| Urodacus manicatus | |
|---|---|
 | |
Scientific classification  | |
| Domain: | Eukaryota |
| Kingdom: | Animalia |
| Phylum: | Arthropoda |
| Subphylum: | Chelicerata |
| Class: | Arachnida |
| Order: | Scorpiones |
| Family: | Urodacidae |
| Genus: | Urodacus |
| Species: | U. manicatus |
| Binomial name | |
| Urodacus manicatus | |
| Synonyms | |
| |
Urodacus manicatus, commonly known as the black rock scorpion, is a species of scorpion belonging to the family Urodacidae. It is native to eastern Australia.
The black rock scorpion was described by Swedish naturalist Tamerlan Thorell in 1876 as Ioctonus manicatus. [1] The type locality was described as "New Holland". [2] In 1888 Reginald Innes Pocock, an assistant at the Natural History Museum in London, was cataloging specimens of the genus and described what he thought was a new species—naming it U. abruptus— from two dried female specimens, one from Adelaide and the other labelled "New Holland". [3] German naturalist Karl Kraepelin concluded that Thorell's I. manicatus was the same species as U. abruptus and U. novaehollandiae. [4] It was also collected from Cooma by William Joseph Rainbow who named it Buthus flavicruris in 1896. [2] The genus Urodacus was placed in its own family in 2000. Before this, the group had been a subfamily Urodacinae within the family Scorpionidae. [5]
Measuring up to 5.5 cm (2.2 in), it is dark brown or black.
The species ranges from Queensland through New South Wales and Victoria into South Australia. [6] Its preferred habitat is granite outcrops in open forest. [7]
The scorpion excavates a burrow underneath rocks or logs with a terminal chamber and passage to the surface. It preys upon insects such as cockroaches and beetles, as well as other invertebrates such as millipedes, centipedes, spiders and rarely earthworms. Its sting can cause local pain and swelling in humans. [6]
It is one of the species of scorpion most commonly seen for sale in pet shops in Australia and is relatively easy to keep in captivity, where it has a lifespan of 6 to 10 years. There are concerns wild populations are being depleted because of specimens taken for the pet trade. [7]
U. manicatus was recently shown to harbor a unique peptide toxin, presumably for defensive purposes. This cell-penetrating peptide selectively activates mammalian TRPA1 receptors, which are expressed in pain-sensing peripheral neurons, to produce acute pain and pain hypersensitivities, but not inflammation. For mechanistic insights into this discrepancy, see ref. [8] [9] Because TRPA1 is also known as the 'Wasabi Receptor,' given its role as the principle detector of the piquant ingredients in Brassica and Allium (mustard and onion) family plants, this U. manicatus toxin has been named the Wasabi Receptor Toxin or WaTx [10]
Wasabi or Japanese horseradish is a plant of the family Brassicaceae, which also includes horseradish and mustard in other genera. The plant is native to Japan, the Russian Far East including Sakhalin, and the Korean Peninsula. It grows naturally along stream beds in mountain river valleys in Japan.
Uropygi is an arachnid order comprising invertebrates commonly known as whip scorpions or vinegaroons. They are often called uropygids. The name "whip scorpion" refers to their resemblance to true scorpions and possession of a whiplike tail, and "vinegaroon" refers to their ability when attacked to discharge an offensive, vinegar-smelling liquid, which contains acetic acid. The order may also be called Thelyphonida. Both names, Uropygi and Thelyphonida, may be used either in a narrow sense for the order of whip scorpions, or in a broad sense which includes the order Schizomida.
In chemistry, an electrophile is a chemical species that forms bonds with nucleophiles by accepting an electron pair. Because electrophiles accept electrons, they are Lewis acids. Most electrophiles are positively charged, have an atom that carries a partial positive charge, or have an atom that does not have an octet of electrons.
Sensory neurons, also known as afferent neurons, are neurons in the nervous system, that convert a specific type of stimulus, via their receptors, into action potentials or graded receptor potentials. This process is called sensory transduction. The cell bodies of the sensory neurons are located in the dorsal root ganglia of the spinal cord.
Transient receptor potential channels are a group of ion channels located mostly on the plasma membrane of numerous animal cell types. Most of these are grouped into two broad groups: Group 1 includes TRPC, TRPV, TRPVL, TRPM, TRPS, TRPN, and TRPA. Group 2 consists of TRPP and TRPML. Other less-well categorized TRP channels exist, including yeast channels and a number of Group 1 and Group 2 channels present in non-animals. Many of these channels mediate a variety of sensations such as pain, temperature, different kinds of taste, pressure, and vision. In the body, some TRP channels are thought to behave like microscopic thermometers and used in animals to sense hot or cold. Some TRP channels are activated by molecules found in spices like garlic (allicin), chili pepper (capsaicin), wasabi ; others are activated by menthol, camphor, peppermint, and cooling agents; yet others are activated by molecules found in cannabis or stevia. Some act as sensors of osmotic pressure, volume, stretch, and vibration. Most of the channels are activated or inhibited by signaling lipids and contribute to a family of lipid-gated ion channels.
Neurogenic inflammation is inflammation arising from the local release by afferent neurons of inflammatory mediators such as Substance P, Calcitonin Gene-Related Peptide (CGRP), neurokinin A (NKA), and endothelin-3 (ET-3). In such neurons, release of these pro-inflammatory mediators is thought to be triggered by the activation of ion channels that are the principal detectors of noxious environmental stimuli. In particular, the heat/capsaicin receptor TRPV1 and the irritant/wasabi receptor TRPA1. TRPA1 channels stimulated by lipopolysaccharide (LPS) may also cause acute neurogenic inflammation. Once released, these neuropeptides induce the release of histamine from adjacent mast cells. In turn, histamine evokes the release of substance P and calcitonin gene-related peptide; thus, a bidirectional link between histamine and neuropeptides in neurogenic inflammation is established.
