 | This sedative-related article is a stub. You can help Wikipedia by expanding it. |
 | |
 | |
| Clinical data | |
|---|---|
| Other names | Dolcental |
| Identifiers | |
| |
| CAS Number | |
| ChemSpider | |
| UNII | |
| CompTox Dashboard (EPA) | |
| Chemical and physical data | |
| Formula | C10H14N2O3 |
| Molar mass | 210.233 g·mol−1 |
| 3D model (JSmol) | |
| |
| |
Clocental (dolcental) is a carbamate-derived sedative hypnotic. It can be prepared by the ethynylation of cyclohexanone followed by reaction with allophanyl chloride. [1]
Von Hippel–Lindau disease (VHL), also known as VonHippel–Lindau syndrome, is a rare genetic disorder with multisystem involvement. It is characterized by visceral cysts and benign tumors with potential for subsequent malignant transformation. It is a type of phakomatosis that results from a mutation in the Von Hippel–Lindau tumor suppressor gene on chromosome 3p25.3.
In set theory, an uncountable cardinal is inaccessible if it cannot be obtained from smaller cardinals by the usual operations of cardinal arithmetic. More precisely, a cardinal κ is strongly inaccessible if it is uncountable, it is not a sum of fewer than κ cardinals smaller than κ, and implies .
In set theory and related branches of mathematics, the von Neumann universe, or von Neumann hierarchy of sets, denoted by V, is the class of hereditary well-founded sets. This collection, which is formalized by Zermelo–Fraenkel set theory (ZFC), is often used to provide an interpretation or motivation of the axioms of ZFC. The concept is named after John von Neumann, although it was first published by Ernst Zermelo in 1930.
Exo-α-sialidase is a glycoside hydrolase that cleaves the glycosidic linkages of neuraminic acids:
In organic chemistry, the Michael reaction or Michael addition describes a reaction between any Michael donor and any Michael acceptor. It belongs to the larger class of conjugate additions and is widely used for the mild formation of C–C bonds. Many asymmetric variants exist and depending on the conditions, Michael Additions can be diastereoselective and/or enantioselective.
The Hemetsberger indole synthesis is a chemical reaction that thermally decomposes a 3-aryl-2-azido-propenoic ester into an indole-2-carboxylic ester.
In statistics, the Durbin–Watson statistic is a test statistic used to detect the presence of autocorrelation at lag 1 in the residuals from a regression analysis. It is named after James Durbin and Geoffrey Watson. The small sample distribution of this ratio was derived by John von Neumann. Durbin and Watson applied this statistic to the residuals from least squares regressions, and developed bounds tests for the null hypothesis that the errors are serially uncorrelated against the alternative that they follow a first order autoregressive process. Note that the distribution of this test statistic does not depend on the estimated regression coefficients and the variance of the errors.
In set theory, the axiom of limitation of size was proposed by John von Neumann in his 1925 axiom system for sets and classes. It formalizes the limitation of size principle, which avoids the paradoxes encountered in earlier formulations of set theory by recognizing that some classes are too big to be sets. Von Neumann realized that the paradoxes are caused by permitting these big classes to be members of a class. A class that is a member of a class is a set; a class that is not a set is a proper class. Every class is a subclass of V, the class of all sets. The axiom of limitation of size says that a class is a set if and only if it is smaller than V—that is, there is no function mapping it onto V. Usually, this axiom is stated in the equivalent form: A class is a proper class if and only if there is a function that maps it onto V.
The Benary reaction is an organic reaction. In 1931 Erich Bénary discovered that β-(N,N-dialkylamino)-vinyl ketones reacted with Grignard reagents in a 1,4-addition to give α,β-unsaturated ketones, α,β-unsaturated aldehydes and α,β-unsaturated esters as well as poly-unsaturated ketones and aldehydes after hydrolysis of the reaction intermediate and elimination of a dialkylated amine.
In organic chemistry, the Claisen–Schmidt condensation is the reaction between an aldehyde or ketone having an α-hydrogen with an aromatic carbonyl compound lacking an α-hydrogen. This reaction is named after two of its pioneering investigators Rainer Ludwig Claisen and J. G. Schmidt, who independently published on this topic in 1880 and 1881. An example is the synthesis of dibenzylideneacetone ( -1,5-diphenylpenta-1,4-dien-3-one).
