Urogenital sinus

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Urogenital sinus
Gray1109.png
Urogenital sinus of female human embryo of eight and a half to nine weeks old. (Urogenital sinus labeled at bottom.)
Development of external sexual organs in the male and female Gray1119.png
Stages in the development of the external sexual organs in the male and female. ("Opening of urogenital sinus" labeled in diagram D.)
Details
Carnegie stage 15
Precursor Cloaca
Gives rise to urethra, bladder, vagina
Identifiers
Latin sinus urogenitalis definitivus
TE sinus_by_E5.7.3.1.0.0.1 E5.7.3.1.0.0.1
Anatomical terminology

The urogenital sinus is a part of the human body only present in the development of the urinary and reproductive organs. It is the ventral part of the cloaca, formed after the cloaca separates from the anal canal during the fourth to seventh weeks of development. [1]

Contents

In males, the UG sinus is divided into three regions: upper, pelvic, and phallic. The upper part gives rise to the urinary bladder and the pelvic part gives rise to the prostatic and membranous parts of the urethra, [1] the prostate and the bulbourethral gland (Cowper's). The phallic portion gives rise to the spongy (bulbar) part of the urethra and the urethral glands (Littré's). The penile part of the urethra originates from urogenital fold.

In females, the pelvic part of the UG sinus gives rise to the sinovaginal bulbs, structures that will eventually form the inferior two thirds of the vagina. This process begins when the lower tip of the paramesonephric ducts, the structures that will eventually form the uterus and vaginal fornices, come in contact with the UG sinus. Shortly afterwards, the sinovaginal bulbs form as two solid evaginations of the UG sinus. Cells in these bulbs divide to form a solid vaginal plate, which extends and then canalizes (hollows) to form the inferior portion of the vagina. [2] The female urogenital sinus also gives rise to the urethra and vestibule of the vagina.

Clinical significance

A urogenital sinus anomaly is also a rare birth defect in women where the urethra and vagina both open into a common channel. [3] [4]

A persistent cloaca is a disorder where the rectum, vagina, and urinary tract meet and fuse, creating a cloaca, a single common channel. [5]

Other animals

In most mammals (excluding primates and species that have a cloaca), the urogenital sinus refers to the sinus in which the openings to the female's urethra and vagina are found. The urogenital sinus of non-primates is homologous to the vulval vestibule of primates.

Additional images

See also

Related Research Articles

<span class="mw-page-title-main">Urethra</span> Tube that connects the urinary bladder to the external urethral orifice

The urethra is a tube that connects the mammalian urinary bladder to the urinary meatus. Male and female placental mammals release urine through the urethra during urination, but males also release semen through the urethra during ejaculation.

<span class="mw-page-title-main">Bladder</span> Organ in vertebrates that collects and stores urine from the kidneys before disposal

The bladder is a hollow organ in humans and other vertebrates that stores urine from the kidneys before disposal by urination. In placental mammals, urine enters the bladder via the ureters and exits via the urethra. In humans, the bladder is a distensible organ that sits on the pelvic floor. The typical adult human bladder will hold between 300 and 500 ml before the urge to empty occurs, but can hold considerably more.

<span class="mw-page-title-main">Vagina</span> Part of the female reproductive tract

In mammals and other animals, the vagina is the elastic, muscular reproductive organ of the female genital tract. In humans, it extends from the vestibule to the cervix. The outer vaginal opening is normally partly covered by a thin layer of mucosal tissue called the hymen. At the deep end, the cervix bulges into the vagina. The vagina allows for copulation and birth. It also channels menstrual flow, which occurs in humans and closely related primates as part of the menstrual cycle.

<span class="mw-page-title-main">Prostate</span> Gland of the male reproductive system in most mammals

The prostate is both an accessory gland of the male reproductive system and a muscle-driven mechanical switch between urination and ejaculation. It is found in all male mammals. It differs between species anatomically, chemically, and physiologically. Anatomically, the prostate is found below the bladder, with the urethra passing through it. It is described in gross anatomy as consisting of lobes and in microanatomy by zone. It is surrounded by an elastic, fibromuscular capsule and contains glandular tissue, as well as connective tissue.

<span class="mw-page-title-main">Seminal vesicles</span> Pair of simple tubular glands posteroinferior to the urinary bladder of male mammals

The seminal vesicles are a pair of convoluted tubular accessory glands that lie behind the urinary bladder of male mammals. They secrete fluid that partly composes the semen.

<span class="mw-page-title-main">Mesonephric duct</span> Paired organ in mammals

The mesonephric duct, also known as the Wolffian duct, archinephric duct, Leydig's duct or nephric duct, is a paired organ that develops in the early stages of embryonic development in humans and other mammals. It is an important structure that plays a critical role in the formation of male reproductive organs. The duct is named after Caspar Friedrich Wolff, a German physiologist and embryologist who first described it in 1759.

<span class="mw-page-title-main">Cloaca</span> Posterior opening in zoology

A cloaca, pl.: cloacae, is the rear orifice that serves as the only opening for the digestive, reproductive, and urinary tracts of many vertebrate animals. All amphibians, reptiles, birds, and a few mammals, have this orifice, from which they excrete both urine and feces; this is in contrast to most placental mammals, which have two or three separate orifices for evacuation and reproduction. Excretory openings with analogous purpose in some invertebrates are also sometimes called cloacae. Mating through the cloaca is called cloacal copulation and cloacal kissing.

