Undurti Narasimha Das | |
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Born | Kakinada, Andhra Pradesh, India | 28 June 1950
Nationality | Indian |
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Known for | Studies on Endocrinology and Rheumatology |
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Undurti Narasimha Das (born 1950) shortly Undurti N. Das and U. N. Das is an Indian clinical immunologist, endocrinologist and the founder president and chief executive officer of UND Life Sciences. [1] Additionally, he serves as the Chief Medical Officer and the Chairman of the Scientific Advisory Board of Asha Nutrition Sciences, Inc. [2] An elected fellow of the National Academy of Medical Sciences, [3] Das is known for his researches in the fields of Immunology, Endocrinology and Rheumatology. [4] He holds a number of patents for his work [5] The Council of Scientific and Industrial Research, the apex agency of the Government of India for scientific research, awarded him the Shanti Swarup Bhatnagar Prize for Science and Technology, one of the highest Indian science awards for his contributions to Medical Sciences in 1992. [6] [note 1]
Born to Kameshwari and Undurti Sitarama Swamy on 28 June 1950 at Kakinada, a large city in the south Indian state of Andhra Pradesh, Undurti N. Das graduated in medicine from Andhra Medical College of the Andhra University in 1973. [7] Subsequently, he joined Osmania Medical College as a senior research fellow of the Indian Council of Medical Research and the Council of Scientific and Industrial Research, simultaneously pursuing his higher studies to secure an MD in 1981. He continued at the institution at the Department of Genetics as an ICMR Research Associate, doing his post-doctoral work for 3 years. In 1984, he moved to Canada to join Efamol Research Institute, Kentville, as a scientist, where he stayed for two years, and on his return to India in 1986, he joined Nizam's Institute of Medical Sciences as an associate professor at the department of clinical pharmacology and medical research. [5] He served the institution till 1996, holding the position of a professor from 1990 onward. For the next three years, he was with L. V. Prasad Eye Institute as a professor and the head of the Division of Internal Medicine, Clinical Immunology and Biochemistry. In 1999, he had his second stint abroad, this time in the US, where he chaired EFA Sciences, Norwood as its research director. His service at EFA lasted till 2004, during which period he also served as a research professor of surgery, nutrition, and physiology at the State University of New York Upstate Medical University from 2003 to 2004. That year, he founded UND Life Sciences at Shaker Heights, Ohio, a biotechnology company, [8] and became its founder president and chief executive officer. [9] Between 2007 and 2009, he had a brief stay in India as the Research Director of IKP Centre for Technologies in Public Health, Chennai. [7]
Das is married to Lakshmi and the couple has two children, Arundhati and Aditya. He holds the positions of the CEO and research director of UND Life Sciences [10] and is a director of Primrose Biosciences, [11] a Hyderabad-based company involved in research and experimental development in the field of natural sciences and engineering. [12]
On January 1, 2013, Dr. Das joined Asha Nutrition Sciences, Inc. as the Chief Medical Officer and the Chairman of the Scientific Advisory Board. [13]
Researches of U. N. Das are focused on various disease processes and his researches have revealed the tumoricidal properties of cis-unsaturated fatty acids as well as the role of gamma-Linolenic acid in controlling the progress of glioma, a type of tumor which affects brain and spinal cord. [14] He has also worked on drug development to combat diseases and conditions such as obesity, cancer, diabetes, hypertension and schizophrenia. [15] [16] His researches have been documented by way of several articles; [17] [note 2] ResearchGate an online repository of scientific articles has listed 500 of them. [17] Besides, he has authored three books, viz. Metabolic Syndrome Pathophysiology: The Role of Essential Fatty Acids, [18] Molecular Basis of Health and Disease [19] [note 3] and A Perinatal Strategy For Preventing Adult Disease: The Role of Long-Chain Polyunsaturated Fatty Acids. [20] He holds a number of patents for his work, which include "Method of potentiating the action of 2-methoxyoestradiol, statins and C-peptide of proinsulin, [21] Method(s) of stabilizing and potentiating the actions and administration of brain-derived neurotrophic factor (BDNF) [22] Method of stabilizing and potentiating the action of anti-angiogenic substances, [23] Method(s) of preventing, arresting, reversing and treatment of atherosclerosis, [24] and Methods for selectively occluding blood supplies to neoplasias [25] and Butyrylcholinesterase as a marker of low-grade systemic inflammation. [26]
