Thunberginol A

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Thunberginol A
Thunberginol A.svg
Names
IUPAC name
3-(3,4-dihydroxyphenyl)-8-hydroxyisochromen-1-one
Identifiers
3D model (JSmol)
ChemSpider
PubChem CID
Properties
C15H10O5
Molar mass 270.240 g·mol−1
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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Infobox references

Thunberginol A is an isocoumarin found in Hydrangea macrophylla [1] and the herbal preparation hydrangeae dulcis folium which is produced from its leaves. [2] [3]

Related Research Articles

<i>Hydrangea</i> genus of flowering plants in the family Hydrangeaceae

Hydrangea common names hydrangea or hortensia, is a genus of 70–75 species of flowering plants native to Asia and the Americas. By far the greatest species diversity is in eastern Asia, notably Korea, China, and Japan. Most are shrubs 1 to 3 meters tall, but some are small trees, and others lianas reaching up to 30 m (98 ft) by climbing up trees. They can be either deciduous or evergreen, though the widely cultivated temperate species are all deciduous.

<i>Hydrangea macrophylla</i> Species of flowering plant in the family Hydrangeaceae

Hydrangea macrophylla is a species of flowering plant in the family Hydrangeaceae, native to Japan. It is a deciduous shrub growing to 2 m (7 ft) tall by 2.5 m (8 ft) broad with large heads of pink or blue flowers in summer and autumn. Common names include bigleaf hydrangea, French hydrangea, lacecap hydrangea, mophead hydrangea, penny mac and hortensia. It is widely cultivated in many parts of the world in many climates. It is not to be confused with H. aspera 'Macrophylla'.

<i>Hydrangea quercifolia</i> Species of flowering plant in the family Hydrangeaceae

Hydrangea quercifolia, commonly known by its translation oakleaf hydrangea or oak-leaved hydrangea, is a species of flowering plant in the family Hydrangeaceae. It is native to the Southeastern United States, in woodland habitats from North Carolina west to Tennessee, and south to Florida and Louisiana. A deciduous shrub with white showy flower heads, it is a commonly grown garden plant. Numerous cultivars are available commercially.

Umbelliferone

Umbelliferone, also known as 7-hydroxycoumarin, hydrangine, skimmetine, and beta-umbelliferone, is a natural product of the coumarin family.

PRKACB

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GPR177

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<i>Bassia scoparia</i>

Bassia scoparia is a large annual herb in the family Amaranthaceae native to Eurasia. It has been introduced to many parts of North America, where it is found in grassland, prairie, and desert shrub ecosystems. Its common names include burningbush, ragweed, summer cypress, mock-cypress, kochia, belvedere, Mexican firebrush, and Mexican fireweed.

Metalloanthocyanin

A metalloanthocyanin is a chemical complex giving color to petals of certain plants.

Osemozotan (MKC-242) is a selective 5-HT1A receptor agonist with some functional selectivity, acting as a full agonist at presynaptic and a partial agonist at postsynaptic 5-HT1A receptors. 5-HT1A receptor stimulation influences the release of various neurotransmitters including serotonin, dopamine, norepinephrine, and acetylcholine. 5-HT1A receptors are inhibitory G protein-coupled receptor. Osemozotan has antidepressant, anxiolytic, antiobsessional, serenic, and analgesic effects in animal studies, and is used to investigate the role of 5-HT1A receptors in modulating the release of dopamine and serotonin in the brain, and their involvement in addiction to abused stimulants such as cocaine and methamphetamine.

Matrine

Matrine is an alkaloid found in plants from the genus Sophora. It has a variety of pharmacological effects, including anti-cancer effects, as well as κ-opioid and μ-opioid receptor agonism.

Hydrangenol

Hydrangenol is a dihydroisocoumarin. It can be found in Hydrangea macrophylla, as well as its 8-O-glucoside. (-)-hydrangenol 4'-O-glucoside and (+)-hydrangenol 4'-O-glucoside can be found in Hydrangeae Dulcis Folium, the processed leaves of H. macrophylla var. thunbergii.

Phyllodulcin

Phyllodulcin is a dihydroisocoumarin found in Hydrangea macrophylla and Hydrangea serrata. It is a sweetener 400-800 times sweeter than sugar.

Thunberginol B

Thunberginol B is an isocoumarin found in Hydrangeae Dulcis Folium, the processed leaves of Hydrangea macrophylla var. thunbergii.

Thunberginol C

Thunberginol C is a dihydroisocoumarin found in Hydrangeae Dulcis Folium, the processed leaves of Hydrangea macrophylla var. thunbergii.

Thunberginol D

Thunberginol D is a dihydroisocoumarin found in Hydrangeae Dulcis Folium, the processed leaves of Hydrangea macrophylla var. thunbergii.

Thunberginol E

Thunberginol E is a dihydroisocoumarin found in Hydrangeae Dulcis Folium, the processed leaves of Hydrangea macrophylla var. thunbergii.

Thunberginol F

Thunberginol F is a phthalide found in Hydrangea macrophylla.

Thunberginol G

Thunberginol G is a dihydroisocoumarin found in Hydrangeae Dulcis Folium, the processed leaves of Hydrangea macrophylla var. thunbergii.

Hydrangeic acid

Hydrangeic acid is a stilbenoid found in the leaves of Hydrangea macrophylla.

References

  1. Matsuda, H.; Shimoda, H.; Yamahara, J.; Yoshikawa, M. (1999). "Effects of phyllodulcin, hydrangenol, and their 8-O-glucosides, and thunberginols a and F from Hydrangea macrophylla SERINGE var. Thunbergii MAKINO on passive cutaneous anaphylaxis reaction in rats". Biological & Pharmaceutical Bulletin. 22 (8): 870–872. doi: 10.1248/bpb.22.870 . PMID   10480329. INIST:1959604.
  2. Yamahara, J.; Matsuda, H.; Shimoda, H.; Wariishi, N.; Yagi, N.; Murakami, N.; Yoshikawa, M. (1995). "Effects of thunberginol a contained in Hydrangeae dulcis forium on types I-IV allergies". Nihon Yakurigaku Zasshi. Folia Pharmacologica Japonica (in Japanese). 105 (5): 365–379. doi: 10.1254/fpj.105.365 . PMID   7628785.
  3. Matsuda, H.; Shimoda, H.; Yamahara, J.; Yoshikawa, M. (1998). "Immunomodulatory activity of thunberginol a and related compounds isolated from hydrangeae dulcis folium on splenocyte proliferation activated by mitogens". Bioorganic & Medicinal Chemistry Letters. 8 (3): 215–20. doi:10.1016/S0960-894X(97)10221-9. PMID   9871657.