UV-328

Last updated
UV-328
UV-328.svg
Names
Preferred IUPAC name
2-(2H-1,2,3-Benzotriazol-2-yl)-4,6-bis(2-methylbutan-2-yl)phenol
Other names
2-(2H-Benzotriazol-2-yl)-4,6-di-tert-pentylphenol; Tinuvin-328; UV-328
Identifiers
3D model (JSmol)
ChemSpider
ECHA InfoCard 100.043.062 OOjs UI icon edit-ltr-progressive.svg
EC Number
  • 247-384-8
PubChem CID
UNII
  • InChI=1S/C22H29N3O/c1-7-21(3,4)15-13-16(22(5,6)8-2)20(26)19(14-15)25-23-17-11-9-10-12-18(17)24-25/h9-14,26H,7-8H2,1-6H3
    Key: ZMWRRFHBXARRRT-UHFFFAOYSA-N
  • CCC(C)(C)C1=CC(=C(C(=C1)N2N=C3C=CC=CC3=N2)O)C(C)(C)CC
Properties
C22H29N3O
Molar mass 351.494 g·mol−1
AppearanceSolid
Melting point 80-86 °C [1]
0,17±0,07 μg·l−1 (25 °C) [2]
Hazards
GHS labelling:
GHS-pictogram-exclam.svg
Warning
H373, H413
P260, P273, P314, P501
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).

UV-328 (2-(2H-benzotriazol-2-yl)-4,6-di-tert-pentylphenol) is a chemical compound that belongs to the phenolic benzotriazoles. It is a UV filter that is used as an UV-absorber for plastics. [3]

Contents

Properties

UV-328 has a melting point of 80-86 °C, a vapor pressure of 4,6·10−5 Pa (20 °C) and a water solubility of 0,17±0,07 μg·l−1 (25 °C). [2]

The octanol-water partition coefficient (log KOW) is 7,93. [2] [4]

Applications

UV-328 is a light stabilizer for a variety of plastics and other organic substrates. It has been used for the stabilization of styrene homopolymers and copolymers, acrylic polymers, unsaturated polyesters, polyvinyl chloride, polyolefins, polyurethanes, polyacetals, polyvinyl butyral, elastomers and adhesives. [5] It protects polymers and organic pigments from UV radiation and helps maintain the original appearance and physical integrity of moldings, films, sheets and fibers during outdoor weathering. The application concentration is 0.1-1 %. [5]

UV-328 has been used for applications such as automotive coatings, industrial coatings, commercial inks such as wood stains or do-it-yourself inks. [6]

Hazard

UV-328 is persistent, bioaccumulative and toxic (PBT) as well as very persistent and very bioaccumulative (vPvB). Thus, it is in the list of substances of very high concern. [7] The 2023 Conference of the Parties of the United Nations Stockholm Convention on Persistent Organic Pollutants took the decision to eliminate the use of UV-328, by listing this chemical in Annex A to the Convention. [8]

A bioaccumulation factor (log BAF) of 2,6–3,4 was determined in fish from Canadian rivers. [9] It may cause long lasting harmful effects to aquatic life. [10]

UV-328 has been found to be associated with adverse health effects in mammals based on repeated-dose toxicity studies conducted in rats and dogs, with the primary health effect being liver toxicity. It is also associated with adverse effects on the kidney based on the study in rats. [11]

The finding of UV-328 in plastics sampled on remote beaches, [12] in stomachs of seabirds [13] and in preen gland oil [14] [15] show that it is also transported over long distances and is taken up by biota. [16] Detections in Arctic biota include eggs of common eider, kittiwake, European shag and glaucous gull as well as the livers of mink. [17]