Das is the editor-in-chief of Lipids in Health and Disease, a journal published by BioMed Central [27] and Current Nutrition & Food Science, published by Bentham Science. [28] [note 4] He is the section editor of Medicine journal, [29] a member of the editorial board of the controversial and non-peer reviewed journal Medical Hypotheses [30] and the Journal of Geriatric Cardiology [31] and sits in the scientific advisory board of Techno Scienze Publisher [32] which publishes a number of journals. [33] He is also a member of the editorial review board of Journal of Applied Research in Clinical and Experimental Therapeutics [34] and has been associated with a number of other journals as a member of their editorial boards or the Panel of Reviewers which include World Journal of Diabetes, [35] European Journal of General Medicine, Journal of the Association of Physicians of India, Frontiers in Biosciences, Diabetes Review Letters, Open Colorectal Cancer Journal, Indian Journal of Medical Research [36] and Gene Therapy and Molecular Biology. [7] He has also been a member of the International Advisory Board of the II International Conference on Functional Foods for the Prevention and Treatment of Chronic Diseases, organized by Functional Foods Center, held in November, 2005 at Richardson, Texas; [37]
Das, a Ramalingaswamy Re-entry Fellow of the Department of Biotechnology, [10] received the Shakuntala Amirchand Prize of the Indian Council of Medical Research in 1988 [7] and the Council of Scientific and Industrial Research awarded him Shanti Swarup Bhatnagar Prize, one of the highest Indian science awards in 1992. [38] He delivered the Dr. Coelho Memorial Award Oration of Association of Physicians of India in 1992; [9] the same year as he received the Regional Research Award of the Japanese Society of Clinical Chemistry.[ citation needed ] He also received two minor awards in 1992 viz. Yagnavalki Sangham Award and Distinguished Citizen Award of Pramukh Swamy Maharaj of Aksharadham and the Karnataka Association of Physicians of India awarded him the Bobba Dharma Rao Prize in 1994. [7] In between, the National Academy of Medical Sciences elected him as a fellow in 1992 [39] and the Indian College of Physicians followed suit in 1993. [7] He is also a fellow of the Royal Society of Chemistry, a founder member of Telangana Academy of Sciences [40] and a member of science organizations such as New York Academy of Sciences, American Association for the Advancement of Science and Society for Experimental Biology and Medicine, New York.[ citation needed ]
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: CS1 maint: multiple names: authors list (link)In nutrition, biology, and chemistry, fat usually means any ester of fatty acids, or a mixture of such compounds, most commonly those that occur in living beings or in food.
Omega−3 fatty acids, also called Omega−3 oils, ω−3 fatty acids or n−3 fatty acids, are polyunsaturated fatty acids (PUFAs) characterized by the presence of a double bond, three atoms away from the terminal methyl group in their chemical structure. They are widely distributed in nature, being important constituents of animal lipid metabolism, and they play an important role in the human diet and in human physiology. The three types of omega−3 fatty acids involved in human physiology are α-linolenic acid (ALA), eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA). ALA can be found in plants, while DHA and EPA are found in algae and fish. Marine algae and phytoplankton are primary sources of omega−3 fatty acids. DHA and EPA accumulate in fish that eat these algae. Common sources of plant oils containing ALA include walnuts, edible seeds, and flaxseeds as well as hempseed oil, while sources of EPA and DHA include fish and fish oils, and algae oil.
