Interstate 27 (I-27) is an Interstate Highway, entirely in the US state of Texas, running north from Lubbock to I-40 in Amarillo. These two cities are the only control cities on I-27; other cities and towns served by I-27 include New Deal, Abernathy, Hale Center, Plainview, Kress, Tulia, Happy, and Canyon. In Amarillo, I-27 is commonly known as the Canyon Expressway, although it is also called Canyon Drive on its access roads. I-27 was officially designated the Marshall Formby Memorial Highway after former attorney and State Senator Marshall Formby in 2005. The entire length of I-27 replaced US Highway 87 (US 87) for through traffic. An extension of I-27 north to Raton, New Mexico, and south to Laredo, Texas was approved in 2022.
U.S. Highway 181 is a south–north U.S. Highway located entirely in the state of Texas. Both termini are at Interstate 37, the road that it mainly parallels to the east. US 181 begins in Corpus Christi, Texas at mile marker 0 to the south, through south-central Texas to just south of San Antonio to the north, for a total length of 137 miles (220 km).
U.S. Route 80 or U.S. Highway 80 (US 80) is a major east–west United States Numbered Highway in the Southern United States, much of which was once part of the early auto trail known as the Dixie Overland Highway. As the "0" in the route number indicates, it was originally a cross-country route, from the Pacific Ocean to the Atlantic Ocean. Its original western terminus was at Historic US 101 in San Diego, California. However, the entire segment west of Dallas, Texas, has been decommissioned in favor of various Interstate Highways and state highways. Currently, the highway's western terminus is at an interchange with Interstate 30 (I-30) on the Dallas–Mesquite city line. Its eastern terminus is in Tybee Island, Georgia near the Atlantic Ocean. Between Jonesville, Texas and Kewanee, Mississippi, US 80 runs parallel to or concurrently with Interstate 20. It also currently runs through Dallas, Texas; Shreveport, Louisiana; Jackson, Mississippi; Montgomery, Alabama; Columbus, Georgia; Macon, Georgia; and Savannah, Georgia.
U.S. Route 75 is a north–south U.S. Highway that runs 1,239 miles (1,994 km) in the central United States. The highway's northern terminus is located at the Canadian border near Noyes, Minnesota, at a now-closed border crossing. From this point, the highway once continued farther north as Manitoba Highway 75. Its southern terminus is located at Interstate 30 (I-30) and I-45 in Dallas, Texas, where US 75 is known as North Central Expressway.
U.S. Highway 96 (US 96) is a north–south United States Numbered Highway that runs for about 117.11 miles (188.47 km) entirely in the U.S state of Texas. Its number is a violation of the standard numbering convention, as even-numbered two-digit highways are east–west routes by rule. As of 2004, the highway's southern terminus is in Port Arthur at an intersection with State Highway 87 (SH 87). Its northern terminus is in Tenaha at an intersection with US 59 /(Future I-369) and US 84.
U.S. Route 290 is an east–west U.S. Highway located entirely within the state of Texas. Its western terminus is at Interstate 10 southeast of Segovia, and its eastern terminus is at Interstate 610 in northwest Houston. It is the main highway between Houston and Austin and is a cutoff for travelers wanting to bypass San Antonio on Interstate 10. Throughout its length west of Austin, US 290 cuts across mountainous hills comprising the Texas Hill Country and the Edwards Plateau; between Austin and Houston, the highway then travels through gradually hilly grasslands and pine forests comprising the Gulf Coastal Plains.
State Highway 6 (SH 6) runs from the Red River, the Texas–Oklahoma state line, to northwest of Galveston, where it is known as the Old Galveston Highway. In Sugar Land and Missouri City, it is known as Alvin-Sugarland Road and runs perpendicular to Interstate 69/U.S. Highway 59 (I-69/US 59). In the Houston area, it runs north to Farm to Market Road 1960 (FM 1960), then northwest along US 290 to Hempstead, and south to Westheimer Road and Addicks, and is known as Addicks Satsuma Road. In the Bryan–College Station area, it is known as the Earl Rudder Freeway. In Hearne, it is known as Market Street. In Calvert, it is known as Main Street. For most of its length, SH 6 is not a limited-access road. In 1997, the Texas Legislature designated SH 6 as the Texas Korean War Veterans Memorial Highway.
Loop 499 is a 7.868-mile-long (12.662 km) loop route around the city of Harlingen in the U.S. state of Texas. The loop extends around the northern, eastern, and southern sides, with Interstate 69E, U.S. Highway 77, and 83 completing the loop on the west side. This loop was proposed and temporarily designated in 1971 at the beginning of construction, with official designation in 1973. The loop is a significant thoroughfare around the city, as it is the main connection to Valley International Airport.
