A basic helix–loop–helix (bHLH) is a protein structural motif that characterizes one of the largest families of dimerizing transcription factors. The word "basic" does not refer to complexity but to the chemistry of the motif because transcription factors in general contain basic amino acid residues in order to facilitate DNA binding.
Myc is a family of regulator genes and proto-oncogenes that code for transcription factors. The Myc family consists of three related human genes: c-myc (MYC), l-myc (MYCL), and n-myc (MYCN). c-myc was the first gene to be discovered in this family, due to homology with the viral gene v-myc.
N-myc proto-oncogene protein also known as N-Myc or basic helix-loop-helix protein 37 (bHLHe37), is a protein that in humans is encoded by the MYCN gene.
Transcription factor 3, also known as TCF3, is a protein that in humans is encoded by the TCF3 gene. TCF3 has been shown to directly enhance Hes1 expression.
Paired amphipathic helix protein Sin3a is a protein that in humans is encoded by the SIN3A gene.
DNA-binding protein inhibitor ID-2 is a protein that in humans is encoded by the ID2 gene.
MAX is a gene that in humans encodes the MAX transcription factor.
DNA-binding protein inhibitor ID-3 is a protein that in humans is encoded by the ID3 gene.
MAX-interacting protein 1 is a protein that in humans is encoded by the MXI1 gene.
Transcription factor HES1 is a protein that is encoded by the Hes1 gene, and is the mammalian homolog of the hairy gene in Drosophila. HES1 is one of the seven members of the Hes gene family (HES1-7). Hes genes code nuclear proteins that suppress transcription.
MHC class II regulatory factor RFX1 is a protein that, in humans, is encoded by the RFX1 gene located on the short arm of chromosome 19.
L-myc-1 proto-oncogene protein is a protein that in humans is encoded by the MYCL1 gene.
MAD protein is a protein that in humans is encoded by the MXD1 gene.
ETS domain-containing transcription factor ERF is a protein that in humans is encoded by the ERF gene.
Max-like protein X is a protein that in humans is encoded by the MLX gene.
Max-interacting transcriptional repressor MAD4 is a protein that in humans is encoded by the MXD4 gene.
MNT is a Max-binding protein that is encoded by the MNT gene
Transcription factor AP-4 , also known as TFAP4, is a protein which in humans is encoded by the TFAP4 gene.
"Basic helix-loop-helix family, member e41", or BHLHE41, is a gene that encodes a basic helix-loop-helix transcription factor repressor protein in various tissues of both humans and mice. It is also known as DEC2, hDEC2, and SHARP1, and was previously known as "basic helix-loop-helix domain containing, class B, 3", or BHLHB3. BHLHE41 is known for its role in the circadian molecular mechanisms that influence sleep quantity as well as its role in immune function and the maturation of T helper type 2 cell lineages associated with humoral immunity.
Homeobox protein Nkx-6.1 is a protein that in humans is encoded by the NKX6-1 gene.