A dietary supplement is a manufactured product intended to supplement a person's diet by taking a pill, capsule, tablet, powder, or liquid. A supplement can provide nutrients either extracted from food sources, or that are synthetic. The classes of nutrient compounds in supplements include vitamins, minerals, fiber, fatty acids, and amino acids. Dietary supplements can also contain substances that have not been confirmed as being essential to life, and so are not nutrients per se, but are marketed as having a beneficial biological effect, such as plant pigments or polyphenols. Animals can also be a source of supplement ingredients, such as collagen from chickens or fish for example. These are also sold individually and in combination, and may be combined with nutrient ingredients. The European Commission has also established harmonized rules to help insure that food supplements are safe and appropriately labeled.
Essential fatty acids, or EFAs, are fatty acids that humans and other animals must ingest because the body requires them for good health, but cannot synthesize them.
α-Linolenic acid, also known as alpha-Linolenic acid (ALA), is an n−3, or omega-3, essential fatty acid. ALA is found in many seeds and oils, including flaxseed, walnuts, chia, hemp, and many common vegetable oils.
A saturated fat is a type of fat in which the fatty acid chains have all single bonds. A fat known as a glyceride is made of two kinds of smaller molecules: a short glycerol backbone and fatty acids that each contain a long linear or branched chain of carbon (C) atoms. Along the chain, some carbon atoms are linked by single bonds (-C-C-) and others are linked by double bonds (-C=C-). A double bond along the carbon chain can react with a pair of hydrogen atoms to change into a single -C-C- bond, with each H atom now bonded to one of the two C atoms. Glyceride fats without any carbon chain double bonds are called saturated because they are "saturated with" hydrogen atoms, having no double bonds available to react with more hydrogen.
Arachidonic acid is a polyunsaturated omega-6 fatty acid 20:4(ω-6), or 20:4(5,8,11,14). It is structurally related to the saturated arachidic acid found in cupuaçu butter. Its name derives from the Neo-Latin word arachis (peanut), but peanut oil does not contain any arachidonic acid.
Omega-6 fatty acids are a family of polyunsaturated fatty acids that have in common a final carbon-carbon double bond in the n-6 position, that is, the sixth bond, counting from the methyl end.
Linoleic acid (LA) is an organic compound with the formula HOOC(CH
2)
7CH=CHCH
2CH=CH(CH
2)
4CH
3. Both alkene groups are cis. It is a fatty acid sometimes denoted 18:2 (n-6) or 18:2 cis-9,12. A linoleate is a salt or ester of this acid.
In biochemistry and nutrition, a monounsaturated fat is a fat that contains a monounsaturated fatty acid (MUFA), a subclass of fatty acid characterized by having a double bond in the fatty acid chain with all of the remaining carbon atoms being single-bonded. By contrast, polyunsaturated fatty acids (PUFAs) have more than one double bond.
Docosahexaenoic acid (DHA) is an omega-3 fatty acid that is a primary structural component of the human brain, cerebral cortex, skin, and retina. In physiological literature, it is given the name 22:6(n-3). It can be synthesized from alpha-linolenic acid or obtained directly from maternal milk, fatty fish, fish oil, or algae oil.
David Mark Hegsted was an American nutritionist who studied the connections between food consumption and heart disease. His work included studies that showed that consumption of saturated fats led to increases in cholesterol, leading to the development of dietary guidelines intended to help Americans achieve better health through improved food choices.
Egg oil, also known as egg yolk oil or ovum oil, is derived from the yolk of chicken eggs consisting mainly of triglycerides with traces of lecithin, cholesterol, biotin, xanthophylls lutein and zeaxanthin, and immunoglobulins. It is free of egg proteins and hence may be used safely by people who are allergic to eggs, for topical applications such as hair and skin care. The product has several historical references in Unani (Greek) medicine for hair care. Traditional Chinese medicine uses egg oil for burns, eczema, dermatitis, mouth ulcers, skin ulcers, chapped nipples, tinea capitis, ringworm, nasal vestibulitis, frostbite, and hemorrhoids.