Etilefrine is a cardiac stimulant used as an antihypotensive. It is a sympathomimetic amine of the 3-hydroxy-phenylethanolamine series used in treating orthostatic hypotension of neurological, cardiovascular, endocrine or metabolic origin. Intravenous infusion of this compound increases cardiac output, stroke volume, venous return and blood pressure in man and experimental animals, suggesting stimulation of both α and β adrenergic receptors. However, in vitro studies indicate that etilefrine has a much higher affinity for β1 (cardiac) than for β2 adrenoreceptors.
U-90042 is a sedative and hypnotic drug used in scientific research. It has similar effects to sedative-hypnotic benzodiazepine drugs, but is structurally distinct and so is classed as a nonbenzodiazepine hypnotic.
In set theory, an ordinal number, or ordinal, is a generalization of ordinal numerals aimed to extend enumeration to infinite sets.
4-Hydroxy-α-methyltryptamine (4-HO-αMT) is a psychedelic drug of the tryptamine class. It is a close structural analogue of α-methyltryptamine (αMT) and produces similar effects to it, but with exacerbated side effects similarly to 5-MeO-αMT. Alexander Shulgin describes 4-HO-αMT briefly in his book TiHKAL:
The 4-hydroxy analogue of αMT has been looked at in human subjects. It is reported to be markedly visual in its effects, with some subjects reporting dizziness and a depressed feeling. There were, however, several toxic signs at doses of 15 to 20 milligrams orally, including abdominal pain, tachycardia, increased blood pressure and, with several people, headache and diarrhea.
The Delaporte distribution is a discrete probability distribution that has received attention in actuarial science. It can be defined using the convolution of a negative binomial distribution with a Poisson distribution. Just as the negative binomial distribution can be viewed as a Poisson distribution where the mean parameter is itself a random variable with a gamma distribution, the Delaporte distribution can be viewed as a compound distribution based on a Poisson distribution, where there are two components to the mean parameter: a fixed component, which has the parameter, and a gamma-distributed variable component, which has the and parameters. The distribution is named for Pierre Delaporte, who analyzed it in relation to automobile accident claim counts in 1959, although it appeared in a different form as early as 1934 in a paper by Rolf von Lüders, where it was called the Formel II distribution.
17α-Epiestriol, or simply 17-epiestriol, also known as 16α-hydroxy-17α-estradiol or estra-1,3,5(10)-triene-3,16α,17α-triol, is a minor and weak endogenous estrogen, and the 17α-epimer of estriol. It is formed from 16α-hydroxyestrone. In contrast to other endogenous estrogens like estradiol, 17α-epiestriol is a selective agonist of the ERβ. It is described as a relatively weak estrogen, which is in accordance with its relatively low affinity for the ERα. 17α-Epiestriol has been found to be approximately 400-fold more potent than estradiol in inhibiting tumor necrosis factor α (TNFα)-induced vascular cell adhesion molecule 1 (VCAM-1) expression in vitro.
20β-Dihydroprogesterone (20β-DHP), also known as 20β-hydroxyprogesterone (20β-OHP), is an endogenous metabolite of progesterone which is formed by 20β-hydroxysteroid dehydrogenase (20β-HSD). It is a progestogen similarly to progesterone, with about 20 to 50% of the progestogenic activity of progesterone. It can be converted by 20β-HSD into progesterone in the uterus. The effects of 20β-HSD on the uterus, mammary glands, and in maintaining pregnancy have been studied. The progestogenic activity of 20β-HSD has also been characterized in women.
16-Methylene-17α-hydroxyprogesterone acetate is a progestin of the 17α-hydroxyprogesterone group which was never marketed. Given orally, it shows about 2.5-fold the progestogenic activity of parenteral progesterone in animal bioassays. It is a parent compound of the following clinically used progestins:
Gestonorone acetate, or gestronol acetate, also known as norhydroxyprogesterone acetate, is a progestin of the 19-norprogesterone and 17α-hydroxyprogesterone groups which was developed in the early 1960s but was never marketed. It is the C17α acetate ester of gestronol (17α-hydroxy-19-norprogesterone).
Belzutifan, sold under the brand name Welireg, is a medication used for the treatment of von Hippel–Lindau disease-associated renal cell carcinoma. It is taken by mouth.