U.S. Highway 59 (US 59) in the U.S. state of Texas is named the Lloyd Bentsen Highway, after Lloyd Bentsen, former U.S. senator from Texas. In northern Houston, US 59, co-signed with Interstate 69 (I-69), is the Eastex Freeway. To the south, which is also co-signed with I-69, it is the Southwest Freeway. The stretch of the Southwest Freeway just west of The Loop was formerly one of the busiest freeways in North America, with a peak AADT of 371,000 in 1998.
U.S. Route 281 (US 281) is a United States Numbered Highway that runs from the Mexican border in the Rio Grande Valley to the Canadian border near Dunseith, North Dakota. In the state of Texas, the highway is a major south–north corridor, connecting Brownsville to the Oklahoma state line at the Red River in Burkburnett. Several segments of U.S. 281 are concurrent with Interstate routes, including I-69C in the Rio Grande Valley, I-37 in San Antonio, and I-44 north of Wichita Falls.
U.S. Route 77 (US 77) is a major highway that is part of the United States Numbered Highway System that runs from the Veterans International Bridge in Brownsville to Sioux City, Iowa. In Texas, the road runs south-north for 471.3 miles (758.5 km) from the International border with Mexico to the Oklahoma state line north of Gainesville. The highway is being upgraded to a freeway near Corpus Christi to connect to the freeway part of the highway in Raymondville as part of future I-69. A freeway in Robstown is already signed as part of I-69. From Waco to the Oklahoma state line, US 77 overlaps or runs parallel to I-35/I-35E.
Business Interstate 27-U is a business loop in the US state of Texas. It stretches 9.282 miles (14.938 km) along Columbia Street through Plainview between exits 45 and 53 on Interstate 27 (I-27). The highway follows the original alignment of U.S. Route 87 (US 87) prior to the construction of the new freeway to the west. Before becoming Bus. I-27-U, it was designated as Loop 445 and signed as a business route of US 87. Along the way, it intersects Farm to Market Road 3466, US 70 (5th Street), and FM 1767 (34th Street).
All of the business loops within Texas are maintained by the Texas Department of Transportation (TxDOT). Interstate 20 (I-20) has 15 business loops in the state, all located in western Texas. Along I-20, TxDOT identifies each business route as Business Interstate 20 followed by an alphabetic suffix. Along Texas Interstates, the alphabetic suffixes on business route names ascend eastward and northward. There are gaps in the alphabetic values to allow for future system expansion. The alphabetic naming suffixes are included as small letters on the bottom of route shields.
Interstate 69C (I-69C) is a north–south Interstate Highway running through South Texas. Once complete, the freeway will begin at I-2/U.S. Highway 83 (US 83) in Pharr and head northward before terminating at I-69W/US 59 in George West near I-37. For its entire length, I-69C is concurrent with US 281. As of 2023, only an 18-mile (29 km) segment has been completed at the route's southern terminus in Pharr.
Interstate 2 (I-2) is a partially completed Interstate Highway running through the Lower Rio Grande Valley of South Texas. It begins at the intersection of US Highway 83 (US 83) and Business US 83 in Peñitas and heads eastward before terminating at I-69E/US 77/US 83 in Harlingen. A westward extension around La Joya has been partially completed, but not yet part of I-2. For almost its entire length, I-2 runs concurrently with US 83. I-2 also parallels Mexican Federal Highway 2 (Fed. 2), another major east–west route that traces the Mexico–US border along the Mexican side of the Rio Grande. When completed, the western terminus will be the city of Laredo. The route is one of the more recently designated Interstate Highways; it was signed as an Interstate in 2013. Its construction is part of an expansion of the Interstate System into southern Texas that includes the three branches of I-69. It currently intersects I-69E and I-69C and will, when completed to Laredo, terminate I-69W as well. This complex of Interstate Highways does not yet connect to the rest of the system.
There are currently three business routes of U.S. Route 83 in Texas that are designated and maintained by the Texas Department of Transportation (TxDOT). The business routes in the US state of Texas are traditionally short spurs or loops that connect the main route, in this case, U.S. Route 83 (US 83), to the center or commercial district of a city. The routes commonly follow the course of a decommissioned state highway, or the old course of the main route. Business routes are signed with the traditional US 83 highway shield, and with a small "business plate" placed above the marker. TxDOT regards business routes as official highways, and is responsible for the maintenance of the route.
I-2 / US 83 in Peñitas 