<span class="mw-page-title-main">Pelvic floor</span> Anatomical structure

The pelvic floor or pelvic diaphragm is an anatomical location in the human body, which has an important role in urinary and anal continence, sexual function and support of the pelvic organs. The pelvic floor includes muscles, both skeletal and smooth, ligaments and fascia. and separates between the pelvic cavity from above, and the perineum from below. It is formed by the levator ani muscle and coccygeus muscle, and associated connective tissue.

<span class="mw-page-title-main">Paramesonephric duct</span> Paired ducts in the embryo in the primitive urogenital structures

The paramesonephric ducts are paired ducts of the embryo in the female reproductive system that run down the lateral sides of the genital ridge and terminate at the sinus tubercle in the primitive urogenital sinus. In the female, they will develop to form the fallopian tubes, uterus, cervix, and the upper one-third of the vagina.

The development of the urinary system begins during prenatal development, and relates to the development of the urogenital system – both the organs of the urinary system and the sex organs of the reproductive system. The development continues as a part of sexual differentiation.

<span class="mw-page-title-main">Male reproductive system</span> Reproductive system of the human male

The male reproductive system consists of a number of sex organs that play a role in the process of human reproduction. These organs are located on the outside of the body, and within the pelvis.

Vaginal atresia is a condition in which the vagina is abnormally closed or absent. The main causes can either be complete vaginal hypoplasia, or a vaginal obstruction, often caused by an imperforate hymen or, less commonly, a transverse vaginal septum. It results in uterovaginal outflow tract obstruction. This condition does not usually occur by itself within an individual, but coupled with other developmental disorders within the female. The disorders that are usually coupled with a female who has vaginal atresia are Mayer-Rokitansky-Küster-Hauser syndrome, Bardet-Biedl syndrome, or Fraser syndrome. One out of every 5,000 women have this abnormality.

<span class="mw-page-title-main">Vulval vestibule</span> Part of the vulva that contains the openings

The vulval vestibule is the part of the vulva between the labia minora. On the inside, the urinary meatus and the vaginal opening open to the vestibule, while the outer edge is marked by Hart's line, named after David Berry Hart.

<span class="mw-page-title-main">Urachus</span> Structure of the urinary system

The urachus is a fibrous remnant of the allantois, a canal that drains the urinary bladder of the fetus that joins and runs within the umbilical cord. The fibrous remnant lies in the space of Retzius, between the transverse fascia anteriorly and the peritoneum posteriorly.

<span class="mw-page-title-main">Deep perineal pouch</span> Anatomic space enclosed partly by the perineum

The deep perineal pouch is the anatomic space enclosed in part by the perineum and located superior to the perineal membrane.

<span class="mw-page-title-main">Membranous urethra</span> Narrowest part of the urethra

The membranous urethra or intermediate part of male urethra is the shortest, least dilatable, and, with the exception of the urinary meatus, the narrowest part of the urethra.

<span class="mw-page-title-main">Cloaca (embryology)</span> Structure in the embryo

The cloaca is a structure in the development of the urinary and reproductive organs.

The development of the reproductive system is the part of embryonic growth that results in the sex organs and contributes to sexual differentiation. Due to its large overlap with development of the urinary system, the two systems are typically described together as the genitourinary system.

The sinovaginal bulb is a transitional structure in the development of female genitalia, and is one of a pair of endodermal outgrowths of the urogenital sinus, which later fuse to form the lower part of the vagina. The lower third of the vagina is derived from the urogenital sinus.

<span class="mw-page-title-main">Vaginal support structures</span> Structures that maintain the position of the vagina within the pelvic cavity

The vaginal support structures are those muscles, bones, ligaments, tendons, membranes and fascia, of the pelvic floor that maintain the position of the vagina within the pelvic cavity and allow the normal functioning of the vagina and other reproductive structures in the female. Defects or injuries to these support structures in the pelvic floor leads to pelvic organ prolapse. Anatomical and congenital variations of vaginal support structures can predispose a woman to further dysfunction and prolapse later in life. The urethra is part of the anterior wall of the vagina and damage to the support structures there can lead to incontinence and urinary retention.

References

  1. 1 2 Sadler & Langman 2010, pp. 243–244.
  2. Sadler & Langman 2010, pp. 253.
  3. Callahan, Gerald N. (2009). Between XX and XY : intersexuality and the myth of two sexes. Chicago, Ill.: Chicago Review Press. p. 182. ISBN   978-1-56976-289-9. OCLC   436089205.
  4. "Urogenital Sinus". Children's Hospital of Orange County. 2023-02-23. Retrieved 2023-10-07.
  5. Jenkins D, Bitner-Glindzicz M, Thomasson L, et al. (2007), "Mutational analyses of UPIIIA, SHH, EFNB2 and HNF1β in persistent cloaca and associated kidney malformations", J Pediatr Urol, 3 (1): 2–9, doi:10.1016/j.jpurol.2006.03.002, PMC   1864944 , PMID   17476318.

Sources