George Edward Billman is an American physiologist and professor at Ohio State University. After receiving a Ph.D from the University of Kentucky in 1980, Billman began his professional career at the University of Oklahoma. In 1984, he joined the Ohio State staff, where he became an associate professor in 1990 and a full professor in 1996.
Cooking oil is a plant or animal liquid fat used in frying, baking, and other types of cooking. Oil allows higher cooking temperatures than water, making cooking faster and more flavorful, while likewise distributing heat, reducing burning and uneven cooking. It sometimes imparts its own flavor. Cooking oil is also used in food preparation and flavoring not involving heat, such as salad dressings and bread dips.
Asim K. Duttaroy is an Indian-born American medical scientist who, since 2001, has worked as a Professor at the Faculty of Medicine, University of Oslo, Norway. He was born in Gopinagar (Gangnapur), Nadia district, West Bengal, India.
Rajesh Sudhir Gokhale is currently the Secretary for Department of Biotechnology (DBT) and Department of Science & Technology (DST), Government of India. He joined National Institute of immunology after conducting his postdoctoral training at Stanford University, He was the director of Institute of Genomics and Integrative Biology from 2009 to 2016. Gokhale is known for his studies on the metabolic diversity of pathogens. He is credited with the discovery of a family of Long-chain Fatty acyl-AMP ligases (FAAL) and his studies assisted in the elucidation of biochemical crosstalk between fatty acid synthases and polyketide synthases in Mycobacterium tuberculosis. He holds US and Indian patents for his invention of Method to Modulate Pigmentation Process in the Melanocytes of Skin. An alumnus of the Indian Institute of Science, he is an elected fellow of the Indian Academy of Sciences (2007) and the Indian National Science Academy (2014). The Council of Scientific and Industrial Research, the apex agency of the Government of India for scientific research, awarded him the Shanti Swarup Bhatnagar Prize for Science and Technology, one of the highest Indian science awards, in 2006, for his contributions to biological sciences. He received the National Bioscience Award for Career Development of the Department of Biotechnology in 2009.
Chinmoy Sankar Dey is an Indian molecular biologist and a professor at Kusuma School of Biological Sciences of the Indian Institute of Technology, Delhi. Known for his research on insulin resistance, Dey's is a J. C. Bose National Fellow of the Department of Science and Technology and an elected fellow of the National Academy of Sciences, India and the Indian National Science Academy. The Council of Scientific and Industrial Research, the apex agency of the Government of India for scientific research, awarded him the Shanti Swarup Bhatnagar Prize for Science and Technology, one of the highest Indian science awards for his contributions to Medical Sciences in 2003. He is also a recipient of the National Bioscience Award for Career Development of the Department of Biotechnology.
Ravinder Goswami is an Indian endocrinologist and professor at the department of endocrinology and metabolism at the All India Institute of Medical Sciences, Delhi. Known for his research on vitamin D deficiency, Goswami is an elected fellow of National Academy of Sciences, India and Indian Academy of Sciences. The Council of Scientific and Industrial Research, the apex agency of the Government of India for scientific research, awarded him the Shanti Swarup Bhatnagar Prize for Science and Technology, one of the highest Indian science awards for his contributions to Medical Sciences in 2008.
Trans fat, also called trans-unsaturated fatty acids, or trans fatty acids, is a type of unsaturated fat that occurs in foods. Trace concentrations of trans fats occur naturally, but large amounts are found in some processed foods. Since consumption of trans fats is unhealthy, artificial trans fats are highly regulated or banned in many nations. However, they are still widely consumed in developing nations, resulting in hundreds of thousands of deaths each year. The World Health Organization (WHO) has set a goal to make the world free from industrially produced trans fat by the end of 2023.
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