Sialidase-4

NEU4
Identifiers
Aliases	NEU4 , neuraminidase 4
External IDs	OMIM: 608527 MGI: 2661364 HomoloGene: 15433 GeneCards: NEU4
Gene location (Human) Chr. Chromosome 2 (human) [1] Band 2q37.3 Start 241,809,065 bp [1] End 241,817,413 bp [1]
Gene location (Mouse) Chr. Chromosome 1 (mouse) [2] Band 1|1 D Start 93,948,173 bp [2] End 93,956,056 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right lobe of liver substantia nigra duodenum temporal lobe amygdala hippocampus proper hypothalamus putamen nucleus accumbens caudate nucleus Top expressed in hypothalamus superior frontal gyrus cerebellar cortex hippocampus proper olfactory bulb More reference expression data BioGPS n/a
Gene ontology Molecular function exo-alpha-(2->6)-sialidase activity exo-alpha-(2->8)-sialidase activity hydrolase activity, acting on glycosyl bonds protein binding exo-alpha-(2->3)-sialidase activity hydrolase activity exo-alpha-sialidase activity Cellular component organelle inner membrane membrane lysosomal lumen lysosome cytoplasm intracellular membrane-bounded organelle Biological process glycosphingolipid metabolic process lipid metabolism lipid catabolic process glycoprotein catabolic process oligosaccharide catabolic process metabolism ganglioside catabolic process carbohydrate metabolic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 129807 241159 Ensembl ENSG00000204099 ENSG00000277926 ENSMUSG00000034000 UniProt Q8WWR8 Q8BZL1 RefSeq (mRNA) NM_080741 NM_001167599 NM_001167600 NM_001167601 NM_001167602 NM_173772 NM_001310769 RefSeq (protein) NP_001161071 NP_001161072 NP_001161073 NP_001161074 NP_542779 NP_001161071.1 NP_001161072.1 NP_001161073.1 NP_001161074.1 NP_001297698 NP_776133 Location (UCSC) Chr 2: 241.81 – 241.82 Mb Chr 1: 93.95 – 93.96 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Sialidase-4 is an enzyme that in humans is encoded by the NEU4 gene. ^[5]

Function

This gene belongs to a family of glycohydrolytic enzymes which remove sialic acid residues from glycoproteins and glycolipids. ^[5]

Interactions

Sialidase-4 has been shown to interact with phospholipid scramblase 1. ^[6]

References

1. ENSG00000277926 GRCh38: Ensembl release 89: ENSG00000204099, ENSG00000277926 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000034000 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: NEU4 sialidase 4".
6. Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (Oct 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature . 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID   16189514. S2CID   4427026.

Further reading

• Comelli EM, Amado M, Lustig SR, Paulson JC (2004). "Identification and expression of Neu4, a novel murine sialidase". Gene. 321: 155–61. doi:10.1016/j.gene.2003.08.005. PMID   14637003.
• Monti E, Bassi MT, Bresciani R, Civini S, Croci GL, Papini N, Riboni M, Zanchetti G, Ballabio A, Preti A, Tettamanti G, Venerando B, Borsani G (2004). "Molecular cloning and characterization of NEU4, the fourth member of the human sialidase gene family". Genomics. 83 (3): 445–53. doi:10.1016/j.ygeno.2003.08.019. PMID   14962670.
• Seyrantepe V, Landry K, Trudel S, Hassan JA, Morales CR, Pshezhetsky AV (2004). "Neu4, a novel human lysosomal lumen sialidase, confers normal phenotype to sialidosis and galactosialidosis cells". J. Biol. Chem. 279 (35): 37021–9. doi: 10.1074/jbc.M404531200 . PMID   15213228.
• Wan D, Gong Y, Qin W, Zhang P, Li J, Wei L, Zhou X, Li H, Qiu X, Zhong F, He L, Yu J, Yao G, Jiang H, Qian L, Yu Y, Shu H, Chen X, Xu H, Guo M, Pan Z, Chen Y, Ge C, Yang S, Gu J (2004). "Large-scale cDNA transfection screening for genes related to cancer development and progression". Proc. Natl. Acad. Sci. U.S.A. 101 (44): 15724–9. Bibcode:2004PNAS..10115724W. doi: 10.1073/pnas.0404089101 . PMC   524842 . PMID   15498874.
• Stamatos NM, Liang F, Nan X, Landry K, Cross AS, Wang LX, Pshezhetsky AV (2005). "Differential expression of endogenous sialidases of human monocytes during cellular differentiation into macrophages". FEBS J. 272 (10): 2545–56. doi: 10.1111/j.1742-4658.2005.04679.x . PMID   15885103. S2CID   27379898.