U.S. Route 380 (US 380) is an east–west United States highway. The highway's eastern terminus is in Greenville, Texas at an intersection with Interstate 30, of which the easternmost 3–4 miles are concurrent with US 69 in a loop around the west and south sides of Greenville. Its western terminus is at San Antonio, New Mexico, south of Socorro at an intersection with Interstate 25. It intersected with its parent, U.S. Route 80, at Cisco until 1971, when it was rerouted along the former SH 24 from that highway's western terminus near Old Glory to Greenville. Former U.S. Route 380 from Cisco to near Old Glory became an extension of SH 6. The highway no longer connects to any x80 route. US 380 passes through some of the far northern suburbs of the Dallas/Fort Worth Metroplex, including Denton, Frisco, McKinney and Princeton. The portion in Texas from the New Mexico state line to Jayton was SH 84 before 1939. Its spur, SH 84A, went from Jayton to Aspermont, until 1930, when it became SH 161.
State Highway 121 is a state highway angling from southwest to northeast through north central Texas. It runs from Cleburne, Texas at US 67 to SH 78 in Bonham, Texas, just north of a junction with US 82.
State Highway 4, known locally as Boca Chica Boulevard, is an east–west state highway in the U.S. state of Texas that runs from the Gateway International Bridge in Brownsville to the Gulf of Mexico at Boca Chica Beach. Outside of Brownsville, it roughly parallels the Rio Grande. It is the southernmost Texas state highway.
State Highway 7 (SH 7) is an east–west state highway in the U.S. state of Texas that runs from Interstate 35 at Eddy to U.S. Highway 84 about 3 miles (4.8 km) west of the Louisiana state line. Between Crockett and Nacogdoches, SH 7 passes through the Davy Crockett National Forest. Commissioned on April 4, 1917, SH 7 is one of the original state highways established in Texas, and has been re-routed several times since its original conception. In earlier years, SH 7 mostly followed present day U.S. Highway 84, U.S. Highway 67, U.S. Highway 70 among other highways between northwest Texas and the Louisiana state line. By 1939, most of the mileage belonging to SH 7 was transferred to the U.S. Highway System, leaving the highway extant only within eastern Texas. SH 7 subsequently went through several other major reroutings, truncations and extensions between 1939 and 1990, before becoming the highway it is today.
State Highway 16 is a south–north state highway in the U.S. state of Texas that runs from Zapata on the boundary with Mexico to U.S. Highway 281 24 miles (39 km) south of Wichita Falls. It is the longest state highway in Texas at almost 542 miles (872 km), but is only the ninth-longest of any highway classification in the state.
State Highway 18 is a state highway in the U.S. state of Texas maintained by the Texas Department of Transportation (TxDOT) that runs from Fort Stockton in western Texas to the New Mexico state line between Kermit and Jal, New Mexico. This route was designated in 1958 over the northern half of what was previously SH 82.
State Highway 114 is a state highway that runs from the Dallas-Fort Worth Metroplex westward across Texas to the New Mexico state line, where it becomes New Mexico State Road 114, which eventually ends at Elida, New Mexico at US 70 / NM 330.
State Highway 48 runs from Brownsville to Port Isabel in Deep South Texas.
State Highway 70 is a state highway in Texas. The route runs approximately 315 miles (507 km) from US 277 near Blackwell to US 83 south of Perryton.
State Highway 100 is a Texas state highway that runs 24 miles (39 km) between "Russeltown" and Port Isabel. It was designated in 1926 along its current route. Its western terminus is at Interstate 69E/U.S. Highway 77/83 and ends at the western end of the Queen Isabella Memorial Causeway at Port Isabel. The route continues as Texas Park Road 100 east and north to a dead end on South Padre Island.
State Highway 364 is a south–north state highway that runs from Interstate 2/U.S. Highway 83 northward to Farm to Market Road 2221 in western Hidalgo County. The route was designated in 2001, replacing Farm to Market Road 2894.
State Highway 495 is a state highway in the U.S. state of Texas that runs between Mission and Alamo in Deep South Texas. This route was designated in 2001, replacing Farm to Market Road 495. This route runs parallel to US 83 for its entire route. In McAllen, the route is also known as Pecan Blvd.
State Highway 256 is a state highway that runs from Silverton in northern Texas east to a junction with US 83 near Wellington, close to the Oklahoma state line.
State Highway 336 is a 14.506-mile (23.345 km) state highway in the U.S. state of Texas. The highway begins at a junction with Spur 241 in Hidalgo and heads north to a junction with State Highway 107 in Edinburg.
Interstate 69 (I-69) is an Interstate Highway that is in the process of being built in the U.S. state of Texas. It is part of a longer I-69 extension known as the NAFTA superhighway, that, when completed, will connect Canada to Mexico. In Texas, it will connect Tenaha and the Louisiana segment of the route through the eastern part of the state and along the Texas Gulf Coast to Victoria, where it will split into three branches: I-69E to Brownsville, I-69C to Pharr, and I-69W to Laredo. The first segment of I-69 in Texas was opened in 2011 near Corpus Christi. The American Association of State Highway and Transportation Officials (AASHTO) approved an additional 58 miles (93 km) of U.S. Highway 77 (US 77) from Brownsville to the Willacy–Kenedy county line for designation as I-69, which was to be signed as I-69E upon concurrence from the Federal Highway Administration (FHWA). FHWA approval for this segment was announced on May 29, 2013. By March 2015, a 74.9-mile (120.5 km) section of US 59 had been completed and designated as I-69 through Greater Houston. As of 2024, short segments near the southern terminuses of the three branch routes have also all been completed. These branches are planned to be connected to the rest of the Interstate Highway System.
Farm to Market Road 50 is a Farm to Market Road in the U.S. state of Texas maintained by the Texas Department of Transportation (TxDOT). The 52.9-mile (85.1 km) route begins at State Highway 105 near Brenham and passes to the north through Independence to U.S. Route 79 and U.S. Route 190 near Hearne. The road has a brief concurrency with SH 21 along a bridge crossing the Brazos River. The road is in Washington, Burleson, Brazos, and Robertson counties.
I-2 / US 83 in Mission 
SH 495 in Mission
SH 336 in McAllen 
I-69C / US 281 in Edinburg 
I-69E / US 77 in Combes 
