bone may be cooked and served with the bones still included or the bones may be removed at some stage in the preparation.
The National Prion Clinic (UK) is part of the University College London Hospitals NHS Foundation Trust. Its aim is to diagnose and treat patients with any form of human prion disease (Creutzfeldt-Jakob disease, CJD). In addition, the clinic facilitates research in diagnostics and therapeutics, organises clinical trials, and counsels those with an increased genetic risk of the disease.
Malcolm Andrew Ferguson-Smith, is a British geneticist.
Ian Ford [ FRSE FRCP(Glas) FSCT ] is a professor of biostatistics and a director of the Robertson Centre for Biostatistics, and a former Dean of Faculty of Information and Mathematical Sciences, at the University of Glasgow.
Rosalind Ridley is a British psychologist and researcher who was head of the Medical Research Council Comparative Cognition Research Team in the Department of Psychology, Cambridge, UK, until 2005. She was a fellow of Newnham College, Cambridge from 1995–2010 and Vice-Principal from 2000–2005. She holds the privileges of a Fellow Emerita at Newnham College.
Christl Ann Donnelly is a professor of statistical epidemiology at Imperial College London, the University of Oxford and a Fellow of St Peter's College, Oxford. She serves as associate director of the MRC Centre for Global Infectious Disease Analysis.
Azra Catherine Hilary Ghani is a British epidemiologist who is a professor of Infectious Disease Epidemiology at Imperial College London. Her research considers the mathematical modelling of infectious diseases, including malaria, bovine spongiform encephalopathy and coronavirus. She has worked with the World Health Organization on their technical strategy for malaria. She is associate director of the MRC Centre for Global Infectious Disease Analysis.
The Beef Bones Regulations 1997 was a statutory instrument of the British government that limited the sale of beef on the bone. The regulations were implemented as a response to the United Kingdom BSE outbreak over fears that variant Creutzfeldt–Jakob disease in humans might be caused by the consumption of dorsal root ganglia, which lie near the bone. As well as beef on the bone, all beef-bone derived products were prohibited from sale. This had the effect of outlawing T-bone steaks, prime ribs and oxtail as well as some soups and stocks. Other aspects of the regulations dealt with the deboning of beef and the keeping of records in the food production industry. The restrictions on sales were lifted in December 1999 and the regulations as a whole were revoked in April 2008.
Linda Sharples is a British statistician who is Professor of Medical Statistics at the London School of Hygiene & Tropical Medicine. Her research considers statistical analysis of medical interventions. She has provided expert advice to clinical trials on cardiovascular disease, diabetes and cancer.
Daniela De Angelis is an Italian biostatistician in the area of infectious disease modelling. Her current roles are Professor of Statistical Science for Health at the University of Cambridge in the Department of Primary Care and Public Health and Deputy Director and Programme Leader at the Medical Research Council Biostatistics Unit. She has published research on the development and application of statistical methods to monitor infectious diseases such as SARS COVID-19, influenza, HIV and hepatitis C. Daniela is member of scientific advisory groups such as NICE, WHO, and UNAIDS. She is a member of SPI-M and the Royal Statistical Society Task Force for COVID-19
