Thunberginol A

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Thunberginol A
Thunberginol A.svg
Names
IUPAC name
3-(3,4-dihydroxyphenyl)-8-hydroxyisochromen-1-one
Identifiers
3D model (JSmol)
ChemSpider
PubChem CID
Properties
C15H10O5
Molar mass 270.240 g·mol−1
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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Infobox references

Thunberginol A is an isocoumarin found in Hydrangea macrophylla [1] and the herbal preparation hydrangeae dulcis folium which is produced from its leaves. [2] [3]

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<i>Hydrangea</i> genus of flowering plants in the family Hydrangeaceae

Hydrangea is a genus of 70–75 species of flowering plants native to Asia and the Americas. By far the greatest species diversity is in eastern Asia, notably Korea, China, and Japan. Most are shrubs 1 to 3 meters tall, but some are small trees, and others lianas reaching up to 30 m (98 ft) by climbing up trees. They can be either deciduous or evergreen, though the widely cultivated temperate species are all deciduous.

<i>Hydrangea macrophylla</i> species of plant

Hydrangea macrophylla is a species of flowering plant in the family Hydrangeaceae, native to Japan. It is a deciduous shrub growing to 2 m (7 ft) tall by 2.5 m (8 ft) broad with large heads of pink or blue flowers in summer and autumn. Common names include bigleaf hydrangea, French hydrangea, lacecap hydrangea, mophead hydrangea, penny mac and hortensia. It is widely cultivated in many parts of the world in many climates. It is not to be confused with H. aspera 'Macrophylla'.

<i>Hydrangea quercifolia</i> species of plant

Hydrangea quercifolia, commonly known by its translation oakleaf hydrangea or oak-leaved hydrangea, is a species of flowering plant native to the Southeastern United States, in woodland habitats from North Carolina west to Tennessee, and south to Florida and Louisiana. A deciduous shrub with white showy flower heads, it is a commonly grown garden plant. Numerous cultivars are available commercially.

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Hydrangenol chemical compound

Hydrangenol is a dihydroisocoumarin. It can be found in Hydrangea macrophylla, as well as its 8-O-glucoside. (-)-hydrangenol 4'-O-glucoside and (+)-hydrangenol 4'-O-glucoside can be found in Hydrangeae Dulcis Folium, the processed leaves of H. macrophylla var. thunbergii.

Phyllodulcin chemical compound

Phyllodulcin is a dihydroisocoumarin found in Hydrangea macrophylla and Hydrangea serrata. It is a sweetener 400-800 sweeter than sugar.

Thunberginol B chemical compound

Thunberginol B is an isocoumarin found in Hydrangeae Dulcis Folium, the processed leaves of Hydrangea macrophylla var. thunbergii.

Thunberginol C chemical compound

Thunberginol C is a dihydroisocoumarin found in Hydrangeae Dulcis Folium, the processed leaves of Hydrangea macrophylla var. thunbergii.

Thunberginol D chemical compound

Thunberginol D is a dihydroisocoumarin found in Hydrangeae Dulcis Folium, the processed leaves of Hydrangea macrophylla var. thunbergii.

Thunberginol E chemical compound

Thunberginol E is a dihydroisocoumarin found in Hydrangeae Dulcis Folium, the processed leaves of Hydrangea macrophylla var. thunbergii.

Thunberginol F chemical compound

Thunberginol F is a phthalide found in Hydrangea macrophylla.

Thunberginol G chemical compound

Thunberginol G is a dihydroisocoumarin found in Hydrangeae Dulcis Folium, the processed leaves of Hydrangea macrophylla var. thunbergii.

MGS-0039 chemical compound

MGS-0039 is a drug that is used in neuroscientific research, which acts as a potent and selective antagonist for group II of the metabotropic glutamate receptors (mGluR2/3). It produces antidepressant and anxiolytic effects in animal studies, and has been shown to boost release of dopamine and serotonin in specific brain areas. Research has suggested this may occur through a similar mechanism as that suggested for the similarly glutamatergic drug ketamine.

Hydrangeic acid chemical compound

Hydrangeic acid is a stilbenoid found in the leaves of Hydrangea macrophylla.

References

  1. Matsuda, H.; Shimoda, H.; Yamahara, J.; Yoshikawa, M. (1999). "Effects of phyllodulcin, hydrangenol, and their 8-O-glucosides, and thunberginols a and F from Hydrangea macrophylla SERINGE var. Thunbergii MAKINO on passive cutaneous anaphylaxis reaction in rats". Biological & Pharmaceutical Bulletin. 22 (8): 870–872. doi: 10.1248/bpb.22.870 . PMID   10480329. INIST:1959604.
  2. Yamahara, J.; Matsuda, H.; Shimoda, H.; Wariishi, N.; Yagi, N.; Murakami, N.; Yoshikawa, M. (1995). "Effects of thunberginol a contained in Hydrangeae dulcis forium on types I-IV allergies". Nihon yakurigaku zasshi. Folia pharmacologica Japonica (in Japanese). 105 (5): 365–379. PMID   7628785.
  3. Matsuda, H.; Shimoda, H.; Yamahara, J.; Yoshikawa, M. (1998). "Immunomodulatory activity of thunberginol a and related compounds isolated from hydrangeae dulcis folium on splenocyte proliferation activated by mitogens". Bioorganic & Medicinal Chemistry Letters. 8 (3): 215. doi:10.1016/S0960-894X(97)10221-9.