Traditional serrated adenoma

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Traditional serrated adenomas
Traditional serrated adenoma intermed mag.jpg
Traditional serrated adenoma with intermediate magnification, showing serrated crypts and cytologic atypia (H&E stain).
Specialty Gastroenterology
Symptoms Asymptomatic
Complications Colorectal cancer
Usual onset>50 years of age
Diagnostic method Colonoscopy
Treatment Polypectomy
Frequency<1% of all colon polyps

Traditional serrated adenoma is a premalignant type of polyp found in the colon, often in the distal colon (sigmoid, rectum). Traditional serrated adenomas are a type of serrated polyp, and may occur sporadically or as a part of serrated polyposis syndrome. Traditional serrated adenomas are relatively rare, accounting for less than 1% of all colon polyps. [1] [2] Usually, traditional serrated adenomas are found in the distal colon and are usually less than 10 mm in size. [1]

Contents

Histopathology

Traditional serrated adenomas are characterized by ectopic crypts, pseudostratification, and a villous pattern with stretched nuclei. [3]

Epidemiology

Usually found in individuals over the age of 50 years, traditional serrated adenomas affect men and women equally. [1] The overall prevalence of traditional serrated adenomas is less than 1% of the general population. [3] Traditional serrated adenomas are the least common type of serrated polyps found in the colon, accounting for 5% of serrated colon polyps. [4]

References

  1. 1 2 3 McCarthy, AJ; Serra, S; Chetty, R (2019). "Traditional serrated adenoma: an overview of pathology and emphasis on molecular pathogenesis". BMJ Open Gastroenterology. 6 (1) e000317. doi:10.1136/bmjgast-2019-000317. PMC   6673762 . PMID   31413858.
  2. ↑ Kalimuthu, Sangeetha N.; Chelliah, Adeline; Chetty, Runjan (15 December 2016). "From traditional serrated adenoma to tubulovillous adenoma and beyond". World Journal of Gastrointestinal Oncology. 8 (12): 805–809. doi: 10.4251/wjgo.v8.i12.805 . ISSN   1948-5204. PMC   5156846 . PMID   28035250.
  3. 1 2 Crockett, SD; Nagtegaal, ID (October 2019). "Terminology, Molecular Features, Epidemiology, and Management of Serrated Colorectal Neoplasia". Gastroenterology. 157 (4): 949–966.e4. doi: 10.1053/j.gastro.2019.06.041 . PMID   31323292.
  4. ↑ Chetty, R (January 2016). "Traditional serrated adenoma (TSA): morphological questions, queries and quandaries". Journal of Clinical Pathology. 69 (1): 6–11. doi: 10.1136/jclinpath-2015-203452 . PMID   26553935. S2CID   12982470.
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