The Buthidae are the largest family of scorpions, containing about 100 genera and 1339 species as of 2022. A few very large genera are known, but a high number of species-poor or monotypic ones also exist. New taxa are being described at a rate of several new species per year. They have a cosmopolitan distribution throughout tropical and subtropical environments worldwide. Together with four other families, the Buthidae make up the superfamily Buthoidea. The family was established by Carl Ludwig Koch in 1837.
Transient receptor potential cation channel, subfamily A, member 1, also known as transient receptor potential ankyrin 1, TRPA1, or The Wasabi Receptor, is a protein that in humans is encoded by the TRPA1 gene.
Scorpion toxins are proteins found in the venom of scorpions. Their toxic effect may be mammal- or insect-specific and acts by binding with varying degrees of specificity to members of the Voltage-gated ion channel superfamily; specifically, voltage-gated sodium channels, voltage-gated potassium channels, and Transient Receptor Potential (TRP) channels. The result of this action is to activate or inhibit the action of these channels in the nervous and cardiac organ systems. For instance, α-scorpion toxins MeuNaTxα-12 and MeuNaTxα-13 from Mesobuthus eupeus are neurotoxins that target voltage-gated Na+ channels (Navs), inhibiting fast inactivation. In vivo assays of MeuNaTxα-12 and MeuNaTxα-13 effects on mammalian and insect Navs show differential potency. These recombinants exhibit their preferential affinity for mammalian and insect Na+ channels at the α-like toxins' active site, site 3, in order to inactivate the cell membrane depolarization faster[6]. The varying sensitivity of different Navs to MeuNaTxα-12 and MeuNaTxα-13 may be dependent on the substitution of a conserved Valine residue for a Phenylalanine residue at position 1630 of the LD4:S3-S4 subunit or due to various changes in residues in the LD4:S5-S6 subunit of the Navs. Ultimately, these actions can serve the purpose of warding off predators by causing pain or to subdue predators.
Heterometrus, whose members are also known by the collective vernacular name Asian Forest Scorpion, is a genus of scorpions belonging to the family Scorpionidae. It is distributed widely across tropical and subtropical southeastern Asia, including Indonesia, Brunei, Malaysia, Myanmar, Philippines, Singapore, Cambodia, Laos, Thailand, Vietnam, India, and China (Hainan). It is notable for containing some of the largest living species of scorpions.
Pandinus is a genus of large scorpions belonging to the family Scorpionidae. It contains one of the most popular pet scorpions, the emperor scorpion . The genus is distributed across tropical Africa.
Olivierus martensii is a species of scorpion in the family Buthidae. Its common names include Chinese scorpion, Manchurian scorpion, Chinese armor-tail scorpion and Chinese golden scorpion. Despite its common name, this scorpion is not only found in Manchuria or China, but also in Mongolia and Korea. The record from Japan is doubtful. Its preferred habitat is warm, dry areas with little vegetation. O. martensii can grow to about 6 centimetres (2.4 in) long, with females usually slightly larger, and has a life-span of about 4 to 6 years.
David Jay Julius is an American physiologist and Nobel Prize laureate known for his work on molecular mechanisms of pain sensation and heat, including the characterization of the TRPV1 and TRPM8 receptors that detect capsaicin, menthol, and temperature. He is a professor at the University of California, San Francisco.
Mesobuthus eupeus is a polymorphic scorpion species belonging to the well-known family Buthidae. Commonly known as the lesser Asian scorpion or the mottled scorpion. It is thought to be the most widely dispersed species of the genus Mesobuthus, perhaps even of the family Buthidae.
Cyrtarachne is a genus of orb-weaver spiders first described by Tamerlan Thorell in 1868.
Urodacus is a genus of scorpion belonging to the family Urodacidae. It was described by German naturalist Wilhelm Peters in 1861. The type species is U. novaehollandiae. Its species are native to Australia, and dig burrows. The genus was placed in its own family in 2000. Before this, the group had been a subfamily Urodacinae within the family Scorpionidae.
Wasabi receptor toxin (WaTx) is the active component of the venom of the Australian black rock scorpion Urodacus manicatus. WaTx targets TRPA1, also known as the wasabi receptor or irritant receptor. WaTx is a cell-penetrating toxin that stabilizes the TRPA1 channel open state while reducing its Ca2+-permeability, thereby eliciting pain and pain hypersensitivity without the neurogenic inflammation that typically occurs in other animal toxins.
Protoxin-I, also known as ProTx-I, or Beta/omega-theraphotoxin-Tp1a, is a 35-amino-acid peptide neurotoxin extracted from the venom of the tarantula Thrixopelma pruriens. Protoxin-I belongs to the inhibitory cystine knot (ICK) family of peptide toxins, which have been known to potently inhibit voltage-gated ion channels. Protoxin-I selectively blocks low voltage threshold T-type calcium channels, voltage gated sodium channels and the nociceptor cation channel TRPA1. Due to its unique ability to bind to TRPA1, Protoxin-I has been implicated as a valuable pharmacological reagent with potential applications in clinical contexts with regards to pain and inflammation
Urodacus armatus, also known as the yellow sand scorpion or inland desert scorpion, is a species of scorpion in the Urodacidae family. It is native to Australia. It was first described in 1888 by British zoologist Reginald Innes Pocock.
Urodacus excellens is a species of scorpion in the Urodacidae family. It is endemic to Australia, and was first described in 1888 by British zoologist Reginald Innes Pocock.
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