POU domain, class 4, transcription factor 2 is a protein that in humans is encoded by the POU4F2 gene. [5] [6]
POU4F2 is a member of the POU-domain family of transcription factors. POU-domain proteins have been observed to play important roles in control of cell identity in several systems. A class IV POU-domain protein, POU4F2 is found in human retina exclusively within a subpopulation of ganglion cells where it may play a role in determining or maintaining the identities of a small subset of visual system neurons.[supplied by OMIM] [6]
POU4F2 has been shown to interact with Estrogen receptor alpha. [7]
Estrogen receptor alpha (ERα), also known as NR3A1, is one of two main types of estrogen receptor, a nuclear receptor that is activated by the sex hormone estrogen. In humans, ERα is encoded by the gene ESR1.
POU domain, class 1, transcription factor 1 , also known as POU1F1, is a transcription factor for growth hormone.
Oct-2 also known as POU domain, class 2, transcription factor 2 is a protein that in humans is encoded by the POU2F2 gene.
BRN-3 is a group of related transcription factors in the POU family. They are also known as class 4 POU domain homeobox proteins.
Heat shock factor 1 (HSF1) is a protein that in humans is encoded by the HSF1 gene. HSF1 is highly conserved in eukaryotes and is the primary mediator of transcriptional responses to proteotoxic stress with important roles in non-stress regulation such as development and metabolism.
POU domain, class 2, transcription factor 1 is a protein that in humans is encoded by the POU2F1 gene.
RNA-binding protein EWS is a protein that in humans is encoded by the EWSR1 gene on human chromosome 22, specifically 22q12.2. It is one of 3 proteins in the FET protein family. The q22.2 region of chromosome 22 encodes the N-terminal transactivation domain of the EWS protein and that region may become joined to one of several other chromosomes which encode various transcription factors, see and the FET protein family. The expression of a chimeric protein with the EWS transactivation domain fused to the DNA binding region of a transcription factor generates a powerful oncogenic protein causing Ewing sarcoma and other members of the Ewing family of tumors. These translocations can occur due to chromoplexy, a burst of complex chromosomal rearrangements seen in cancer cells. The normal EWS gene encodes an RNA binding protein closely related to FUS (gene) and TAF15, all of which have been associated to amyotrophic lateral sclerosis.
POU domain, class 3, transcription factor 2 is a protein that in humans is encoded by the POU3F2 gene.
POU domain, class 4, transcription factor 1 (POU4F1) also known as brain-specific homeobox/POU domain protein 3A (BRN3A), homeobox/POU domain protein RDC-1 or Oct-T1 is a protein that in humans is encoded by the POU4F1 gene.
Dachshund homolog 1, also known as DACH1, is a protein which in humans is encoded by the DACH1 gene. DACH1 has been shown to interact with Ubc9, Smad4, and NCoR.
Transcription factor Sp4 is a protein that in humans is encoded by the SP4 gene.
Protein atonal homolog 1 is a protein that in humans is encoded by the ATOH1 gene.
POU domain, class 3, transcription factor 1 is a protein that in humans is encoded by the POU3F1 gene.
Early growth response protein 3 is a protein in humans, encoded by the EGR3 gene.
Homeobox protein Hox-C10 is a protein that in humans is encoded by the HOXC10 gene.
POU domain, class 2, transcription factor 3 is a protein that in humans is encoded by the POU2F3 gene.
POU domain, class 3, transcription factor 4 is a protein that in humans is encoded by the POU3F4 gene found on the X chromosome.
GTP-binding protein Rit2 is a protein that in humans is encoded by the RIT2 gene.
POU domain, class 4, transcription factor 3 is a protein that in humans is encoded by the POU4F3 gene. It's a member of BRN-3 group, also known as POU family class 4.
Transcription factor AP-2 gamma also known as AP2-gamma is a protein that in humans is encoded by the TFAP2C gene. AP2-gamma is a member of the activating protein 2 family of transcription factors.
This article incorporates text from the United States National Library of Medicine, which is in the public domain.