DAPK3

Last updated
DAPK3
Protein DAPK3 PDB 1yrp.png
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases DAPK3 , DLK, ZIP, ZIPK, death-associated protein kinase 3, death associated protein kinase 3
External IDs OMIM: 603289 MGI: 1203520 HomoloGene: 20353 GeneCards: DAPK3
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001348
NM_001375658

NM_001190473
NM_001190474
NM_007828

RefSeq (protein)

NP_001339
NP_001362587

NP_001177402
NP_001177403
NP_031854

Location (UCSC) Chr 19: 3.96 – 3.97 Mb Chr 10: 81.02 – 81.03 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Death-associated protein kinase 3 is an enzyme that in humans is encoded by the DAPK3 gene. [5] [6]

Contents

Function

Death-associated protein kinase 3 (DAPK3) induces morphological changes in apoptosis when overexpressed in mammalian cells. These results suggest that DAPK3 may play a role in the induction of apoptosis. [6]

Unlike most other mammalian genes, murine (rat and mouse) DAPK3 has undergone accelerated evolution and diverged from the tightly conserved consensus that is maintained from fish to human. [7]

Interactions

DAPK3 has been shown to interact with PAWR [8] and Death associated protein 6. [8]

Related Research Articles

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<span class="mw-page-title-main">MAP3K8</span> Protein-coding gene in the species Homo sapiens

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<span class="mw-page-title-main">MEIS1</span> Protein-coding gene in humans

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<span class="mw-page-title-main">MKNK2</span> Protein-coding gene in the species Homo sapiens

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Transcription factor MafK is a bZip Maf transcription factor protein that in humans is encoded by the MAFK gene.

<span class="mw-page-title-main">DAPK2</span> Protein-coding gene in the species Homo sapiens

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References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000167657 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000034974 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Kawai T, Matsumoto M, Takeda K, Sanjo H, Akira S (Mar 1998). "ZIP kinase, a novel serine/threonine kinase which mediates apoptosis". Molecular and Cellular Biology. 18 (3): 1642–51. doi:10.1128/mcb.18.3.1642. PMC   108879 . PMID   9488481.
  6. 1 2 "Entrez Gene: DAPK3 death-associated protein kinase 3".
  7. Shoval Y, Pietrokovski S, Kimchi A (Oct 2007). "ZIPK: a unique case of murine-specific divergence of a conserved vertebrate gene". PLOS Genetics. 3 (10): 1884–93. doi: 10.1371/journal.pgen.0030180 . PMC   2041995 . PMID   17953487.
  8. 1 2 Kawai T, Akira S, Reed JC (Sep 2003). "ZIP kinase triggers apoptosis from nuclear PML oncogenic domains". Molecular and Cellular Biology. 23 (17): 6174–86. doi:10.1128/MCB.23.17.6174-6186.2003. PMC   180930 . PMID   12917339.

Further reading