See also

References

  1. ↑ Wypych, Anna (2015-07-08). Databook of UV Stabilizers. Elsevier. ISBN   978-1-927885-03-1.
  2. 1 2 3 Ngoc Do, Anh T.; Ha, Yeonjeong; Kang, Hyun-Joong; Kim, Ju Min; Kwon, Jung-Hwan (April 2022). "Equilibrium leaching of selected ultraviolet stabilizers from plastic products". Journal of Hazardous Materials. 427: 128144. Bibcode:2022JHzM..42728144N. doi:10.1016/j.jhazmat.2021.128144. PMID   34979390.
  3. ↑ Zhang, Yue; Zhao, Hui; Feng, Qianxi; Guo, Rui; Zhong, Li; Liang, Shengxian (January 2025). "Effects of benzotriazoles UV-328, UV-329, and UV-P on the self-renewal and adipo-osteogenic differentiation of human mesenchymal stem cells". Ecotoxicology and Environmental Safety. 290: 117765. doi: 10.1016/j.ecoenv.2025.117765 . PMID   39847882.
  4. ↑ Do, Anh T. Ngoc; Ha, Yeonjeong; Kang, Hyun-Joong; Kim, Ju Min; Kwon, Jung-Hwan (May 2022). "Corrigendum to 'Equilibrium leaching of selected ultraviolet stabilizers from plastic products' [J. Hazard. Mater. 427 (2022) 128144]". Journal of Hazardous Materials. 430: 128487. Bibcode:2022JHzM..43028487D. doi:10.1016/j.jhazmat.2022.128487. PMID   35183055.
  5. 1 2 "Ciba® TINUVIN® 328 Benzotriazole UV Absorber" (PDF).
  6. ↑ "Ciba® TINUVIN® 328 Light Stabiliser" (PDF). Ciba Speciality Chemicals.
  7. ↑ "Candidate List of substances of very high concern for Authorisation - ECHA". echa.europa.eu. Retrieved 2019-05-28.
  8. ↑ "Governments accelerate action and take bold decisions to address pollution from chemicals and wastes". Secretariat of the Basel, Rotterdam and Stockholm Conventions. May 15, 2023. Retrieved 6 July 2023.
  9. ↑ Castilloux, Abigaëlle Dalpé; Houde, Magali; Gendron, Andrée; De Silva, Amila; Soubaneh, Youssouf Djibril; Lu, Zhe (19 April 2022). "Distribution and Fate of Ultraviolet Absorbents and Industrial Antioxidants in the St. Lawrence River, Quebec, Canada". Environmental Science & Technology. 56 (8): 5009–5019. Bibcode:2022EnST...56.5009C. doi:10.1021/acs.est.1c07932. PMC   9022226 . PMID   35395156.
  10. ↑ "Classifications - CL Inventory". echa.europa.eu. Retrieved 2020-12-24.
  11. ↑ "Opinion on the specific target organ toxicity of 2-benzotriazol-2-yl-4,6-di-tert-butylphenol (UV-320) and 2-(2H-benzotriazol-2-yl)-4,6-ditertpentylphenol (UV-328)". echa.europa.eu. Retrieved 2024-01-17.
  12. ↑ Tanaka, Kosuke; Takada, Hideshige; Ikenaka, Yoshinori; Nakayama, Shouta M.M.; Ishizuka, Mayumi (January 2020). "Occurrence and concentrations of chemical additives in plastic fragments on a beach on the island of Kauai, Hawaii". Marine Pollution Bulletin. 150: 110732. Bibcode:2020MarPB.15010732T. doi:10.1016/j.marpolbul.2019.110732. PMID   31757391.
  13. ↑ Tanaka, Kosuke; van Franeker, Jan A.; Deguchi, Tomohiro; Takada, Hideshige (August 2019). "Piece-by-piece analysis of additives and manufacturing byproducts in plastics ingested by seabirds: Implication for risk of exposure to seabirds". Marine Pollution Bulletin. 145: 36–41. Bibcode:2019MarPB.145...36T. doi:10.1016/j.marpolbul.2019.05.028. PMID   31590798.
  14. ↑ Tanaka, Kosuke; Watanuki, Yutaka; Takada, Hideshige; Ishizuka, Mayumi; Yamashita, Rei; Kazama, Mami; Hiki, Nagako; Kashiwada, Fumika; Mizukawa, Kaoruko; Mizukawa, Hazuki; Hyrenbach, David; Hester, Michelle; Ikenaka, Yoshinori; Nakayama, Shouta M.M. (February 2020). "In Vivo Accumulation of Plastic-Derived Chemicals into Seabird Tissues". Current Biology. 30 (4): 723–728.e3. Bibcode:2020CBio...30E.723T. doi: 10.1016/j.cub.2019.12.037 . PMID   32008901.
  15. ↑ Yamashita, Rei; Hiki, Nagako; Kashiwada, Fumika; Takada, Hideshige; Mizukawa, Kaoruko; Hardesty, Britta Denise; Roman, Lauren; Hyrenbach, David; Ryan, Peter G.; Dilley, Ben J.; MuñOz-PéRez, Juan Pablo; Valle, Carlos A.; Pham, Christopher K.; Frias, João; Nishizawa, Bungo; Takahashi, Akinori; Thiebot, Jean-Baptiste; Will, Alexis; Kokubun, Nobuo; Watanabe, Yuuki Y.; Yamamoto, Takashi; Shiomi, Kozue; Shimabukuro, Ui; Watanuki, Yutaka (2021). "Plastic additives and legacy persistent organic pollutants in the preen gland oil of seabirds sampled across the globe". Environmental Monitoring and Contaminants Research. 1: 97–112. doi: 10.5985/emcr.20210009 .
  16. ↑ Andrade, Helena; Glüge, Juliane; Herzke, Dorte; Ashta, Narain Maharaj; Nayagar, Shwetha Manohar; Scheringer, Martin (December 2021). "Oceanic long-range transport of organic additives present in plastic products: an overview". Environmental Sciences Europe. 33 (1). doi: 10.1186/s12302-021-00522-x . hdl: 11250/2767248 .
  17. ↑ Schlabach; et al. (2019). "Screening program 2018: Volatiles, Gd, BADGE, UV filters, Additives, and Medicines" (PDF). NILU, NIVA.
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