U.S. Route 22 (US 22) is a major west–east route and one of the original United States Numbered Highways, founded in 1926. It runs from Cincinnati, Ohio, at US 27, US 42, US 127, and US 52 to Newark, New Jersey, at US 1/9 at the Newark Airport Interchange.
U.S. Route 27 or U.S. Highway 27 (US 27) is a north–south United States Numbered Highway in the Southern and Midwestern U.S. The southern terminus is at US 1 in Miami, Florida. The northern terminus is at Interstate 69 (I-69) in Fort Wayne, Indiana. From Miami, it goes up the center of Florida, then west to Tallahassee, Florida, and north through such cities and towns as Columbus, Georgia; Rome, Georgia; Chattanooga, Tennessee; Lexington, Kentucky; Cincinnati, Ohio; Oxford, Ohio; Richmond, Indiana; and Fort Wayne, Indiana. It once extended north through Lansing, Michigan, to Cheboygan, Mackinaw City, and, for about three years, even as far as St. Ignace. US 27 was first signed in 1926, replacing what had been the eastern route of the Dixie Highway in many states.
U.S. Route 40 or U.S. Highway 40 (US 40), also known as the Main Street of America, is a major east–west United States Highway traveling across the United States from the Mountain States to the Mid-Atlantic States. As with most routes whose numbers end in a zero, US 40 once traversed the entire United States. It is one of the first U.S. Highways created in 1926 and its original termini were in San Francisco, California, and Atlantic City, New Jersey. US 40 currently ends at a junction with I-80 in Silver Summit, Utah, just outside Salt Lake City. West of this point US 40 was functionally replaced with I-80, and as these segments of I-80 were constructed the western portion of US 40 was truncated several times.
U.S. Route 52 (US 52) is a major United States highway in the central United States that extends from the northern to southeastern region of the United States. Contrary to most other even-numbered U.S. Highways, US 52 primarily follows a northwest–southeast route, and is signed north–south or east–west depending on the local orientation of the route. The highway's northwestern terminus is in Portal, North Dakota at the Canada–United States border, where it continues as Saskatchewan Highway 39. Its southeastern terminus is in Charleston, South Carolina, at Number 2 Meeting Street and White Point Garden along the Charleston Harbor.
U.S. Route 62 or U.S. Highway 62 (US 62) is an east–west United States Highway in the southern and northeastern United States. It runs from the Mexican border at El Paso, Texas, to Niagara Falls, New York, near the Canadian border. It is the only east–west United States Numbered Highway that connects Mexico and Canada. Parts of US 62 follow what once was the Ozark Trail, including the historic bridge across the South Canadian River in Newcastle, Oklahoma. This bridge was damaged beyond repair by the 2013 Moore tornado that struck Newcastle and Moore, Oklahoma. The highway runs north–south in New York and Pennsylvania.
U.S. Route 42 is an east–west United States highway that runs southwest–northeast for 350 miles (560 km) from Louisville, Kentucky to Cleveland, Ohio. The route has several names including Pearl Road from Cleveland to Medina in Northeast Ohio, Reading Road in Cincinnati, Cincinnati and Lebanon Pike in southwestern Ohio and Brownsboro Road in Louisville. Traveling northeast, the highway ends in downtown Cleveland and traveling southwest ends in Louisville.
U.S. Route 319 is a spur of US 19. It runs for 303 miles (488 km) from US 98 at the foot of the John Gorrie Memorial Bridge across from downtown Apalachicola, Florida to US 1/SR 4 in Wadley, Georgia, through the Panhandle of Florida and the southern portion of Georgia.
U.S. Route 231 (US 231) is a north–south U.S highway that is a parallel route of US 31. It runs for 912 miles (1,468 km) from St. John, Indiana, at US 41 to south of US 98 in downtown Panama City, Florida. One of its most notable landmarks is the William H. Natcher Bridge, a 0.853 miles (1.373 km) long cable-stayed bridge that connects Rockport, Indiana, to Owensboro, Kentucky, spanning the Ohio River.
U.S. Route 431 (US 431) is a spur of U.S. Route 31. It currently travels for approximately 556 miles (895 km) from US 231/Alabama State Route 210 and US 231 Business and US 431 Bus. in Dothan, Alabama, to Owensboro, Kentucky, at US 60 and Kentucky Route 2831. The major cities US 431 connects to are Dothan and Huntsville, Alabama, Franklin and Nashville, Tennessee, and Owensboro, Kentucky.
County Route 527 is a county highway in the U.S. state of New Jersey. The highway extends 84.86 mi (136.57 km) from Main Street in Toms River Township to Pompton Avenue in Cedar Grove. It passes through more counties (six) than any other county route in New Jersey. CR 527 is also the second longest 500-series county route in New Jersey after Route 519. The county route traverses through the northernmost stretches of the Pine Barrens in South Jersey, much of the Raritan Valley and Rahway Valley regions in Central Jersey, and the First and Second Watchung Mountains in North Jersey. It passes through Ocean, Monmouth, Middlesex, Somerset, Union, and Essex counties on the eastern side of the state.
State Route 37 (SR 37) is a 153.6-mile-long (247.2 km) state highway that travels west-to-east through portions of Clay, Calhoun, Baker, Mitchell, Colquitt, Cook, Berrien, Lanier, and Clinch counties in the southwestern and south-central parts of the U.S. state of Georgia. The highway connects the Alabama state line west of Fort Gaines to the Homerville area, via Newton, Camilla, Moultrie, Adel, and Lakeland. The highway actually serves as the eastern terminus of a long multi-state route that starts in Mississippi and goes through Alabama.
U.S. Route 50 runs east–west across the southern part of the state of Ohio, passing through Cincinnati, Chillicothe, and Athens. It is mainly a two-lane road except for the easternmost and westernmost parts. Near Athens it runs concurrently with State Route 32 (SR 32), a four-lane divided highway known as Corridor D, and from Coolville to the Ohio–West Virginia border it also overlaps SR 7 before crossing into Parkersburg, West Virginia.
U.S. Route 27 (US 27) in Kentucky runs 201.120 miles (323.671 km) from the Tennessee border to the Ohio border at Cincinnati. It crosses into the state in the Lake Cumberland area, passing near or through many small towns, including Somerset, Stanford, and Nicholasville. The road then passes straight through the heart of Lexington, including past the University of Kentucky (UK) and Transylvania University. North of Lexington, it passes through Cynthiana and Falmouth before entering Campbell County and passing through many Northern Kentucky suburbs before ending at the Ohio state line on the Taylor–Southgate Bridge in Cincinnati.
U.S. Route 6 (US 6) is a part of the United States Numbered Highway System that runs from Bishop, California, to Provincetown, Massachusetts. In Ohio, the road runs west–east from the Indiana state line near Edgerton to the Pennsylvania state line near Andover. The 248.002 miles (399.121 km) that lie in Ohio are maintained by the Ohio Department of Transportation (ODOT). US 6 serves the major cities of Sandusky, Lorain, and Cleveland. The highway is also called the Grand Army of the Republic Highway to honor the Union forces of the U.S. Civil War. The alternate name was designated in 1953.
US Highway 127 (US 127) is a part of the United States Numbered Highway System that runs from Chattanooga, Tennessee, to the Lower Peninsula of Michigan. In Ohio, the highway runs 194.27 miles (312.65 km) from the Ohio River in Cincinnati to the Michigan state line north of West Unity. US 127 runs south to north in Ohio's westernmost counties along the border of Indiana. The highway is a main route connecting many small towns, including eight county seats. The highway was first designated in 1926. Its route ended in downtown Toledo before being realigned to its current route in 1930.
U.S. Route 150 (US 150) in Kentucky is a 121.097-mile-long (194.887 km) east–west highway that runs from the Indiana state line above the Ohio River to US 25/KY 1249 at Mount Vernon.
U.S. Route 52 runs east–west across the southern part of the state of Ohio along the Ohio River, passing through or very near the cities and towns of Cincinnati, Portsmouth, and Ironton. For its first 19 miles (31 km) or so, the highway runs concurrently with Interstate 74 (I-74) and I-75 before it winds through downtown Cincinnati for several miles. The route is primarily two lanes between New Richmond and West Portsmouth, Ohio, where it becomes a four-lane partial access highway until it exits the state near Chesapeake.
U.S. Route 33 (US 33) is a United States Numbered Highway running from near Elkhart, Indiana, to Richmond, Virginia. Within the state of Ohio, it is a predominantly southeast–northwest highway running from west of Willshire before crossing over into West Virginia via the Ravenswood Bridge over the Ohio River. The route runs through largely rural territory throughout most of the state's west-central, central, and southeastern regions, although it also passes through large portions of downtown Columbus.
US 27 at Kentucky state line in Cincinnati 
